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Hashizume, H. et al.

Effects of phenylalaninol on centrally induced gastric acid secretion.

The effects of phenylalaninol (D-isomer) on gastric acid secretion and gastric ulcer were studied in rats. The compound reduced the gastric acid secretion stimulated by intracisternal thyrotropin releasing hormone and intravenous 2-deoxy-D-glucose, but not that stimulated by subcutaneous carbachol or histamine. Phenylalaninol prevented stress- and indomethacin-induced gastric ulcers. We conclude that phenylalaninol inhibits ulcer formation mainly by central inhibition of gastric acid secretion.[1]

References

Effects of phenylalaninol on centrally induced gastric acid secretion. Hashizume, H., Miyamae, T., Morikawa, T., Hagiwara, M. Chem. Pharm. Bull. (1992) [Pubmed]

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