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Yoshida, K. et al.

Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings.

BACKGROUND: Interferon (IFN)-alpha treatment frequently induces depression, which can impair quality of life and reduce treatment adherence. Defining relevant risk factors for IFN-alpha-induced depression is essential for designing preventative treatment strategies. OBJECTIVE: The purpose of the present study was to determine whether promoter polymorphisms of -408C/T, -3C/T and GT repeat dinucleotide microsatellite in the IFN-alpha/beta receptor 1 (IFNAR1) gene are associated with the development of IFN-induced depression. METHOD: Fifty patients with chronic hepatitis C were treated with pegylated IFN alpha-2b plus a standard or weight-based dose of ribavirin. Severity of depression was assessed using the Zung Self-Rating Depression Scale (SDS) at baseline and at 4, 8, 12 and 24 weeks of treatment. RESULT: The baseline to maximum difference in the SDS index score of neurovegetative/somatic symptoms was higher in patients with the 5/14 genotype of the GT repeat dinucleotide microsatellite polymorphism than in those patients with other genotypes (p = 0.0084). CONCLUSION: This preliminary result suggests that the promoter GT repeat dinucleotide microsatellite polymorphism of the IFNAR1 gene may represent a risk factor for the development of depressive symptoms during IFN-alpha therapy for hepatitis C and other conditions.[1]

References

Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings. Yoshida, K., Alagbe, O., Wang, X., Woolwine, B., Thornbury, M., Raison, C.L., Miller, A.H. Neuropsychobiology (2005) [Pubmed]

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