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Corcione, A. et al.

Corcione, Arduino, Ferretti, Raffaghello, Roncella, Rossi, Fedeli, Ottonello, Trentin, Dallegri, Semenzato, Pistoia,

CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells.

PURPOSE: Few data are available in the literature on chemokine receptor expression and migratory capability of mantle cell lymphoma (MCL) B cells. Information on these issues may allow us to identify novel mechanisms of chemokine-driven tumor cell migration. EXPERIMENTAL DESIGN: The research was designed to investigate: (a) expression of CCR1 to CCR7 and CXCR1 to CXCR5 chemokine receptors; and (b) chemotaxis to the respective ligands in MCL B cells and in their normal counterparts, i.e., CD5+ B cells. RESULTS: Malignant B cells from MCL patients and normal counterparts displayed similar chemokine receptor profiles. MCL B cells were induced to migrate by CXCL12 and CCL19, whereas normal CD5+ B cells migrated to the former, but not the latter chemokine. Overnight culture of MCL B cells and their normal counterparts with CXCL12 cross-sensitized other chemokine receptors to their ligands in some tumor samples but not in CD5+ B cells. CONCLUSIONS: CCR7 and CXCR4 ligands may play a key role in tumor cell migration and spreading in vivo. CXCL12 may additionally contribute by sensitizing MCL B cells to respond to the ligands of other chemokine receptors.[1]

References

CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells. Corcione, A., Arduino, N., Ferretti, E., Raffaghello, L., Roncella, S., Rossi, D., Fedeli, F., Ottonello, L., Trentin, L., Dallegri, F., Semenzato, G., Pistoia, V. Clin. Cancer Res. (2004) [Pubmed]

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