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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population.

Very frail older people constitute an increasing proportion of ageing populations and often have vitamin D deficiency. Falls are frequent in this population and have usually been associated with vitamin D deficiency. In this prospective study we measured serum 25-hydroxyvitamin D (25OHD), serum PTH, and falls in 637 ambulatory subjects living in institutional aged care facilities (intermediate-care hostels or nursing homes). The study sample comprised 121 men (mean age, 82.1 yr) and 516 women (mean age, 86.7 yr). Two hundred and seventy-four subjects fell one or more times over a mean duration of follow-up of 10.2 months. Vitamin D deficiency, defined as a serum 25OHD level below 39 nmol/liter was present in 73.6%. Baseline serum 25OHD and PTH were significantly associated with falls in univariate analyses. In multivariate analyses that also corrected for balance and health status, PTH remained a significant predictor of falls independent of 25OHD. Serum PTH is a predictor of time to first fall in the frail elderly independent of vitamin D status and measures of general health.[1]

References

  1. Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. Sambrook, P.N., Chen, J.S., March, L.M., Cameron, I.D., Cumming, R.G., Lord, S.R., Zochling, J., Sitoh, Y.Y., Lau, T.C., Schwarz, J., Seibel, M.J. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
 
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