Gene Review:
PDCD4 - programmed cell death 4 (neoplastic...
Homo sapiens
Synonyms:
H731, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Programmed cell death protein 4, Protein 197/15a
- Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells. Göke, R., Gregel, C., Göke, A., Arnold, R., Schmidt, H., Lankat-Buttgereit, B. Ann. N. Y. Acad. Sci. (2004)
- Programmed cell death-4 tumor suppressor protein contributes to retinoic Acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Ozpolat, B., Akar, U., Steiner, M., Zorrilla-Calancha, I., Tirado-Gomez, M., Colburn, N., Danilenko, M., Kornblau, S., Lopez Berestein, G. Mol. Cancer Res. (2007)
- Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). Göke, R., Barth, P., Schmidt, A., Samans, B., Lankat-Buttgereit, B. Am. J. Physiol., Cell Physiol. (2004)
- Frequent loss of PDCD4 expression in human glioma: Possible role in the tumorigenesis of glioma. Gao, F., Zhang, P., Zhou, C., Li, J., Wang, Q., Zhu, F., Ma, C., Sun, W., Zhang, L. Oncol. Rep. (2007)
- Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Leupold, J.H., Yang, H.S., Colburn, N.H., Asangani, I., Post, S., Allgayer, H. Oncogene (2007)
- Structural basis for inhibition of translation by the tumor suppressor Pdcd4. LaRonde-LeBlanc, N., Santhanam, A.N., Baker, A.R., Wlodawer, A., Colburn, N.H. Mol. Cell. Biol. (2007)
- Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Yang, H.S., Matthews, C.P., Clair, T., Wang, Q., Baker, A.R., Li, C.C., Tan, T.H., Colburn, N.H. Mol. Cell. Biol. (2006)
- A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Yang, H.S., Cho, M.H., Zakowicz, H., Hegamyer, G., Sonenberg, N., Colburn, N.H. Mol. Cell. Biol. (2004)
- Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. Palamarchuk, A., Efanov, A., Maximov, V., Aqeilan, R.I., Croce, C.M., Pekarsky, Y. Cancer Res. (2005)
- Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis. Afonja, O., Juste, D., Das, S., Matsuhashi, S., Samuels, H.H. Oncogene (2004)
- Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity. Jansen, A.P., Camalier, C.E., Stark, C., Colburn, N.H. Mol. Cancer Ther. (2004)
- Up-regulation of PDCD4 in senescent human diploid fibroblasts. Kang, M.J., Ahn, H.S., Lee, J.Y., Matsuhashi, S., Park, W.Y. Biochem. Biophys. Res. Commun. (2002)
- Assignment of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization. Soejima, H., Miyoshi, O., Yoshinaga, H., Masaki, Z., Ozaki, I., Kajiwara, S., Niikawa, N., Matsuhashi, S., Mukai, T. Cytogenet. Cell Genet. (1999)
- Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma. Zhang, H., Ozaki, I., Mizuta, T., Hamajima, H., Yasutake, T., Eguchi, Y., Ideguchi, H., Yamamoto, K., Matsuhashi, S. Oncogene (2006)
- Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. Yoshinaga, H., Matsuhashi, S., Fujiyama, C., Masaki, Z. Pathol. Int. (1999)
- Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. Hilliard, A., Hilliard, B., Zheng, S.J., Sun, H., Miwa, T., Song, W., G??ke, R., Chen, Y.H. J. Immunol. (2006)
- Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II. Lankat-Buttgereit, B., Gregel, C., Knolle, A., Hasilik, A., Arnold, R., Göke, R. Mol. Cell. Endocrinol. (2004)
- Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway. Carayol, N., Katsoulidis, E., Sassano, A., Altman, J.K., Druker, B.J., Platanias, L.C. J. Biol. Chem. (2008)
- Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. Zakowicz, H., Yang, H.S., Stark, C., Wlodawer, A., Laronde-Leblanc, N., Colburn, N.H. RNA (2005)
- Potential markers of tongue tumor progression selected by cDNA microarray. Carinci, F., Lo Muzio, L., Piattelli, A., Rubini, C., Chiesa, F., Ionna, F., Palmieri, A., Maiorano, E., Pastore, A., Laino, G., Dolci, M., Pezzetti, F. International journal of immunopathology and pharmacology. (2005)
- Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. Zhang, Z., DuBois, R.N. Oncogene (2001)
- Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. Chen, Y., Knösel, T., Kristiansen, G., Pietas, A., Garber, M.E., Matsuhashi, S., Ozaki, I., Petersen, I. J. Pathol. (2003)