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MeSH Review

Frail Elderly

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Disease relevance of Frail Elderly

  • Vinorelbine and prednisone in frail elderly patients with intermediate-high grade non-Hodgkin's lymphomas [1].
  • These assays should prove useful for predicting the hormone responsiveness of breast cancer from tumour cells obtained by FNA at diagnosis and could be particularly useful in the management of elderly/frail patients who receive primary tamoxifen, or in other patients for whom tumour tissue for standard biochemical measurements is not available [2].
  • CONCLUSIONS: Nandrolone can be given safely to frail elderly subjects with hip fractures but is likely to be of minimal benefit at the doses we employed [3].
  • Paracetamol clearance expressed in terms of body weight was significantly lower in the fit elderly than in the fit young subjects, and was lowest in the frail elderly subjects (p less than 0.01) [4].
  • Seventy frail elderly patients attending a day hospital were studied to investigate the incidence of postural hypotension in control patients on no diuretic treatment (n = 30), patients on loop diuretics (frusemide) for mild cardiac failure (n = 20) and patients on thiazide diuretics for mild cardiac failure (n = 20) [5].

High impact information on Frail Elderly


Chemical compound and disease context of Frail Elderly

  • The more frail elderly patients with coexistent disease, often taking other treatments, are more at risk from digoxin toxicity due to inappropriate dosing, noncompliance, or increased sensitivity to digoxin resulting from pharmacokinetic or pharmacodynamic interactions [11].
  • PH may be a useful anticonvulsive agent in frail elderly patients, who are at risk for the development of pressure ulcers [12].

Biological context of Frail Elderly

  • BACKGROUND AND PURPOSE: Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke [13].

Associations of Frail Elderly with chemical compounds


Gene context of Frail Elderly

  • Peripheral blood mononuclear cells (PBMC) of frail elderly nursing home residents had significantly higher PHA-induced interleukin-10 (IL-10) production compared to PBMC's from young control subjects [18].
  • CONCLUSIONS: These results suggest that, compared with non-frail controls, frail older adults have both decreased LPS-induced proliferation and increased IL-6 production by PBMC [19].
  • More research is needed before it will be known whether the benefits of administering GH to the frail elderly will outweigh the disadvantages [20].
  • The two classes of GH secretagogs--GH-releasing hormone (GHRH) and the GH-releasing peptides and their analogs (GHRP's)--retain their ability to endogenous GH secretion in healthy and frail elderly subjects [21].
  • These results confirm our presumption that a low CD4 lymphocyte count and a low CD4/CD8 ratio could prevail among elderly frail patients with dysphagia [22].

Analytical, diagnostic and therapeutic context of Frail Elderly


  1. Vinorelbine and prednisone in frail elderly patients with intermediate-high grade non-Hodgkin's lymphomas. Tirelli, U., Balzarotti, M., Uziel, L., Ferreri, A.J., Santoro, A., Spina, M. Ann. Oncol. (2006) [Pubmed]
  2. Determination of oestrogen responsiveness of breast cancer by competitive reverse transcription-polymerase chain reaction. Carr, M., May, F.E., Lennard, T.W., Westley, B.R. Br. J. Cancer (1995) [Pubmed]
  3. A pilot study of anabolic steroids in elderly patients with hip fractures. Sloan, J.P., Wing, P., Dian, L., Meneilly, G.S. Journal of the American Geriatrics Society. (1992) [Pubmed]
  4. The association of age and frailty with paracetamol conjugation in man. Wynne, H.A., Cope, L.H., Herd, B., Rawlins, M.D., James, O.F., Woodhouse, K.W. Age and ageing. (1990) [Pubmed]
  5. Loop diuretics cause less postural hypotension than thiazide diuretics in the frail elderly. Heseltine, D., Bramble, M.G. Current medical research and opinion. (1988) [Pubmed]
  6. Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial. Villareal, D.T., Binder, E.F., Williams, D.B., Schechtman, K.B., Yarasheski, K.E., Kohrt, W.M. JAMA (2001) [Pubmed]
  7. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. Greiwe, J.S., Cheng, B., Rubin, D.C., Yarasheski, K.E., Semenkovich, C.F. FASEB J. (2001) [Pubmed]
  8. Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomized controlled trial. Meyer, H.E., Smedshaug, G.B., Kvaavik, E., Falch, J.A., Tverdal, A., Pedersen, J.I. J. Bone Miner. Res. (2002) [Pubmed]
  9. Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group. Murphy, M.G., Bach, M.A., Plotkin, D., Bolognese, J., Ng, J., Krupa, D., Cerchio, K., Gertz, B.J. J. Bone Miner. Res. (1999) [Pubmed]
  10. Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. Sambrook, P.N., Chen, J.S., March, L.M., Cameron, I.D., Cumming, R.G., Lord, S.R., Zochling, J., Sitoh, Y.Y., Lau, T.C., Schwarz, J., Seibel, M.J. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  11. Digoxin toxicity in the aged. Characterising and avoiding the problem. Passmore, A.P., Johnston, G.D. Drugs & aging. (1991) [Pubmed]
  12. Antiepileptic drug use and the occurrence of pressure ulcers among bedridden institutionalized elderly patients: a retrospective chart review. Arinzon, Z., Zeilig, G., Berner, Y.N., Adunsky, A. The American journal of geriatric pharmacotherapy. (2005) [Pubmed]
  13. Postprandial and orthostatic cardiovascular changes after acute stroke. Robinson, T.G., Potter, J.F. Stroke (1995) [Pubmed]
  14. Estrogen for bone health in frail elderly women. Reed, S.B., Bellantoni, M.F. JAMA (2001) [Pubmed]
  15. Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning. de Jong, N., Chin A Paw, M.J., de Groot, L.C., Rutten, R.A., Swinkels, D.W., Kok, F.J., van Staveren, W.A. Am. J. Clin. Nutr. (2001) [Pubmed]
  16. The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women. Groen, K., Horan, M.A., Roberts, N.A., Gulati, R.S., Miljkovic, B., Jansen, E.J., Paramsothy, V., Breimer, D.D., van Bezooijen, C.F. Clinical pharmacokinetics. (1993) [Pubmed]
  17. Probing the safety of medications in the frail elderly: evidence from a randomized clinical trial of sertraline and venlafaxine in depressed nursing home residents. Oslin, D.W., Ten Have, T.R., Streim, J.E., Datto, C.J., Weintraub, D., DiFilippo, S., Katz, I.R. The Journal of clinical psychiatry. (2003) [Pubmed]
  18. Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents. Castle, S., Uyemura, K., Wong, W., Modlin, R., Effros, R. Mech. Ageing Dev. (1997) [Pubmed]
  19. Decreased cell proliferation and altered cytokine production in frail older adults. Leng, S.X., Yang, H., Walston, J.D. Aging clinical and experimental research. (2004) [Pubmed]
  20. Frailty in the elderly: contributions of sarcopenia and visceral protein depletion. Vanitallie, T.B. Metab. Clin. Exp. (2003) [Pubmed]
  21. Potential applications of GH secretagogs in the evaluation and treatment of the age-related decline in growth hormone secretion. Merriam, G.R., Buchner, D.M., Prinz, P.N., Schwartz, R.S., Vitiello, M.V. Endocrine (1997) [Pubmed]
  22. CD4 lymphocyte count and CD4/CD8 ratio in elderly long-term care patients with oropharyngeal dysphagia: comparison between oral and tube enteral feeding. Leibovitz, A., Sharon-Guidetti, A., Segal, R., Blavat, L., Peller, S., Habot, B. Dysphagia. (2004) [Pubmed]
  23. Therapeutic drug monitoring of theophylline in frail elderly patients: oral compared with nasogastric tube administration. Berkovitch, M., Dafni, O., Leiboviz, A., Mayan, H., Habut, B., Segal, R. Therapeutic drug monitoring. (2002) [Pubmed]
  24. Is oral oseltamivir safe and effective for the prevention of influenza and its complications in frail elderly long-term care residents who have received influenza vaccine? Sturpe, D., Seaton, T.L. The Journal of family practice. (2002) [Pubmed]
  25. The impact of reducing in-patient stay on long-term geriatric rehabilitation outcome. Knoefel, F.D. Healthcare management forum / Canadian College of Health Service Executives = Forum gestion des soins de santé / Collège canadien des directeurs de services de santé. (2005) [Pubmed]
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