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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Glycosylphosphatidylinositol-anchored fungal polysaccharide in Aspergillus fumigatus.

Galactomannan is a characteristic polysaccharide of the human filamentous fungal pathogen Aspergillus fumigatus that can be used to diagnose invasive aspergillosis. In this study, we report the isolation of a galactomannan fraction associated to membrane preparations from A. fumigatus mycelium by a lipid anchor. Specific chemical and enzymatic degradations and mass spectrometry analysis showed that the lipid anchor is a glycosylphosphatidylinositol (GPI). The lipid part is an inositol phosphoceramide containing mainly C18-phytosphingosine and monohydroxylated lignoceric acid (2OH-C(24:0) fatty acid). GPI glycan is a tetramannose structure linked to a glucosamine residue: Manalpha1-2Manalpha1-2Manalpha1-6Manalpha1-4GlcN. The galactomannan polymer is linked to the GPI structure through the mannan chain. The GPI structure is a type 1, closely related to the one previously described for the GPI-anchored proteins of A. fumigatus. This is the first time that a fungal polysaccharide is shown to be GPI-anchored.[1]


  1. Glycosylphosphatidylinositol-anchored fungal polysaccharide in Aspergillus fumigatus. Costachel, C., Coddeville, B., Latgé, J.P., Fontaine, T. J. Biol. Chem. (2005) [Pubmed]
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