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Chemical Compound Review:

Phenylalaninol 2-amino-3-phenyl-propan-1-ol

Synonyms: SureCN2521, CHEMBL21676, AG-E-10483, ACMC-209dls, ACMC-209hp6, ...

Lynam, C. et al., Tachikawa, E. et al., Babu, E. et al., Hashizume, H. et al., Leclerc, G. et al., et al.

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Disease relevance of NSC 20899

The effects of phenylalaninol (D-isomer) on gastric acid secretion and gastric ulcer were studied in rats [1].

High impact information on NSC 20899

In contrast, l-leucinol, l-valinol, and l-phenylalaninol, which have a net positive charge induced inward currents under voltage clamp, suggesting these compounds are transported by LAT3 [2].
We examined the effect of trichosporin-B-III, an alpha-aminoisobutyric acid-containing antibiotic peptide consisting of 19 amino acid residues and a phenylalaninol, on catecholamine secretion from cultured bovine adrenal chromaffin cells [3].
This molecule can discriminate between the enantiomers of phenylalaninol through the quenching of the fluorescence emission in methanol in contrast to an (S)-dinaphthylprolinol calix[4]arene derivative, which can discriminate between the enantiomers of phenylglycinol, but not phenylalaninol [4].
Longibrachins are 20-residue peptaibols with a C-terminal phenylalaninol and either neutral (LGA; Gln18) or acidic (LGB; Glu18) character [5].
Effects of phenylalaninol on centrally induced gastric acid secretion [1].

Biological context of NSC 20899

Inhibition of intestinal absorption of phenylalanine by phenylalaninol [6].
Alamethicin biosynthesis: acetylation of the amino terminus and attachment of phenylalaninol [7].

References

Effects of phenylalaninol on centrally induced gastric acid secretion. Hashizume, H., Miyamae, T., Morikawa, T., Hagiwara, M. Chem. Pharm. Bull. (1992) [Pubmed]
Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. Babu, E., Kanai, Y., Chairoungdua, A., Kim, d.o. .K., Iribe, Y., Tangtrongsup, S., Jutabha, P., Li, Y., Ahmed, N., Sakamoto, S., Anzai, N., Nagamori, S., Endou, H. J. Biol. Chem. (2003) [Pubmed]
Trichosporin-B-III, an alpha-aminoisobutyric acid-containing peptide, causes Ca(2+)-dependent catecholamine secretion from adrenal medullary chromaffin cells. Tachikawa, E., Takahashi, S., Furumachi, K., Kashimoto, T., Iida, A., Nagaoka, Y., Fujita, T., Takaishi, Y. Mol. Pharmacol. (1991) [Pubmed]
Tuning and enhancing enantioselective quenching of calixarene hosts by chiral guest amines. Lynam, C., Jennings, K., Nolan, K., Kane, P., McKervey, M.A., Diamond, D. Anal. Chem. (2002) [Pubmed]
Sequences and antimycoplasmic properties of longibrachins LGB II and LGB III, two novel 20-residue peptaibols from Trichoderma longibrachiatum. Leclerc, G., Goulard, C., Prigent, Y., Bodo, B., Wróblewski, H., Rebuffat, S. J. Nat. Prod. (2001) [Pubmed]
Inhibition of intestinal absorption of phenylalanine by phenylalaninol. Shimomura, K., Fukushima, T., Danno, T., Matsumoto, K., Miyoshi, M. J. Biochem. (1975) [Pubmed]
Alamethicin biosynthesis: acetylation of the amino terminus and attachment of phenylalaninol. Mohr, H., Kleinkauf, H. Biochim. Biophys. Acta (1978) [Pubmed]

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