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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells.

PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4- induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.[1]

References

  1. Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells. Göke, R., Gregel, C., Göke, A., Arnold, R., Schmidt, H., Lankat-Buttgereit, B. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
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