The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Metabolic effects of ghrelin and its potential implications in uremia.

Ghrelin is a recently described hormone secreted by the stomach. Ghrelin administration in ad-libitum-fed rodents was shown to increase appetite as well as body weight and body fat content, showing metabolic effects of ghrelin in vivo and suggesting its involvement in the pathogenesis of obesity. However, plasma ghrelin concentration was shown to be inversely correlated with body weight and body fat in people and rodents. Increased plasma ghrelin concentration was also reported during diet-induced weight loss and in malnourished states. These findings suggest that circulating ghrelin is regulated by nutritional state and body fat with a feedback mechanism opposing changes in body composition, with a potential key adaptive role during calorie restriction. Plasma ghrelin concentration was shown to be increased in advanced renal failure and hemodialysis patients. The known metabolic effects of ghrelin and the potential implications of hyperghrelinemia in kidney disease will be discussed in this article.[1]


  1. Metabolic effects of ghrelin and its potential implications in uremia. Barazzoni, R., Zanetti, M., Biolo, G., Guarnieri, G. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. (2005) [Pubmed]
WikiGenes - Universities