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Blazar, B.R. et al.

Blazar, Levy, Mak, Panoskaltsis-Mortari, Muta, Jones, Roskos, Serody, Yagita, Podack, Taylor,

CD30/ CD30 ligand ( CD153) interaction regulates CD4+ T cell- mediated graft-versus-host disease.

CD30, a TNFR family member, is expressed on activated CD4(+) and CD8(+) T cells and B cells and is a marker of Hodgkin's lymphoma; its ligand, CD30L ( CD153) is expressed by activated CD4(+) and CD8(+) T cells, B cells, and macrophages. Signaling via CD30 can lead to proliferation or cell death. CD30-deficient (-/-) mice have impaired thymic negative selection and increased autoreactivity. Although human alloreactive T cells preferentially reside within the CD30(+) T cell subset, implicating CD30 as a regulator of T cell immune responses, the role of CD30/ CD153 in regulating graft-vs-host disease (GVHD) has not been reported. We used a neutralizing anti- CD153 mAb, CD30(-/-) donor mice, and generated CD153(-/-) recipient mice to analyze the effect of CD30/ CD153 interaction on GVHD induction. Our data indicate that the CD30/ CD153 pathway is a potent regulator of CD4(+), but not CD8(+), T cell-mediated GVHD. Although blocking CD30/ CD153 interactions in vivo did not affect alloreactive CD4(+) T cell proliferation or apoptosis, a substantial reduction in donor CD4(+) T cell migration into the gastrointestinal tract was readily observed with lesser effects in other GVHD target organs. Blockade of the CD30/ CD153 pathway represents a new approach for preventing CD4(+) T cell-mediated GVHD.[1]

References

CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. Blazar, B.R., Levy, R.B., Mak, T.W., Panoskaltsis-Mortari, A., Muta, H., Jones, M., Roskos, M., Serody, J.S., Yagita, H., Podack, E.R., Taylor, P.A. J. Immunol. (2004) [Pubmed]

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