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Gene Review

TNFRSF6B  -  tumor necrosis factor receptor superfamily...

Homo sapiens

Synonyms: DCR3, DJ583P15.1.1, DcR3, Decoy receptor 3, Decoy receptor for Fas ligand, ...
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Disease relevance of TNFRSF6B


High impact information on TNFRSF6B


Chemical compound and disease context of TNFRSF6B


Biological context of TNFRSF6B

  • Sensitization of cells to TRAIL-induced apoptosis by decoy receptor 3 [9].
  • In this study, we discovered a novel function of TR6: inhibition of T cell chemotaxis [10].
  • The enhancement by DcR3 of cell adhesion to HUVECs was not mimicked by the TL1A-Ab, which has been shown in our previous work to be a neutralizing Ab against TL1A, thereby inducing HUVECs angiogenesis [11].
  • Cell death triggered by anti-Fas and tumor necrosis factor was unaffected by DcR3 [9].
  • Together, our data demonstrate that DcR3 increases monocyte adhesion to ECs via NF-kappaB activation, leading to the transcriptional up-regulation of adhesion molecules and IL-8 in ECs [11].

Anatomical context of TNFRSF6B

  • We show that pretreatment of HUVECs with DcR3 enhances the adhesion of THP-1 and U937 cells and primary monocytes [11].
  • Modulation of dendritic cell differentiation and maturation by decoy receptor 3 [1].
  • A similar stimulatory effect of DcR3 on THP-1 adhesion was also observed in human microvascular endothelial cells (HMVECs) [11].
  • We report an unexpected effect of DcR3 by sensitizing Jurkat and U937 cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) [9].
  • Instead, in the presence of DcR3, TRAIL engagement resulted in an increased activation of caspase-8, an elevated cleavage of Bid, and enhanced release of Smac and cytochrome c from mitochondria to cytosol compared with TRAIL alone [9].

Associations of TNFRSF6B with chemical compounds


Physical interactions of TNFRSF6B


Regulatory relationships of TNFRSF6B

  • Moreover, DcR3-induced cell adhesion could be detected in human aortic endothelial cells (ECs) in which TL1A expression is lacking [11].
  • We also demonstrate the ability of DcR3 to stimulate the secretion of IL-8 by HUVECs [11].
  • In the current study, we demonstrate that TR6 can block the lethal activity of FasL in multiple in vitro systems, and extend this finding to an in vivo model of hepatitis [19].

Other interactions of TNFRSF6B


Analytical, diagnostic and therapeutic context of TNFRSF6B


  1. Modulation of dendritic cell differentiation and maturation by decoy receptor 3. Hsu, T.L., Chang, Y.C., Chen, S.J., Liu, Y.J., Chiu, A.W., Chio, C.C., Chen, L., Hsieh, S.L. J. Immunol. (2002) [Pubmed]
  2. Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3. Hsu, M.J., Lin, W.W., Tsao, W.C., Chang, Y.C., Hsu, T.L., Chiu, A.W., Chio, C.C., Hsieh, S.L. Exp. Cell Res. (2004) [Pubmed]
  3. Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis. Roth, W., Isenmann, S., Nakamura, M., Platten, M., Wick, W., Kleihues, P., Bähr, M., Ohgaki, H., Ashkenazi, A., Weller, M. Cancer Res. (2001) [Pubmed]
  4. Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells. Yang, C.R., Wang, J.H., Hsieh, S.L., Wang, S.M., Hsu, T.L., Lin, W.W. Cell Death Differ. (2004) [Pubmed]
  5. Modulation of T-cell responses to alloantigens by TR6/DcR3. Zhang, J., Salcedo, T.W., Wan, X., Ullrich, S., Hu, B., Gregorio, T., Feng, P., Qi, S., Chen, H., Cho, Y.H., Li, Y., Moore, P.A., Wu, J. J. Clin. Invest. (2001) [Pubmed]
  6. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. Bai, C., Connolly, B., Metzker, M.L., Hilliard, C.A., Liu, X., Sandig, V., Soderman, A., Galloway, S.M., Liu, Q., Austin, C.P., Caskey, C.T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Tumor vaccine based on cell surface expression of DcR3/TR6. Shi, G., Mao, J., Yu, G., Zhang, J., Wu, J. J. Immunol. (2005) [Pubmed]
  8. DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer. Mild, G., Bachmann, F., Boulay, J.L., Glatz, K., Laffer, U., Lowy, A., Metzger, U., Reuter, J., Terracciano, L., Herrmann, R., Rochlitz, C. Int. J. Cancer (2002) [Pubmed]
  9. Sensitization of cells to TRAIL-induced apoptosis by decoy receptor 3. Wu, Y.Y., Chang, Y.C., Hsu, T.L., Hsieh, S.L., Lai, M.Z. J. Biol. Chem. (2004) [Pubmed]
  10. Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo. Shi, G., Wu, Y., Zhang, J., Wu, J. J. Immunol. (2003) [Pubmed]
  11. Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-kappa B-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression. Yang, C.R., Hsieh, S.L., Ho, F.M., Lin, W.W. J. Immunol. (2005) [Pubmed]
  12. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Shi, G., Luo, H., Wan, X., Salcedo, T.W., Zhang, J., Wu, J. Blood (2002) [Pubmed]
  13. Increased expression of soluble decoy receptor 3 in acutely inflamed intestinal epithelia. Kim, S., Fotiadu, A., Kotoula, V. Clin. Immunol. (2005) [Pubmed]
  14. Decoy receptor 3 (DcR3) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT. Wroblewski, V.J., Witcher, D.R., Becker, G.W., Davis, K.A., Dou, S., Micanovic, R., Newton, C.M., Noblitt, T.W., Richardson, J.M., Song, H.Y., Hale, J.E. Biochem. Pharmacol. (2003) [Pubmed]
  15. The role of apoptosis in acute lung injury. Martin, T.R., Nakamura, M., Matute-Bello, G. Crit. Care Med. (2003) [Pubmed]
  16. Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against Fas-induced apoptosis. Hayashi, S., Miura, Y., Nishiyama, T., Mitani, M., Tateishi, K., Sakai, Y., Hashiramoto, A., Kurosaka, M., Shiozawa, S., Doita, M. Arthritis Rheum. (2007) [Pubmed]
  17. Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action. Yang, C.R., Hsieh, S.L., Teng, C.M., Ho, F.M., Su, W.L., Lin, W.W. Cancer Res. (2004) [Pubmed]
  18. Serum concentration of soluble decoy receptor 3 in glioma patients before and after surgery. Hwang, S.L., Lin, C.L., Cheng, C.Y., Lin, F.A., Lieu, A.S., Howng, S.L., Lee, K.S. The Kaohsiung journal of medical sciences. (2004) [Pubmed]
  19. In vivo inhibition of Fas ligand-mediated killing by TR6, a Fas ligand decoy receptor. Connolly, K., Cho, Y.H., Duan, R., Fikes, J., Gregorio, T., LaFleur, D.W., Okoye, Z., Salcedo, T.W., Santiago, G., Ullrich, S., Wei, P., Windle, K., Wong, E., Yao, X.T., Zhang, Y.Q., Zheng, G., Moore, P.A. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  20. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. Yu, K.Y., Kwon, B., Ni, J., Zhai, Y., Ebner, R., Kwon, B.S. J. Biol. Chem. (1999) [Pubmed]
  21. DcR3/TR6 effectively prevents islet primary nonfunction after transplantation. Wu, Y., Han, B., Luo, H., Roduit, R., Salcedo, T.W., Moore, P.A., Zhang, J., Wu, J. Diabetes (2003) [Pubmed]
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