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Chemical Compound Review

Ercalcidiol     (E,3S,6S)-6-[(1R,3aR,4E,7aR)- 4-[(2Z)-2...

Synonyms: CS-0393, AC1NWQ5Z, HY-32349, LMST03010030, LS-187060, ...
 
 
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Disease relevance of 25-HYDROXYVITAMIN D2

 

Psychiatry related information on 25-HYDROXYVITAMIN D2

 

High impact information on 25-HYDROXYVITAMIN D2

 

Chemical compound and disease context of 25-HYDROXYVITAMIN D2

 

Biological context of 25-HYDROXYVITAMIN D2

  • Seasonal variations of serum 25OHD were noted only in the control population; in this group the 25OHD levels also correlated with sunlight exposure (r = 0.48; P less than 0.01), as assessed by an outdoor score [10].
  • Women with low 25OHD had a reduced vertebral bone density (VBD), assessed by quantitative computed tomography, compared to age-matched controls (P less than 0.001) [10].
  • To provide further data on vitamin D metabolism in pregnancy, the concentrations of 25-hydroxyvitamin D (25OHD; n = 72), 24,25-dihydroxyvitamin D [24,25-(OH)2D; n = 70], and 1,25-(OH)2D (n = 59) were measured in amniotic fluid by competitive protein-binding radioassays [11].
  • In multiple regression analysis 50-60% of the variation of total and free 1,25-(OH)2D could be explained by serum 25OHD, PTH(1-84), and especially IGF-I, suggesting a possible role of decreasing GH and IGF-I concentrations in the mineral homeostasis of the elderly [12].
  • At term, the mean (+/- SE) concentrations of 25OHD and 24,25-(OH)2D in amniotic fluid (810 +/- 76 and 37.5 +/- 5.4 pg/ml, respectively) were significantly lower (P less than 0.01) than those at 16-18 weeks gestation (1707 +/- 2.67 and 149 +/- 3 pg/ml, respectively) [11].
 

Anatomical context of 25-HYDROXYVITAMIN D2

 

Associations of 25-HYDROXYVITAMIN D2 with other chemical compounds

 

Gene context of 25-HYDROXYVITAMIN D2

  • In multivariate analyses that also corrected for balance and health status, PTH remained a significant predictor of falls independent of 25OHD [2].
  • At 12 weeks of age (40-42 weeks postconceptual age), DBP, 25-hydroxyvitamin D (25OHD), calcium, phosphorus, copper, and albumin were all significantly increased (by paired t test) [22].
  • The mean 25OHD level in the March sample (39.9 nmol/L, SD 19.7) was significantly lower than the mean 25OHD level in the September sample (44.9 nmol/L, SD 16.9) (P = .001) [23].
  • Baseline patient characteristics including: age, basal serum 25-hydroxyvitamin D (25OHD), basal serum PTH, basal serum calcium and post treatment serum calcium, were similar in groups N and F. Mild hypercalcaemia occurred in only two (3.9%) patients [24].
  • In the entire group, serum ionized calcium (Ca2+), bone gla protein (BGP), 25-hydroxyvitamin D (25OHD), and 1,25-dihydroxyvitamin D (1,25(OH)2D) were all lower than in age-matched controls, and carboxy-terminal parathyroid hormone (CPTH) was higher [25].
 

Analytical, diagnostic and therapeutic context of 25-HYDROXYVITAMIN D2

  • Serum PTH was measured by means of 2 immunoradiometric assays, the Allegro intact PTH assay (Nichols Institute Diagnostics) and the new CAP assay (Scantibodies Laboratory, Inc.). We found a high prevalence (167 of 280; 59.6%) of low 25OHD (< or =30 nmol/L) in these otherwise healthy individuals [26].
  • BMD at the lumbar spine was correlated with body mass index (BMI) (r = 0.278, p = 0.0003), age (r = -0.194, p = 0.0134) and serum 25OHD (r = 0.188, p = 0.0167) [27].
  • METHODS: Cross-sectional study of 378 healthy, middle-aged and older community-dwelling men in Auckland, New Zealand. RESULTS: The mean 25OHD (SD) level was 85 (31) nmol/l. We found significant seasonal variation in 25OHD levels (peak in autumn 103 nmol/l, nadir in spring 59 nmol/l) [6].
  • Our results showed a baseline mean 25OHD level in the active group of 9.6 (range < 5.5-12.7) ng/ml and in the control group of 10.0 (range < 5.5-12.9) ng/ml (P < 0.4) [28].
  • A dose-response relationship in serum 25OHD levels was observed for sunbathing frequency before and after adjusting for age (P< 0.05) [29].

References

  1. Postoperative tetany in Graves disease: important role of vitamin D metabolites. Yamashita, H., Murakami, T., Noguchi, S., Shiiba, M., Watanabe, S., Uchino, S., Kawamoto, H., Toda, M., Murakami, N. Ann. Surg. (1999) [Pubmed]
  2. Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. Sambrook, P.N., Chen, J.S., March, L.M., Cameron, I.D., Cumming, R.G., Lord, S.R., Zochling, J., Sitoh, Y.Y., Lau, T.C., Schwarz, J., Seibel, M.J. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  3. Resolution of vitamin D insufficiency in osteopenic patients results in rapid recovery of bone mineral density. Adams, J.S., Kantorovich, V., Wu, C., Javanbakht, M., Hollis, B.W. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  4. Abnormal vitamin D metabolism in the X-linked hypophosphatemic mouse. Meyer, R.A., Gray, R.W., Meyer, M.H. Endocrinology (1980) [Pubmed]
  5. Role of vitamin D and parathyroid hormone in the regulation of bone turnover and bone mass in men: the MINOS study. Szulc, P., Munoz, F., Marchand, F., Chapuy, M.C., Delmas, P.D. Calcif. Tissue Int. (2003) [Pubmed]
  6. Determinants of vitamin D status in older men living in a subtropical climate. Bolland, M.J., Grey, A.B., Ames, R.W., Mason, B.H., Horne, A.M., Gamble, G.D., Reid, I.R. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2006) [Pubmed]
  7. An in vitro study of vitamin D2 hydroxylases in the chick. Jones, G., Schnoes, H.K., DeLuca, H.F. J. Biol. Chem. (1976) [Pubmed]
  8. Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status. Dhesi, J.K., Bearne, L.M., Moniz, C., Hurley, M.V., Jackson, S.H., Swift, C.G., Allain, T.J. J. Bone Miner. Res. (2002) [Pubmed]
  9. Bone mineral density increases with vitamin D repletion in patients with coexistent vitamin D insufficiency and primary hyperparathyroidism. Kantorovich, V., Gacad, M.A., Seeger, L.L., Adams, J.S. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  10. Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass. Villareal, D.T., Civitelli, R., Chines, A., Avioli, L.V. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  11. Vitamin D metabolites in amniotic fluid. Lazebnik, R., Eisenberg, Z., Lazebnik, N., Spirer, Z., Weisman, Y. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  12. Influence of vitamin D on parathyroid function in the elderly. Quesada, J.M., Coopmans, W., Ruiz, B., Aljama, P., Jans, I., Bouillon, R. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  13. Biological activity of 1,25-dihydroxyvitamin D2 in the chick. Jones, G., Baxter, L.A., DeLuca, H.F., Schnoes, H.K. Biochemistry (1976) [Pubmed]
  14. Determinants of vitamin D status in older women living in a subtropical climate. Lucas, J.A., Bolland, M.J., Grey, A.B., Ames, R.W., Mason, B.H., Horne, A.M., Gamble, G.D., Reid, I.R. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2005) [Pubmed]
  15. Vitamin D status of an outpatient clinic population. Margiloff, L., Harris, S.S., Lee, S., Lechan, R., Dawson-Hughes, B. Calcif. Tissue Int. (2001) [Pubmed]
  16. Individual quantitation of vitamin D2, vitamin D3, 25-hydroxyvitamin D2, and 25-hydroxyvitamin D3 in human milk. Hollis, B.W. Anal. Biochem. (1983) [Pubmed]
  17. Vitamin D supplementation in postmenopausal black women. Kyriakidou-Himonas, M., Aloia, J.F., Yeh, J.K. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  18. Effect of vitamin D nutrition on parathyroid adenoma weight: pathogenetic and clinical implications. Rao, D.S., Honasoge, M., Divine, G.W., Phillips, E.R., Lee, M.W., Ansari, M.R., Talpos, G.B., Parfitt, A.M. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  19. Assay for plasma 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 by "high-performance" liquid chromatography. Dabek, J.T., Härkönen, M., Wahlroos, O., Adlercreutz, H. Clin. Chem. (1981) [Pubmed]
  20. HPLC method for 25-hydroxyvitamin D measurement: comparison with contemporary assays. Lensmeyer, G.L., Wiebe, D.A., Binkley, N., Drezner, M.K. Clin. Chem. (2006) [Pubmed]
  21. Assessment of a two-step high-performance liquid chromatographic assay using dual-wavelength ultraviolet monitoring for 25-hydroxyergocalciferol and 25-hydroxycholecalciferol in human serum or plasma. Norris, R.L., Thomas, M.J., Craswell, P.W. J. Chromatogr. (1986) [Pubmed]
  22. Serial analyses of serum vitamin D-binding protein in preterm infants from birth to postconceptual maturity. Hillman, L.S., Haddad, J.G. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  23. Seasonal prevalence of vitamin D deficiency in institutionalized older adults. Liu, B.A., Gordon, M., Labranche, J.M., Murray, T.M., Vieth, R., Shear, N.H. Journal of the American Geriatrics Society. (1997) [Pubmed]
  24. Failure to normalize parathyroid hormone during treatment of vitamin D deficiency in Asian patients. Peacey, S.R., Wright, D., Harries, M.J. Clin. Endocrinol. (Oxf) (2004) [Pubmed]
  25. Alteration in osteoblast activity and nutritional vitamin-D deficiency in non-hypercalcemic malignancy. Jowell, P.S., Epstein, S., Ismail, F., Hollis, B., Schwartz, I.R. Calcif. Tissue Int. (1988) [Pubmed]
  26. Vitamin D status and redefining serum parathyroid hormone reference range in the elderly. Souberbielle, J.C., Cormier, C., Kindermans, C., Gao, P., Cantor, T., Forette, F., Baulieu, E.E. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  27. Vitamin D and bone mineral density. Collins, D., Jasani, C., Fogelman, I., Swaminathan, R. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1998) [Pubmed]
  28. Vitamin D-fortified liquid milk: benefits for the elderly community-based population. Keane, E.M., Healy, M., O'Moore, R., Coakley, D., Walsh, J.B. Calcif. Tissue Int. (1998) [Pubmed]
  29. Vitamin D status of women in the Geelong Osteoporosis Study: association with diet and casual exposure to sunlight. Pasco, J.A., Henry, M.J., Nicholson, G.C., Sanders, K.M., Kotowicz, M.A. Med. J. Aust. (2001) [Pubmed]
 
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