- Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. Bai, J., Sui, J., Demirjian, A., Vollmer, C.M., Marasco, W., Callery, M.P. Cancer Res. (2005)