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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta.

In early pregnancy, placental trophoblast cells rapidly grow and invade into maternal uterine tissue. N-Acetylglucosaminyltransferase V (GnT-V) and its product, beta1-6-GlcNAc branching glycan, are known to correlate with tumor invasion and metastasis. Since the placentation process resembles invasion of cancer cells, we examined the expression of beta1-6-GlcNAc branching glycan and GnT-V in human placenta. Placentas derived from the first trimester contained a larger amount of beta1-6-GlcNAc branching glycan, detected by leukoagglutinating phytohemagglutinin lectin blotting, than those at term. Immunohistochemical study revealed that beta1-6-GlcNAc branching glycans and GnT-V protein were localized in the trophoblast layer. Both protein expression and the enzyme activity of GnT-V in first trimester placentas were higher than those at term. These results suggest that GnT-V would contribute to placentation in the early phase of pregnancy, possibly regulating the process of invasion of trophoblast cells.[1]


  1. Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta. Tomiie, M., Isaka, S., Miyoshi, E., Taniguchi, N., Kimura, T., Ogita, K., Tsutsui, T., Shimoya, K., Nakagawa, T., Kondo, A., Koyama, M., Murata, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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