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Patel, A. et al.

NF-Kappa-B downregulation strategies in head and neck cancer treatment.

OBJECTIVE: Multiple biochemical and genetic strategies were used to downregulate early response gene NF-KappaB, whose activation controls squamous cell cancer-associated pathways. STUDY DESIGN: NA cells, an oral cavity squamous cell cancer with high NF-KappaB activity, were cultured with biochemical NF-KappaB inhibitors TPCK and Calpain I inhibitor, as well as specific NF-KappaB antisense oligonucleotides. Cell proliferation was measured, as was NF-KappaB downregulation using functional luciferase reporter genes and electromobility shift assays. RESULTS: Significant downregulation of cell proliferation and NF-KappaB functional activity were demonstrated with either biochemical inhibitor, as well as the antisense oligonucleotides; however, additional nonspecific toxicities were observed with control antisense oligonucleotides. CONCLUSION AND SIGNIFICANCE: NF-KappaB is a potential target for squamous cancer treatment, as it is constitutively upregulated in vitro. Biochemical inhibition of NF-KappaB may be a viable treatment strategy for head and neck squamous cancers.[1]

References

NF-Kappa-B downregulation strategies in head and neck cancer treatment. Patel, A., Miller, L., Ahmed, K., Ondrey, F. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2004) [Pubmed]

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