Gene Review:
TNFRSF10D - tumor necrosis factor receptor superfamily...
Homo sapiens
Synonyms:
CD264, DCR2, DcR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, ...
- The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Meng, R.D., McDonald, E.R., Sheikh, M.S., Fornace, A.J., El-Deiry, W.S. Mol. Ther. (2000)
- Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand. Zhuang, L., Lee, C.S., Scolyer, R.A., McCarthy, S.W., Zhang, X.D., Thompson, J.F., Screaton, G., Hersey, P. Hum. Pathol. (2006)
- Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. Bouralexis, S., Findlay, D.M., Atkins, G.J., Labrinidis, A., Hay, S., Evdokiou, A. Br. J. Cancer (2003)
- Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation. van Noesel, M.M., van Bezouw, S., Salomons, G.S., Voûte, P.A., Pieters, R., Baylin, S.B., Herman, J.G., Versteeg, R. Cancer Res. (2002)
- The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells. Sun, S.Y., Yue, P., Chen, X., Hong, W.K., Lotan, R. Cancer Res. (2002)
- The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Degli-Esposti, M.A., Dougall, W.C., Smolak, P.J., Waugh, J.Y., Smith, C.A., Goodwin, R.G. Immunity (1997)
- TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections. Sträter, J., Walczak, H., Pukrop, T., Von Müller, L., Hasel, C., Kornmann, M., Mertens, T., Möller, P. Gastroenterology (2002)
- T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction. Colucci, S., Brunetti, G., Rizzi, R., Zonno, A., Mori, G., Colaianni, G., Del Prete, D., Faccio, R., Liso, A., Capalbo, S., Liso, V., Zallone, A., Grano, M. Blood (2004)
- A novel receptor for Apo2L/TRAIL contains a truncated death domain. Marsters, S.A., Sheridan, J.P., Pitti, R.M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A.D., Godowski, P., Ashkenazi, A. Curr. Biol. (1997)
- TNF-alpha-related apoptosis-inducing ligand decoy receptor DcR2 is targeted by androgen action in the rat ventral prostate. Vindrieux, D., Réveiller, M., Florin, A., Blanchard, C., Ruffion, A., Devonec, M., Benahmed, M., Grataroli, R. J. Cell. Physiol. (2006)
- Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types. Shivapurkar, N., Toyooka, S., Toyooka, K.O., Reddy, J., Miyajima, K., Suzuki, M., Shigematsu, H., Takahashi, T., Parikh, G., Pass, H.I., Chaudhary, P.M., Gazdar, A.F. Int. J. Cancer (2004)
- Decoy receptor-2 small interfering RNA (siRNA) strategy employing three different siRNA constructs in combination defeats adenovirus-transferred tumor necrosis factor-related apoptosis-inducing ligand resistance in lung cancer cells. Aydin, C., Sanlioglu, A.D., Karacay, B., Ozbilim, G., Dertsiz, L., Ozbudak, O., Akdis, C.A., Salih Sanlioglu, S. Hum. Gene Ther. (2007)
- TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege. Phillips, T.A., Ni, J., Pan, G., Ruben, S.M., Wei, Y.F., Pace, J.L., Hunt, J.S. J. Immunol. (1999)
- Control of apoptosis signaling by Apo2 ligand. Marsters, S.A., Pitti, R.A., Sheridan, J.P., Ashkenazi, A. Recent Prog. Horm. Res. (1999)
- Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis. Atkins, G.J., Bouralexis, S., Evdokiou, A., Hay, S., Labrinidis, A., Zannettino, A.C., Haynes, D.R., Findlay, D.M. Bone (2002)
- In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas. Hasel, C., Dürr, S., Rau, B., Sträter, J., Schmid, R.M., Walczak, H., Bachem, M.G., Möller, P. Lab. Invest. (2003)
- Low-dose UV-radiation sensitizes keratinocytes to TRAIL-induced apoptosis. Qin, J.Z., Bacon, P., Panella, J., Sitailo, L.A., Denning, M.F., Nickoloff, B.J. J. Cell. Physiol. (2004)
- TRAIL/Apo2L ligands induce apoptosis in malignant rhabdoid tumor cell lines. Yoshida, S., Narita, T., Koshida, S., Ohta, S., Takeuchi, Y. Pediatr. Res. (2003)
- Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2. Mérino, D., Lalaoui, N., Morizot, A., Schneider, P., Solary, E., Micheau, O. Mol. Cell. Biol. (2006)
- Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes. Leverkus, M., Neumann, M., Mengling, T., Rauch, C.T., Bröcker, E.B., Krammer, P.H., Walczak, H. Cancer Res. (2000)
- Clustering of hypermethylated genes in neuroblastoma. van Noesel, M.M., van Bezouw, S., Voûte, P.A., Herman, J.G., Pieters, R., Versteeg, R. Genes Chromosomes Cancer (2003)
- Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway. Kim, K.M., Lee, Y.J. Oncogene (2005)
- Potential for TRAIL as a therapeutic agent in ovarian cancer. Abdollahi, T. Vitam. Horm. (2004)
- Tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in human articular chondrocytes in vitro. Pettersen, I., Figenschau, Y., Olsen, E., Bakkelund, W., Smedsröd, B., Sveinbjörnsson, B. Biochem. Biophys. Res. Commun. (2002)
- Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer. Suzuki, M., Shigematsu, H., Shivapurkar, N., Reddy, J., Miyajima, K., Takahashi, T., Gazdar, A.F., Frenkel, E.P. Cancer Lett. (2006)