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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Does constitutive phosphorylation protect against photoreceptor degeneration in Rpe65-/- mice?

Despite the presence of this virgin opsin, Rpe65-/- rods are behaving like dark-adapted rods. These results argue that opsin which has not been exposed to 11-cis retinal and is constitutively phosphorylated, does not generate the activity generally associated with the bleached apoprotein. However, increased light-independent activation of transducin (due to bleached opsin) could be demonstrated after the addition of exogenous 11-cis retinal. We hypothesize that free opsin in the Rpe65-/- rods does not cause degeneration of rods by constitutive activation of the phototransduction cascade; but rather rods may die due to other causes such as the impairment of RPE function due to excess unprocessed retinyl-esters in the RPE.[1]

References

  1. Does constitutive phosphorylation protect against photoreceptor degeneration in Rpe65-/- mice? Rohrer, B., Ablonczy, Z., Znoiko, S., Redmond, M., Ma, J.X., Crouch, R. Adv. Exp. Med. Biol. (2003) [Pubmed]
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