- DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice. Chang, Y., Yap, S., Ge, X., Piganelli, J., Bertera, S., Giannokakis, N., Mathews, C., Prud'homme, G., Trucco, M. Gene Ther. (2005)