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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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T cell-dependent production of IFN-gamma by NK cells in response to influenza A virus.

The role of human NK cells in viral infections is poorly understood. We used a cytokine flow-cytometry assay to simultaneously investigate the IFN-gamma response of NK and T lymphocytes to influenza A virus (fluA). When PBMCs from fluA-immune adult donors were incubated with fluA, IFN-gamma was produced by both CD56(dim) and CD56(bright) subsets of NK cells, as well as by fluA-specific T cells. Purified NK cells did not produce IFN-gamma in response to fluA, while depletion of T lymphocytes reduced to background levels the fluA-induced IFN-gamma production by NK cells, which indicates that T cells are required for the IFN-gamma response of NK cells. The fluA-induced IFN-gamma production of NK cells was suppressed by anti-IL-2 Ab, while recombinant IL-2 replaced the helper function of T cells for IFN-gamma production by NK cells. This indicates that IL-2 produced by fluA-specific T cells is involved in the T cell-dependent IFN-gamma response of NK cells to fluA. Taken together, these results suggest that at an early stage of recurrent viral infection, NK-mediated innate immunity to the virus is enhanced by preexisting virus-specific T cells.[1]

References

  1. T cell-dependent production of IFN-gamma by NK cells in response to influenza A virus. He, X.S., Draghi, M., Mahmood, K., Holmes, T.H., Kemble, G.W., Dekker, C.L., Arvin, A.M., Parham, P., Greenberg, H.B. J. Clin. Invest. (2004) [Pubmed]
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