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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cyclosporine A-induced ocular opsoclonus and reversible leukoencephalopathy after orthotopic liver transplantation: brief report.

Ocular opsoclonus is a rare neurologic condition that occurs in patients with brain stem encephalitis, neoplasm of the mesencephalon, paraneoplastic syndrome or intoxication. Neurotoxicity is a well-known complication of cyclosporine-A (CSA) therapy. We report a case of a 17-year-old patient, a Caucasian female, who underwent an orthotopic liver transplantation (OLT) for immunologic cirrhosis and chronic cellular rejection respectively. The ocular symptoms occurred 8 days after the OLT. She also developed reversible posterior leukoencephalopathy. The serum level of CSA was 412 ng/mL. The ocular symptoms improved 21 days after the reduction of the CSA level.[1]

References

  1. Cyclosporine A-induced ocular opsoclonus and reversible leukoencephalopathy after orthotopic liver transplantation: brief report. Marchiori, P.E., Mies, S., Scaff, M. Clinical neuropharmacology. (2004) [Pubmed]
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