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Gene Review

CXCR5  -  chemokine (C-X-C motif) receptor 5

Homo sapiens

Synonyms: BLR1, Burkitt lymphoma receptor 1, C-X-C chemokine receptor type 5, CD185, CXC-R5, ...
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Disease relevance of BLR1


High impact information on BLR1


Chemical compound and disease context of BLR1

  • Interphotoreceptor retinoid-binding protein and retinal arrestin (S-antigen) are targets of autoantibodies in human uveitis and are chemotactic for CXC chemokine receptor 5 (CXCR5)- and/or CXCR3-expressing iDC [6].

Biological context of BLR1


Anatomical context of BLR1


Associations of BLR1 with chemical compounds

  • Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells [10].
  • METHODS: Serial immunohistochemical staining for CXCL13, CXCR5, and CD20 was carried out in protocol biopsies of 23 patients obtained between day 4 and day 9 after renal transplantation [8].
  • Lou/C rats were immunized with BLR1 transfected, tagged 293 cells and after fusion of spleen cells with X63 Ag8.653 myeloma cells supernatants were tested for BLR1 specific antibodies by comparing the binding to BLR1 transfected 293 cells and to untransfected control cells immobilised on poly-L-lysine coated microtiter plates [11].
  • The BLR-1 protein has all the characteristics of a blue-light photoreceptor, whereas the structure of the deduced BLR-2 protein suggests that it interacts with BLR-1 through PAS domains to form a complex [12].
  • Retinoic acid also induced a higher percentage of functionally differentiated blr1 transfectants as assessed by nitroblue tetrazolium reduction [10].

Regulatory relationships of BLR1

  • The fact that MDR15 and BLR1 are expressed on leucocytes and show marked sequence similarity to chemokine receptors suggests the existence of as yet unidentified chemokines [9].
  • CCR7 transcripts were minimally expressed in ex vivo and proliferating WC1(+)gammadelta T cells and CXCR5 expression was negligible [13].

Other interactions of BLR1

  • BCA-1 was chemically synthesized and tested for activity on murine pre-B cells 300-19 transfected with BLR1 and on human blood B lymphocytes [1].
  • T cells expressing BLR1 were positive for CD45R0, were negative for interleukin-2 receptors, show high levels of CD44, and show low levels of L-selectin [7].
  • MDR15 and BLR1 have high structural similarity to receptors for human IL-8 (about 40% amino acid identity) and other chemokines [9].
  • These studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5 [14].
  • None of the NK cell subsets expressed CXCR2, CXCR5, or CCR5 [15].

Analytical, diagnostic and therapeutic context of BLR1


  1. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. Legler, D.F., Loetscher, M., Roos, R.S., Clark-Lewis, I., Baggiolini, M., Moser, B. J. Exp. Med. (1998) [Pubmed]
  2. A CXC chemokine receptor, CXCR5/BLR1, is a novel and specific coreceptor for human immunodeficiency virus type 2. Kanbe, K., Shimizu, N., Soda, Y., Takagishi, K., Hoshino, H. Virology (1999) [Pubmed]
  3. Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia. Qiuping, Z., Jie, X., Youxin, J., Qun, W., Wei, J., Chun, L., Jin, W., Yan, L., Chunsong, H., Mingzhen, Y., Qingping, G., Qun, L., Kejian, Z., Zhimin, S., Junyan, L., Jinquan, T. Oncogene (2005) [Pubmed]
  4. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Gunn, M.D., Ngo, V.N., Ansel, K.M., Ekland, E.H., Cyster, J.G., Williams, L.T. Nature (1998) [Pubmed]
  5. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. Schaerli, P., Willimann, K., Lang, A.B., Lipp, M., Loetscher, P., Moser, B. J. Exp. Med. (2000) [Pubmed]
  6. Autoantigens act as tissue-specific chemoattractants. Oppenheim, J.J., Dong, H.F., Plotz, P., Caspi, R.R., Dykstra, M., Pierce, S., Martin, R., Carlos, C., Finn, O., Koul, O., Howard, O.M. J. Leukoc. Biol. (2005) [Pubmed]
  7. Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Förster, R., Emrich, T., Kremmer, E., Lipp, M. Blood (1994) [Pubmed]
  8. BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection. Steinmetz, O.M., Panzer, U., Kneissler, U., Harendza, S., Lipp, M., Helmchen, U., Stahl, R.A. Kidney Int. (2005) [Pubmed]
  9. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation. Barella, L., Loetscher, M., Tobler, A., Baggiolini, M., Moser, B. Biochem. J. (1995) [Pubmed]
  10. Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells. Battle, T.E., Yen, A. Exp. Biol. Med. (Maywood) (2002) [Pubmed]
  11. A general method for screening mAbs specific for G-protein coupled receptors as exemplified by using epitope tagged BLR1-transfected 293 cells and solid-phase cell ELISA. Förster, R., Emrich, T., Voss, C., Lipp, M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  12. BLR-1 and BLR-2, key regulatory elements of photoconidiation and mycelial growth in Trichoderma atroviride. Casas-Flores, S., Rios-Momberg, M., Bibbins, M., Ponce-Noyola, P., Herrera-Estrella, A. Microbiology (Reading, Engl.) (2004) [Pubmed]
  13. Molecular cloning of bovine chemokine receptors and expression by WC1+ gammadelta T cells. Blumerman, S.L., Wang, F., Herzig, C.T., Baldwin, C.L. Dev. Comp. Immunol. (2007) [Pubmed]
  14. Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. Howard, O.M., Dong, H.F., Su, S.B., Caspi, R.R., Chen, X., Plotz, P., Oppenheim, J.J. Blood (2005) [Pubmed]
  15. Expression and regulation of chemokine receptors in human natural killer cells. Inngjerdingen, M., Damaj, B., Maghazachi, A.A. Blood (2001) [Pubmed]
  16. Cutting edge: induction of follicular homing precedes effector Th cell development. Schaerli, P., Loetscher, P., Moser, B. J. Immunol. (2001) [Pubmed]
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