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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Lang, K.S. et al.

Lang, Recher, Navarini, Harris, Löhning, Junt, Probst, Hengartner, Zinkernagel,

Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation.

Persistence is a hallmark of infection by viruses such as HIV, hepatitis B virus, hepatitis C virus and LCMV. In the case of LCMV, persistence may often be associated with exhaustion of CD8(+) T cells. We demonstrate here that persistent antigen suppressed IL-7Ralpha expression and this correlated with T cell exhaustion and reduced expression of the anti-apoptotic molecule B cell leukemia/lymphoma 2 (Bcl-2). In contrast, exposure to short-lived antigen only temporarily suppressed IL-7Ralpha expression, failed to induce T cell exhaustion, and primed T cells. Persistent antigen also suppressed IL-7Ralpha expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate.[1]

References

Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation. Lang, K.S., Recher, M., Navarini, A.A., Harris, N.L., Löhning, M., Junt, T., Probst, H.C., Hengartner, H., Zinkernagel, R.M. Eur. J. Immunol. (2005) [Pubmed]

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