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Mahkam, M. et al.

Mahkam, Allahverdipoor,

Controlled release of biomolecules from pH-sensitive network polymers prepared by radiation polymerization.

Copolymers of 2-hydroxyethyl methacrylate (HEMA) and methacrylic acid (MAA) based hydrogels containing 5 and 10% of a cross-linking agent were studied as drug delivery systems. Terephthalic acid was covalently linked with HEMA, abbreviated as CA. Radiation copolymerization of HEMA and MAA, mixed with a particulate glibenclamide with the various ratios CA as crosslinking agent were carried out at the room temperature. The structure of the CA was confirmed by FTIR, H NMR and C NMR spectroscopy. The compositions of the cross-linked three-dimensional polymers were determined by FTIR spectroscopy. Glass transition temperature (T) of the network polymers was determined calorimetrically. The hydrolysis of drug-polymer conjugates was carried out in cellophane membrane dialysis bags containing an aqueous buffer solution (pH 7.4 and pH 1) at 37 degree C. The drug-release profiles indicate that amount drug release depends on their degree of swelling and cross-linking.[1]

References

Controlled release of biomolecules from pH-sensitive network polymers prepared by radiation polymerization. Mahkam, M., Allahverdipoor, M. Journal of drug targeting. (2004) [Pubmed]

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