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MeSH Review

Nursing Homes

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Disease relevance of Nursing Homes


Psychiatry related information on Nursing Homes


High impact information on Nursing Homes

  • CONTEXT: Alzheimer disease special care units (SCUs) in nursing homes are increasingly prevalent, but little is known about their effects on residents' outcomes [11].
  • Using a series of logistic analyses, the shift in location of death from hospitals to nursing homes was found to be more pronounced after implementation of the PPS [12].
  • Of 2135 elderly residents of nursing homes in Arkansas (mean age, 79.4 years) who have been treated with isoniazid for prevention of tuberculosis, data from 1935 were suitable for analysis [13].
  • In a series of 429 white subjects from two Jewish nursing homes, an association of APOE4 with AD was found only in patients homozygous for the G,C allele of DLST [14].
  • In this period, the proportion of MRSA cases acquired in our institution decreased from 50.0% in 1999 to 6.1% in 2002 (P<.001), whereas the proportion of MRSA cases transferred from other hospitals (P<.001) and nursing homes (P = .03) increased [15].

Chemical compound and disease context of Nursing Homes


Biological context of Nursing Homes


Anatomical context of Nursing Homes


Associations of Nursing Homes with chemical compounds

  • The predominance of methicillin-resistant S. aureus infections in these large hospitals may be due to the large numbers of patients at high risk of infection and to the interhospital spread of the organism by the transfer of infected patients and house staff from similar hospitals or from nursing homes [26].
  • Amantadine-resistant influenza A in nursing homes. Identification of a resistant virus prior to drug use [27].
  • Among 64637 patients with CHF admitted to all nursing homes in 5 states between 1992 and 1995, we identified 19492 patients taking either an ACE inhibitor (n = 4911) or digoxin (n = 14890) [28].
  • CONCLUSIONS: Results of this work suggest that longterm use of haloperidol, thioridazine, and lorazepam in nursing homes to manage agitation should be closely monitored for their efficacy [29].
  • Mean serum 25-hydroxyvitamin D (calcidiol) was 10.8 +/- 4.4 nmol/L (27 +/- 11 ng/mL) in women living in nursing homes and was similar to that of free-living young (11.3 +/- 4.2 nmol/L, or 28 +/- 10 ng/mL) and elderly (11.5 +/- 3.2 nmol/L, or 29 +/- 8 ng/mL) women [3].

Gene context of Nursing Homes

  • A cohort of elderly Norwegians dying in nursing homes in the Oslo region have been genotyped for the Apolipoprotein E (ApoE) gene [30].
  • There was movement of some respondents into nursing homes by the Wave 2 interview [31].
  • RESULTS: The prevalence of MRSA colonization was significantly higher in the VA NHCU than in the community nursing homes (mean +/- SD 30.3% +/- 11% versus 9.9% +/- 4%) [32].
  • SETTING: The On-line Survey Certification of Automated Records (OSCAR) was used to obtain facility characteristics from 1,057 licensed nursing homes in six states from 1995 to 1996 [33].
  • A point-prevalence survey performed among residents of eight nursing homes in Melbourne, Australia, found a rate of fecal VRE colonization of 3.1% (9/292; 95% confidence interval, 1.1-5.1), all vanB Enterococcusfaecium [34].

Analytical, diagnostic and therapeutic context of Nursing Homes

  • Proportions of hip fracture patients dying during hospitalization and those discharged to nursing homes, respectively, were: White men (10.5%; 49%); Black men (9.3%; 32%); White women (5.0%; 54%); and Black women (8.2%; 30%) [35].
  • CONCLUSIONS: The implementation of the PPS in nursing homes has been associated with a decrease in the amount of rehabilitation services, targeted at those predicted to receive higher amounts and an increased frequency of providing services targeted at those predicted to be less likely to receive them [36].
  • SETTING: Multicenter study in 60 hostels (assisted living facilities) and 89 nursing homes across Australia. PARTICIPANTS: Six hundred twenty-five residents (mean age 83.4) with serum 25-hydroxyvitamin D levels between 25 and 90 nmol/L [37].
  • BACKGROUND: Large outbreaks of influenza A and B may occur in nursing homes despite high resident vaccination rates, even when the vaccine strain is matched to the circulating strain [38].
  • METHODS: A retrospective case note audit of the admission characteristics of residents in nursing homes registered with the Manchester Health Authority who died within a 12 month period and a group of current residents matched by age, sex and length of stay [39].


  1. Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes. Wiener, J., Quinn, J.P., Bradford, P.A., Goering, R.V., Nathan, C., Bush, K., Weinstein, R.A. JAMA (1999) [Pubmed]
  2. Methicillin-resistant Staphylococcus aureus in nursing homes. Cherubin, C.E., Antar, S., Jurkovic, J. Ann. Intern. Med. (1992) [Pubmed]
  3. Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes. Kinyamu, H.K., Gallagher, J.C., Balhorn, K.E., Petranick, K.M., Rafferty, K.A. Am. J. Clin. Nutr. (1997) [Pubmed]
  4. Detection of amantadine-resistant influenza A virus strains in nursing homes by PCR-restriction fragment length polymorphism analysis with nasopharyngeal swabs. Saito, R., Oshitani, H., Masuda, H., Suzuki, H. J. Clin. Microbiol. (2002) [Pubmed]
  5. Scabies in nursing homes: an eradication program with permethrin 5% cream. Yonkosky, D., Ladia, L., Gackenheimer, L., Schultz, M.W. J. Am. Acad. Dermatol. (1990) [Pubmed]
  6. Depression and mortality in nursing homes. Rovner, B.W., German, P.S., Brant, L.J., Clark, R., Burton, L., Folstein, M.F. JAMA (1991) [Pubmed]
  7. The effect of integrated emotion-oriented care versus usual care on elderly persons with dementia in the nursing home and on nursing assistants: a randomized clinical trial. Finnema, E., Dröes, R.M., Ettema, T., Ooms, M., Adèr, H., Ribbe, M., van Tilburg, W. International journal of geriatric psychiatry. (2005) [Pubmed]
  8. Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study. Winblad, B., Kilander, L., Eriksson, S., Minthon, L., Båtsman, S., Wetterholm, A.L., Jansson-Blixt, C., Haglund, A. Lancet (2006) [Pubmed]
  9. Hypovitaminosis D and hyperparathyroidism in physically inactive elderly Japanese living in nursing homes: relationship with age, sunlight exposure and activities of daily living. Nashimoto, M., Nakamura, K., Matsuyama, S., Hatakeyama, M., Yamamoto, M. Aging clinical and experimental research. (2002) [Pubmed]
  10. The prevalence of psychiatric morbidity among adults living in institutions. Meltzer, H., Gill, B., Hinds, K., Petticrew, M. International review of psychiatry (Abingdon, England) (2003) [Pubmed]
  11. Effects of residence in Alzheimer disease special care units on functional outcomes. Phillips, C.D., Sloane, P.D., Hawes, C., Koch, G., Han, J., Spry, K., Dunteman, G., Williams, R.L. JAMA (1997) [Pubmed]
  12. The impact of Medicare's prospective payment system on Wisconsin nursing homes. Sager, M.A., Leventhal, E.A., Easterling, D.V. JAMA (1987) [Pubmed]
  13. Benefit-risk considerations in preventive treatment for tuberculosis in elderly persons. Stead, W.W., To, T., Harrison, R.W., Abraham, J.H. Ann. Intern. Med. (1987) [Pubmed]
  14. Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population. Sheu, K.F., Brown, A.M., Haroutunian, V., Kristal, B.S., Thaler, H., Lesser, M., Kalaria, R.N., Relkin, N.R., Mohs, R.C., Lilius, L., Lannfelt, L., Blass, J.P. Ann. Neurol. (1999) [Pubmed]
  15. Comprehensive strategy to prevent nosocomial spread of methicillin-resistant Staphylococcus aureus in a highly endemic setting. Tomic, V., Svetina Sorli, P., Trinkaus, D., Sorli, J., Widmer, A.F., Trampuz, A. Arch. Intern. Med. (2004) [Pubmed]
  16. Ciprofloxacin-resistant methicillin-resistant Staphylococcus aureus in New York health care facilities, 1988. The New York MRSA Study Group. Budnick, L.D., Schaefler, S. American journal of public health. (1990) [Pubmed]
  17. Effects on bone mineral density of calcium and vitamin D supplementation in elderly women with vitamin D deficiency. Grados, F., Brazier, M., Kamel, S., Duver, S., Heurtebize, N., Maamer, M., Mathieu, M., Garabédian, M., Sebert, J.L., Fardellone, P. Joint, bone, spine : revue du rhumatisme. (2003) [Pubmed]
  18. Caries incidence and increments in Adelaide nursing home residents. Chalmers, J.M., Carter, K.D., Spencer, A.J. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. (2005) [Pubmed]
  19. Prevention of hip fractures by correcting calcium and vitamin D insufficiencies in elderly people. Meunier, P. Scand. J. Rheumatol. Suppl. (1996) [Pubmed]
  20. Mupirocin-based decolonization of Staphylococcus aureus carriers in residents of 2 long-term care facilities: a randomized, double-blind, placebo-controlled trial. Mody, L., Kauffman, C.A., McNeil, S.A., Galecki, A.T., Bradley, S.F. Clin. Infect. Dis. (2003) [Pubmed]
  21. Tacrine use in nursing homes: implications for prescribing new cholinesterase inhibitors. SAGE Study Group. Systematic Assessment of Geriatric Drug Use via Epidemiology. Gifford, D.R., Lapane, K.L., Gambassi, G., Landi, F., Mor, V., Bernabei, R. Neurology (1999) [Pubmed]
  22. High prevalence of low femoral bone mineral density in elderly women living in nursing homes or community-dwelling: a plausible role of increased parathyroid hormone secretion. Reginster, J.Y., Deroisy, R., Pirenne, H., Frederick, I., Dewe, W., Albert, A., Collette, J., Zheng, S.X., Gosset, C. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1999) [Pubmed]
  23. Methicillin-resistant Staphylococcus aureus colonization in a long-term-care facility. Murphy, S., Denman, S., Bennett, R.G., Greenough, W.B., Lindsay, J., Zelesnick, L.B. Journal of the American Geriatrics Society. (1992) [Pubmed]
  24. Methicillin-resistant Staphylococcus aureus and infection control for restorative dental treatment in nursing homes. Hall, D.L. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. (2003) [Pubmed]
  25. Arginine supplementation is well tolerated but does not enhance mitogen-induced lymphocyte proliferation in elderly nursing home residents with pressure ulcers. Langkamp-Henken, B., Herrlinger-Garcia, K.A., Stechmiller, J.K., Nickerson-Troy, J.A., Lewis, B., Moffatt, L. JPEN. Journal of parenteral and enteral nutrition. (2000) [Pubmed]
  26. The emergence of methicillin-resistant Staphylococcus aureus infections in United States hospitals. Possible role of the house staff-patient transfer circuit. Haley, R.W., Hightower, A.W., Khabbaz, R.F., Thornsberry, C., Martone, W.J., Allen, J.R., Hughes, J.M. Ann. Intern. Med. (1982) [Pubmed]
  27. Amantadine-resistant influenza A in nursing homes. Identification of a resistant virus prior to drug use. Houck, P., Hemphill, M., LaCroix, S., Hirsh, D., Cox, N. Arch. Intern. Med. (1995) [Pubmed]
  28. Effects of angiotensin-converting enzyme inhibitors and digoxin on health outcomes of very old patients with heart failure. SAGE Study Group. Systematic Assessment of Geriatric drug use via Epidemiology. Gambassi, G., Lapane, K.L., Sgadari, A., Carbonin, P., Gatsonis, C., Lipsitz, L.A., Mor, V., Bernabei, R. Arch. Intern. Med. (2000) [Pubmed]
  29. Withdrawal of haloperidol, thioridazine, and lorazepam in the nursing home: a controlled, double-blind study. Cohen-Mansfield, J., Lipson, S., Werner, P., Billig, N., Taylor, L., Woosley, R. Arch. Intern. Med. (1999) [Pubmed]
  30. Effect of apolipoprotein E genotype on Alzheimer's disease neuropathology in a cohort of elderly Norwegians. Morris, C.M., Benjamin, R., Leake, A., McArthur, F.K., Candy, J.M., Ince, P.G., Torvik, A., Bjertness, E., Edwardson, J.A. Neurosci. Lett. (1995) [Pubmed]
  31. The effect of equipment usage and residual task difficulty on use of personal assistance, days in bed, and nursing home placement. Taylor, D.H., Hoenig, H. Journal of the American Geriatrics Society. (2004) [Pubmed]
  32. Contrasting methicillin-resistant Staphylococcus aureus colonization in Veterans Affairs and community nursing homes. Mulhausen, P.L., Harrell, L.J., Weinberger, M., Kochersberger, G.G., Feussner, J.R. Am. J. Med. (1996) [Pubmed]
  33. Nursing home characteristics associated with tube feeding in advanced cognitive impairment. Mitchell, S.L., Kiely, D.K., Gillick, M.R. Journal of the American Geriatrics Society. (2003) [Pubmed]
  34. The prevalence of fecal colonization with VRE among residents of long-term-care facilities in Melbourne, Australia. Padiglione, A.A., Grabsch, E., Wolfe, R., Gibson, K., Grayson, M.L. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2001) [Pubmed]
  35. Sex-specific and race-specific hip fracture rates. Kellie, S.E., Brody, J.A. American journal of public health. (1990) [Pubmed]
  36. Rehabilitation services after the implementation of the nursing home prospective payment system: differences related to patient and nursing home characteristics. Murray, P.K., Love, T.E., Dawson, N.V., Thomas, C.L., Cebul, R.D. Medical care. (2005) [Pubmed]
  37. Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. Flicker, L., MacInnis, R.J., Stein, M.S., Scherer, S.C., Mead, K.E., Nowson, C.A., Thomas, J., Lowndes, C., Hopper, J.L., Wark, J.D. Journal of the American Geriatrics Society. (2005) [Pubmed]
  38. Outbreaks of influenza A and B in a highly immunized nursing home population. Drinka, P.J., Gravenstein, S., Krause, P., Schilling, M., Miller, B.A., Shult, P. The Journal of family practice. (1997) [Pubmed]
  39. Factors affecting survival of elderly nursing home residents. Dale, M.C., Burns, A., Panter, L., Morris, J. International journal of geriatric psychiatry. (2001) [Pubmed]
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