Disease relevance of Frail Elderly

• Vinorelbine and prednisone in frail elderly patients with intermediate-high grade non-Hodgkin's lymphomas [1].
• These assays should prove useful for predicting the hormone responsiveness of breast cancer from tumour cells obtained by FNA at diagnosis and could be particularly useful in the management of elderly/frail patients who receive primary tamoxifen, or in other patients for whom tumour tissue for standard biochemical measurements is not available [2].
• CONCLUSIONS: Nandrolone can be given safely to frail elderly subjects with hip fractures but is likely to be of minimal benefit at the doses we employed [3].
• Paracetamol clearance expressed in terms of body weight was significantly lower in the fit elderly than in the fit young subjects, and was lowest in the frail elderly subjects (p less than 0.01) [4].
• Seventy frail elderly patients attending a day hospital were studied to investigate the incidence of postural hypotension in control patients on no diuretic treatment (n = 30), patients on loop diuretics (frusemide) for mild cardiac failure (n = 20) and patients on thiazide diuretics for mild cardiac failure (n = 20) [5].

High impact information on Frail Elderly

• Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial [6].
• Both TNF-alpha mRNA and protein levels were elevated in skeletal muscle from frail elderly (81+/-1 year) as compared to healthy young (23+/-1 year) men and women [7].
• In conclusion, we found that an intervention with 10 microg of vitamin D3 alone produced no fracture-preventing effect in a nursing home population of frail elderly people [8].
• Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group [9].
• Serum PTH is a predictor of time to first fall in the frail elderly independent of vitamin D status and measures of general health [10].

Chemical compound and disease context of Frail Elderly

• The more frail elderly patients with coexistent disease, often taking other treatments, are more at risk from digoxin toxicity due to inappropriate dosing, noncompliance, or increased sensitivity to digoxin resulting from pharmacokinetic or pharmacodynamic interactions [11].
• PH may be a useful anticonvulsive agent in frail elderly patients, who are at risk for the development of pressure ulcers [12].

Biological context of Frail Elderly

• BACKGROUND AND PURPOSE: Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke [13].

Associations of Frail Elderly with chemical compounds

• Estrogen for bone health in frail elderly women [14].
• Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning [15].
• The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women [16].
• A considerably higher interindividual variability in the disposition of phenazone and theophylline was observed in the frail elderly women [16].
• CONCLUSION: In this frail elderly population, venlafaxine was less well tolerated and, possibly, less safe than sertraline without evidence for an increase in efficacy [17].

Gene context of Frail Elderly

• Peripheral blood mononuclear cells (PBMC) of frail elderly nursing home residents had significantly higher PHA-induced interleukin-10 (IL-10) production compared to PBMC's from young control subjects [18].
• CONCLUSIONS: These results suggest that, compared with non-frail controls, frail older adults have both decreased LPS-induced proliferation and increased IL-6 production by PBMC [19].
• More research is needed before it will be known whether the benefits of administering GH to the frail elderly will outweigh the disadvantages [20].
• The two classes of GH secretagogs--GH-releasing hormone (GHRH) and the GH-releasing peptides and their analogs (GHRP's)--retain their ability to endogenous GH secretion in healthy and frail elderly subjects [21].
• These results confirm our presumption that a low CD4 lymphocyte count and a low CD4/CD8 ratio could prevail among elderly frail patients with dysphagia [22].

Analytical, diagnostic and therapeutic context of Frail Elderly

• Therapeutic drug monitoring of theophylline in frail elderly patients: oral compared with nasogastric tube administration [23].
• Is oral oseltamivir safe and effective for the prevention of influenza and its complications in frail elderly long-term care residents who have received influenza vaccine [24]?
• Clinicians at the SCO Health Service were concerned that frail elderly patients who had shorter lengths of stay in rehabilitation would not be able to maintain their gains following discharge [25].

References