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Chemical Compound Review

Calderol     (6R)-6-[(1R,4E,7aR)-4-[(2Z)- 2-[(5R)-5...

Synonyms: Delakmin, Calcifidiol, CHEMBL1040, CHEMBL1222, S1469_Selleck, ...
 
 
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Disease relevance of Calcidiol

 

Psychiatry related information on Calcidiol

  • MEASUREMENTS: Intake of vitamin D and serum levels of 25-hydroxyvitamin D, calculated on the basis of dietary habits and supplement use as reported on a questionnaire, were evaluated at examination 20 (1988 to 1989) [6].
  • MATERIALS AND METHODS: We studied 3100 women (50-63 years old) with bone markers, 25-hydroxyvitamin D, calcium, PTH, diet, and physical activity collected in 1998-2000 [7].
  • However, in an analysis restricted to men with plasma 25-hydroxyvitamin D below the median, we observed a 57% reduction (RR = 0.43, 95% CI = 0.19-0.98) in risk for those with the BB versus the bb genotype; the risk reduction was particularly marked among older men (RR = 0.18, 95% CI = 0.05-0.68) [8].
  • This relationship remained significant after adjustment for testosterone, estradiol, 25-hydroxyvitamin D, and parathyroid hormone levels (r = 0.22, P = 0.01) and after additional adjustment for age, (BM), activity, cigarette and alcohol consumption, and Kellgren/Lawrence score (r = 0.19, P = 0.03) [9].
  • Each subject had a dietary assessment, mental test score, outdoor score, serum 25 hydroxyvitamin D level, and a general biochemical screening at baseline in April 1993 which was repeated in September 1993, April 1994, and September 1994 [10].
 

High impact information on Calcidiol

 

Chemical compound and disease context of Calcidiol

 

Biological context of Calcidiol

 

Anatomical context of Calcidiol

 

Associations of Calcidiol with other chemical compounds

 

Gene context of Calcidiol

 

Analytical, diagnostic and therapeutic context of Calcidiol

References

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  2. Treatment of hypoparathyroidism and pseudohypoparathyroidism with metabolites of vitamin D: evidence for impaired conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D. Kooh, S.W., Fraser, D., DeLuca, H.F., Holick, M.F., Belsey, R.E., Clark, M.B., Murray, T.M. N. Engl. J. Med. (1975) [Pubmed]
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  4. Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration. Hahn, T.J., Halstead, L.R., Teitelbaum, S.L., Hahn, B.H. J. Clin. Invest. (1979) [Pubmed]
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  7. Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women. Macdonald, H.M., McGuigan, F.E., Stewart, A., Black, A.J., Fraser, W.D., Ralston, S., Reid, D.M. J. Bone Miner. Res. (2006) [Pubmed]
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  11. Hypovitaminosis D in medical inpatients. Thomas, M.K., Lloyd-Jones, D.M., Thadhani, R.I., Shaw, A.C., Deraska, D.J., Kitch, B.T., Vamvakas, E.C., Dick, I.M., Prince, R.L., Finkelstein, J.S. N. Engl. J. Med. (1998) [Pubmed]
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  13. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. Berndt, T., Craig, T.A., Bowe, A.E., Vassiliadis, J., Reczek, D., Finnegan, R., Jan De Beur, S.M., Schiavi, S.C., Kumar, R. J. Clin. Invest. (2003) [Pubmed]
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  22. The transport of vitamin D and its 25-hydroxy metabolite in human plasma. Isolation and partial characterization of vitamin D and 25-hydroxyvitamin D binding protein. Imawari, M., Kida, K., Goodman, D.S. J. Clin. Invest. (1976) [Pubmed]
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  28. 25-Hydroxyvitamin D and vitamin D in human milk: effects of supplementation and season. Ala-Houhala, M., Koskinen, T., Parviainen, M.T., Visakorpi, J.K. Am. J. Clin. Nutr. (1988) [Pubmed]
  29. Body fat content and 25-hydroxyvitamin D levels in healthy women. Arunabh, S., Pollack, S., Yeh, J., Aloia, J.F. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
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  33. Detection of genetic variation with radioactive ligands. II. Genetic variants of vitamin D-labeled group-specific component (Gc) proteins. Daiger, S.P., Cavalli-Sforza, L.L. Am. J. Hum. Genet. (1977) [Pubmed]
  34. 25-Hydroxyvitamin D transport in human plasma. Isolation and partial characterization of calcifidiol-binding protein. Haddad, J.G., Walgate, J. J. Biol. Chem. (1976) [Pubmed]
  35. 25-hydroxyvitamin D hydroxylation. Evidence for a dioxygenase activity of solubilized renal mitochondrial cytochrome P-450. Warner, M. J. Biol. Chem. (1983) [Pubmed]
  36. Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Cheng, J.B., Levine, M.A., Bell, N.H., Mangelsdorf, D.J., Russell, D.W. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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  38. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. St-Arnaud, R., Messerlian, S., Moir, J.M., Omdahl, J.L., Glorieux, F.H. J. Bone Miner. Res. (1997) [Pubmed]
  39. Calcium supplementation suppresses bone turnover during weight reduction in postmenopausal women. Ricci, T.A., Chowdhury, H.A., Heymsfield, S.B., Stahl, T., Pierson, R.N., Shapses, S.A. J. Bone Miner. Res. (1998) [Pubmed]
  40. Role of calciotrophic hormones in calcium mobilization of lactation. Sowers, M., Zhang, D., Hollis, B.W., Shapiro, B., Janney, C.A., Crutchfield, M., Schork, M.A., Stanczyk, F., Randolph, J. Am. J. Clin. Nutr. (1998) [Pubmed]
  41. Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. Halloran, B.P., Bikle, D.D., Levens, M.J., Castro, M.E., Globus, R.K., Holton, E. J. Clin. Invest. (1986) [Pubmed]
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