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Gene Review

OLR1  -  oxidized low density lipoprotein (lectin...

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Disease relevance of OLR1


High impact information on OLR1


Chemical compound and disease context of OLR1


Biological context of OLR1

  • To provide support for the hypothesis that SNP 8,232 is responsible for OLR1 expression, OLR1 expression levels in individuals bearing different genotypes were assessed [7].
  • Direct cDNA and genomic sequencing of OLR1 revealed 2 single nucleotide polymorphisms (SNP) in exon 4, 5 SNP in intron 4, and 1 in the 3' untranslated region (UTR) [7].
  • The role of OLR1 in lipid metabolism and the results of previous whole-genome scan studies prompted the investigation of OLR1 as a candidate gene affecting milk composition traits [7].
  • Taken together, N-linked glycosylation appears to play key roles in the cell-surface expression and ligand binding of LOX-1 [1].
  • Lectin-like oxidized LDL receptor-1 (LOX-1) is a type II membrane protein belonging to the C-type lectin family molecules, which can act as a cell-surface endocytosis receptor for atherogenic oxidized LDL [8].

Anatomical context of OLR1


Associations of OLR1 with chemical compounds

  • Furthermore, when treated with an N-glycosylation inhibitor, tunicamycin, both tumor necrosis factor-alpha-activated bovine aortic endothelial cells and CHO-K1 cells stably expressing bovine LOX-1 (BLOX-1-CHO) exclusively produced a 32-kDa deglycosylated form of LOX-1 [1].
  • In this study, we show, by pulse-chase labeling and glycosidase digestion, that LOX-1 is synthesized as a 40-kDa precursor protein with N-linked high mannose carbohydrate chains (pre-LOX-1), which is subsequently further glycosylated and processed into the 48-kDa mature form within 40 min [1].
  • Inhibition of de novo RNA synthesis by actinomycin D totally abolished shear stress-induced LOX-1 mRNA expression [12].
  • Chinese hamster ovary K1 cells stably expressing LOX-1 internalized 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI)-labeled Ox-LDL but did not significantly internalize acetylated LDL (Ac-LDL), which was effectively suppressed by excess amounts of unlabeled Ox-LDL but not by Ac-LDL [5].
  • Chelation of intracellular Ca2+ with quin 2-AM completely reduced shear stress-induced LOX-1 mRNA expression; furthermore, the treatment of BAECs with ionomycin upregulated LOX-1 mRNA levels in a dose-dependent manner [12].

Regulatory relationships of OLR1


Other interactions of OLR1


Analytical, diagnostic and therapeutic context of OLR1


  1. Biosynthesis and post-translational processing of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). N-linked glycosylation affects cell-surface expression and ligand binding. Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N., Kita, T. J. Biol. Chem. (2000) [Pubmed]
  2. LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T., Yonehara, S. J. Immunol. (2001) [Pubmed]
  3. Cyclic tensile stretch load and oxidized low density lipoprotein synergistically induce lectin-like oxidized ldl receptor-1 in cultured bovine chondrocytes, resulting in decreased cell viability and proteoglycan synthesis. Akagi, M., Nishimura, S., Yoshida, K., Kakinuma, T., Sawamura, T., Munakata, H., Hamanishi, C. J. Orthop. Res. (2006) [Pubmed]
  4. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T., Masaki, T. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Kume, N., Murase, T., Moriwaki, H., Aoyama, T., Sawamura, T., Masaki, T., Kita, T. Circ. Res. (1998) [Pubmed]
  6. Redox-sensitive regulation of lox-1 gene expression in vascular endothelium. Nagase, M., Ando, K., Nagase, T., Kaname, S., Sawamura, T., Fujita, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. Association of the OLR1 gene with milk composition in Holstein dairy cattle. Khatib, H., Leonard, S.D., Schutzkus, V., Luo, W., Chang, Y.M. J. Dairy Sci. (2006) [Pubmed]
  8. Identification of soluble forms of lectin-like oxidized LDL receptor-1. Murase, T., Kume, N., Kataoka, H., Minami, M., Sawamura, T., Masaki, T., Kita, T. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  9. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). Jono, T., Miyazaki, A., Nagai, R., Sawamura, T., Kitamura, T., Horiuchi, S. FEBS Lett. (2002) [Pubmed]
  10. Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized LDL receptor-1 in vascular smooth muscle cells. Mukai, E., Kume, N., Hayashida, K., Minami, M., Yamada, Y., Seino, Y., Kita, T. Atherosclerosis (2004) [Pubmed]
  11. Peroxisome proliferator-activated receptor alpha ligands activate transcription of lectin-like oxidized low density lipoprotein receptor-1 gene through GC box motif. Hayashida, K., Kume, N., Minami, M., Inui-Hayashida, A., Mukai, E., Toyohara, M., Kita, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  12. Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Murase, T., Kume, N., Korenaga, R., Ando, J., Sawamura, T., Masaki, T., Kita, T. Circ. Res. (1998) [Pubmed]
  13. Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma. Kanata, S., Akagi, M., Nishimura, S., Hayakawa, S., Yoshida, K., Sawamura, T., Munakata, H., Hamanishi, C. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  14. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) supports cell adhesion to fibronectin. Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T., Yonehara, S. FEBS Lett. (2001) [Pubmed]
  15. Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB. Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H., Hamanishi, C. Osteoarthr. Cartil. (2004) [Pubmed]
  16. Peroxisome proliferator-activated receptor a ligands increase lectin-like oxidized low density lipoprotein receptor-1 expression in vascular endothelial cells. Hayashida, K., Kume, N., Minami, M., Kataoka, H., Morimoto, M., Kita, T. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
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