- Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB. Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H., Hamanishi, C. Osteoarthr. Cartil. (2004)