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Chemical Compound Review

Galactomannan     (2R,3S,4R,5S,6R)-5- [(2S,3S,4S,5S,6R)-3,4,5...

Synonyms: AC1L975N, C00883, Galactomannoglycan
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Disease relevance of C00883


Psychiatry related information on C00883


High impact information on C00883

  • Glucuronoarabinoxylan, xyloglucan, and galactomannan are noncellulosic polysaccharides found in plant cell walls [7].
  • For T(1) generation individuals, transgene inheritance was correlated with galactomannan composition and amount in the endosperm [8].
  • The statistical distribution of galactosyl substituents along the mannan backbone, and the degree of galactose substitution of the primary product of galactomannan biosynthesis appear to be regulated by the specificity of the galactosyltransferase [9].
  • We have also confirmed the identity of the galactosyltransferase by inserting the cDNA in frame into the genome of the methylotrophic yeast Pichia pastoris under the control of an AOX promoter and the yeast alpha secretion factor and observing the secretion of galactomannan alpha-galactosyltransferase activity [9].
  • The kinetics of culture, polymerase chain reaction, and galactomannan were determined [10].

Chemical compound and disease context of C00883


Biological context of C00883


Anatomical context of C00883


Associations of C00883 with other chemical compounds


Gene context of C00883

  • We previously found that the disruption of gms1+, a gene encoding the UDP-galactose transporter required for the synthesis of galactomannan, led to the complete defect of cell surface galactosylation in Sz. pombe [27].
  • However two other mutants, cdc 4 and cdc 7, show a higher galactomannan content and a lower alpha-glucan content [28].
  • Detection of Aspergillus galactomannan by enzyme immunoabsorbent assay in recipients of allogeneic hematopoietic stem cell transplantation: a prospective study [29].
  • A radioaffinity assay for lectin binding to receptors was developed and characterized by using the interactions between soya-bean agglutinin and four glycoconjugates, namely thyroglobulin, galactomannan, fetuin and asialofetuin [30].
  • The higher sensitivity obtained by inhibition-EIA may well be due to its ability to detect circulating antigens other than GM in the sera of IC patients with IA [31].

Analytical, diagnostic and therapeutic context of C00883


  1. Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation. Maertens, J., Verhaegen, J., Lagrou, K., Van Eldere, J., Boogaerts, M. Blood (2001) [Pubmed]
  2. Prospective evaluation of a polymerase chain reaction-ELISA targeted to Aspergillus fumigatus and Aspergillus flavus for the early diagnosis of invasive aspergillosis in patients with hematological malignancies. Florent, M., Katsahian, S., Vekhoff, A., Levy, V., Rio, B., Marie, J.P., Bouvet, A., Cornet, M. J. Infect. Dis. (2006) [Pubmed]
  3. A non-modular endo-beta-1,4-mannanase from Pseudomonas fluorescens subspecies cellulosa. Braithwaite, K.L., Black, G.W., Hazlewood, G.P., Ali, B.R., Gilbert, H.J. Biochem. J. (1995) [Pubmed]
  4. Analysis of proteins associated with growth of Bacteroides ovatus on the branched galactomannan guar gum. Valentine, P.J., Salyers, A.A. Appl. Environ. Microbiol. (1992) [Pubmed]
  5. Discordant rise in galactomannan antigenemia in a patient with resolving Aspergillosis, renal failure, and ongoing hemodialysis. El Saleeby, C.M., Allison, K.J., Knapp, K.M., Walsh, T.J., Hayden, R.T. J. Clin. Microbiol. (2005) [Pubmed]
  6. Forum report: issues in the evaluation of diagnostic tests, use of historical controls, and merits of the current multicenter collaborative groups. Bennett, J.E., Kauffman, C., Walsh, T., de Pauw, B., Dismukes, W., Galgiani, J., Glauser, M., Herbrecht, R., Lee, J., Pappas, P., Powers, J., Rex, J., Verweij, P., Viscoli, C. Clin. Infect. Dis. (2003) [Pubmed]
  7. Expression of cellulose synthase-like (Csl) genes in insect cells reveals that CslA family members encode mannan synthases. Liepman, A.H., Wilkerson, C.G., Keegstra, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. The seeds of Lotus japonicus lines transformed with sense, antisense, and sense/antisense galactomannan galactosyltransferase constructs have structurally altered galactomannans in their endosperm cell walls. Edwards, M.E., Choo, T.S., Dickson, C.A., Scott, C., Gidley, M.J., Reid, J.S. Plant Physiol. (2004) [Pubmed]
  9. Molecular characterisation of a membrane-bound galactosyltransferase of plant cell wall matrix polysaccharide biosynthesis. Edwards, M.E., Dickson, C.A., Chengappa, S., Sidebottom, C., Gidley, M.J., Reid, J.S. Plant J. (1999) [Pubmed]
  10. Pathogenesis of Aspergillus fumigatus and the Kinetics of Galactomannan in an In Vitro Model of Early Invasive Pulmonary Aspergillosis: Implications for Antifungal Therapy. Hope, W.W., Kruhlak, M.J., Lyman, C.A., Petraitiene, R., Petraitis, V., Francesconi, A., Kasai, M., Mickiene, D., Sein, T., Peter, J., Kelaher, A.M., Hughes, J.E., Cotton, M.P., Cotten, C.J., Bacher, J., Tripathi, S., Bermudez, L., Maugel, T.K., Zerfas, P.M., Wingard, J.R., Drusano, G.L., Walsh, T.J. J. Infect. Dis. (2007) [Pubmed]
  11. Glycosylphosphatidylinositol-anchored fungal polysaccharide in Aspergillus fumigatus. Costachel, C., Coddeville, B., Latgé, J.P., Fontaine, T. J. Biol. Chem. (2005) [Pubmed]
  12. Efficacy of unilamellar liposomal amphotericin B in treatment of pulmonary aspergillosis in persistently granulocytopenic rabbits: the potential role of bronchoalveolar D-mannitol and serum galactomannan as markers of infection. Francis, P., Lee, J.W., Hoffman, A., Peter, J., Francesconi, A., Bacher, J., Shelhamer, J., Pizzo, P.A., Walsh, T.J. J. Infect. Dis. (1994) [Pubmed]
  13. Protective effect of lysozyme-galactomannan or lysozyme-palmitic acid conjugates against Edwardsiella tarda infection in carp, Cyprinus carpio L. Nakamura, S., Gohya, Y., Losso, J.N., Nakai, S., Kato, A. FEBS Lett. (1996) [Pubmed]
  14. Comparison of glucan detection and galactomannan enzyme immunoassay in gastrointestinal and systemic murine candidiasis. Nichterlein, T., Buchheidt, D., Hein, A., Becker, K.P., Mosbach, K., Kretschmar, M. Diagn. Microbiol. Infect. Dis. (2003) [Pubmed]
  15. Galactomannan hydrolysis and mannose metabolism in Cellvibrio mixtus. Centeno, M.S., Guerreiro, C.I., Dias, F.M., Morland, C., Tailford, L.E., Goyal, A., Prates, J.A., Ferreira, L.M., Caldeira, R.M., Mongodin, E.F., Nelson, K.E., Gilbert, H.J., Fontes, C.M. FEMS Microbiol. Lett. (2006) [Pubmed]
  16. alpha-Galactosidases II, III and IV from seeds of Trifolium repens. Purification, physicochemical properties and mode of galactomannan hydrolysis in vitro. Williams, J., Villarroya, H., Petek, F. Biochem. J. (1978) [Pubmed]
  17. Polymorphism of Sporothrix schenckii surface polysaccharides as a function of morphological differentiation. Mendonça, L., Gorin, P.A., Lloyd, K.O., Travassos, L.R. Biochemistry (1976) [Pubmed]
  18. Ingestion of yeast forms of Sporothrix schenckii by mouse peritoneal macrophages. Oda, L.M., Kubelka, C.F., Alviano, C.S., Travassos, L.R. Infect. Immun. (1983) [Pubmed]
  19. Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease. Dennis, C.G., Greco, W.R., Brun, Y., Youn, R., Slocum, H.K., Bernacki, R.J., Lewis, R., Wiederhold, N., Holland, S.M., Petraitiene, R., Walsh, T.J., Segal, B.H. Antimicrob. Agents Chemother. (2006) [Pubmed]
  20. Receptor-mediated clearance of Aspergillus galactomannan. Bennett, J.E., Friedman, M.M., Dupont, B. J. Infect. Dis. (1987) [Pubmed]
  21. Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis. Viscoli, C., Machetti, M., Gazzola, P., De Maria, A., Paola, D., Van Lint, M.T., Gualandi, F., Truini, M., Bacigalupo, A. J. Clin. Microbiol. (2002) [Pubmed]
  22. Towards designer cellulosomes in Clostridia: mannanase enrichment of the cellulosomes produced by Clostridium cellulolyticum. Perret, S., Bélaich, A., Fierobe, H.P., Bélaich, J.P., Tardif, C. J. Bacteriol. (2004) [Pubmed]
  23. Glycosidases induced in Aspergillus tamarii. Secreted alpha-D-galactosidase and beta-D-mannanase. Civas, A., Eberhard, R., Le Dizet, P., Petek, F. Biochem. J. (1984) [Pubmed]
  24. Chemical and immunological characterization of the extracellular galactomannan of Aspergillus fumigatus. Latgé, J.P., Kobayashi, H., Debeaupuis, J.P., Diaquin, M., Sarfati, J., Wieruszeski, J.M., Parra, E., Bouchara, J.P., Fournet, B. Infect. Immun. (1994) [Pubmed]
  25. Regulation of endo-acting glycosyl hydrolases in the hyperthermophilic bacterium Thermotoga maritima grown on glucan- and mannan-based polysaccharides. Chhabra, S.R., Shockley, K.R., Ward, D.E., Kelly, R.M. Appl. Environ. Microbiol. (2002) [Pubmed]
  26. Biochemical characterization of Thermotoga maritima endoglucanase Cel74 with and without a carbohydrate binding module (CBM). Chhabra, S.R., Kelly, R.M. FEBS Lett. (2002) [Pubmed]
  27. Characterization of a Schizosaccharomyces pombe mutant deficient in UDP-galactose transport activity. Tanaka, N., Konomi, M., Osumi, M., Takegawa, K. Yeast (2001) [Pubmed]
  28. Ultrastructure and cell wall composition in cell division cycle mutants of Schizosaccharomyces pombe deficient in septum formation. Mateos, P., Domínguez, A. Antonie Van Leeuwenhoek (1991) [Pubmed]
  29. Detection of Aspergillus galactomannan by enzyme immunoabsorbent assay in recipients of allogeneic hematopoietic stem cell transplantation: a prospective study. Rovira, M., Jimenéz, M., De La Bellacasa, J.P., Mensa, J., Rafel, M., Ortega, M., Almela, M., Martínez, C., Fernández-Avilés, F., Martínez, J.A., Urbano-Ispizua, A., Carreras, E., Montserrat, E. Transplantation (2004) [Pubmed]
  30. Interactions of soya-bean agglutinin with purified glycoconjugates and soya-bean seed components. Bond, H.M., Chaplin, M.F., Bowles, D.J. Biochem. J. (1985) [Pubmed]
  31. Aspergillus Fumigatus antigen detection in sera from patients at risk for invasive aspergillosis. Chumpitazi, B.F., Pinel, C., Lebeau, B., Ambroise-Thomas, P., Grillot, R. J. Clin. Microbiol. (2000) [Pubmed]
  32. Aspergillus galactomannan detection in the diagnosis of invasive aspergillosis in cancer patients. Herbrecht, R., Letscher-Bru, V., Oprea, C., Lioure, B., Waller, J., Campos, F., Villard, O., Liu, K.L., Natarajan-Amé, S., Lutz, P., Dufour, P., Bergerat, J.P., Candolfi, E. J. Clin. Oncol. (2002) [Pubmed]
  33. Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance. Marr, K.A., Balajee, S.A., McLaughlin, L., Tabouret, M., Bentsen, C., Walsh, T.J. J. Infect. Dis. (2004) [Pubmed]
  34. Aspergillus antigenemia sandwich-enzyme immunoassay test as a serodiagnostic method for invasive aspergillosis in liver transplant recipients. Fortun, J., Martin-Davila, P., Alvarez, M.E., Sanchez-Sousa, A., Quereda, C., Navas, E., Barcena, R., Vicente, E., Candelas, A., Honrubia, A., Nuño, J., Pintado, V., Moreno, S. Transplantation (2001) [Pubmed]
  35. Galactomannan antigenemia and antigenuria in aspergillosis: studies in patients and experimentally infected rabbits. Dupont, B., Huber, M., Kim, S.J., Bennett, J.E. J. Infect. Dis. (1987) [Pubmed]
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