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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Aspergillosis


Psychiatry related information on Aspergillosis


High impact information on Aspergillosis


Chemical compound and disease context of Aspergillosis


Biological context of Aspergillosis


Anatomical context of Aspergillosis


Gene context of Aspergillosis

  • Unusual clinical features including a severe outcome in childhood, with a lethal outcome at age 22, and biliary aspergillosis were recorded in patients with a CFTR mutation.CONCLUSIONS: The proportion of CF carriers is not significantly higher in PSC patients than in the general population [26].
  • Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis [27].
  • Our findings indicate that serum PTX3 was elevated in only 1/11 afebrile episodes, despite evidence of mucositis (median 1.39), in 10/10 episodes of blood stream or target organ infections (median 7.2) but, surprisingly, was normal in 5/5 episodes of invasive aspergillosis (median 1.39) [28].
  • Therapeutic administration of SP-D and MBL proteins in a murine model of pulmonary invasive aspergillosis rescued mice from death [29].
  • TNF, a recognition cytokine, has been shown to be required for initiation of the innate response in the mouse model of invasive aspergillosis [30].

Analytical, diagnostic and therapeutic context of Aspergillosis


  1. Amphotericin B nasal spray as prophylaxis against aspergillosis in patients with neutropenia. Meunier-Carpentier, F., Snoeck, R., Gerain, J., Muller, C., Klastersky, J. N. Engl. J. Med. (1984) [Pubmed]
  2. A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas. Enblad, G., Hagberg, H., Erlanson, M., Lundin, J., MacDonald, A.P., Repp, R., Schetelig, J., Seipelt, G., Osterborg, A. Blood (2004) [Pubmed]
  3. Analysis of compassionate use itraconazole therapy for invasive aspergillosis by the NIAID Mycoses Study Group criteria. Stevens, D.A., Lee, J.Y. Arch. Intern. Med. (1997) [Pubmed]
  4. Invasive aspergillosis in a patient with ticlopidine-induced agranulocytosis. Rimbrot, S., Kundzinsh, E., Levy, Y. Arch. Intern. Med. (2000) [Pubmed]
  5. Invasive aspergillosis complicating Cushing's syndrome. Walsh, T.J., Mendelsohn, G. Arch. Intern. Med. (1981) [Pubmed]
  6. Renal invasive aspergilloma: unusual infection in AIDS. Fiteni, I., Crusells, M.J., Cuesta, J., Letona, S. J. Infect. (1996) [Pubmed]
  7. Invasive pulmonary aspergillosis associated with high-dose inhaled fluticasone. Leav, B.A., Fanburg, B., Hadley, S. N. Engl. J. Med. (2000) [Pubmed]
  8. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Garlanda, C., Hirsch, E., Bozza, S., Salustri, A., De Acetis, M., Nota, R., Maccagno, A., Riva, F., Bottazzi, B., Peri, G., Doni, A., Vago, L., Botto, M., De Santis, R., Carminati, P., Siracusa, G., Altruda, F., Vecchi, A., Romani, L., Mantovani, A. Nature (2002) [Pubmed]
  9. Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis. Morrison, B.E., Park, S.J., Mooney, J.M., Mehrad, B. J. Clin. Invest. (2003) [Pubmed]
  10. Aspergillus antigen latex test for diagnosis of invasive aspergillosis. Knight, F., Mackenzie, D.W. Lancet (1992) [Pubmed]
  11. Disseminated aspergillosis in high dose steroid therapy. Williams, A.J., Zardawi, I., Walls, J. Lancet (1983) [Pubmed]
  12. Infectious complications in heart transplant recipients receiving cyclosporine and corticosteroids. Hofflin, J.M., Potasman, I., Baldwin, J.C., Oyer, P.E., Stinson, E.B., Remington, J.S. Ann. Intern. Med. (1987) [Pubmed]
  13. Invasive aspergillosis in acute leukemia: correlation with nose cultures and antibiotic use. Aisner, J., Murillo, J., Schimpff, S.C., Steere, A.C. Ann. Intern. Med. (1979) [Pubmed]
  14. Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Gerson, S.L., Talbot, G.H., Hurwitz, S., Strom, B.L., Lusk, E.J., Cassileth, P.A. Ann. Intern. Med. (1984) [Pubmed]
  15. Improved outcome in central nervous system aspergillosis, using voriconazole treatment. Schwartz, S., Ruhnke, M., Ribaud, P., Corey, L., Driscoll, T., Cornely, O.A., Schuler, U., Lutsar, I., Troke, P., Thiel, E. Blood (2005) [Pubmed]
  16. Aspergillus galactomannan detection in the diagnosis of invasive aspergillosis in cancer patients. Herbrecht, R., Letscher-Bru, V., Oprea, C., Lioure, B., Waller, J., Campos, F., Villard, O., Liu, K.L., Natarajan-Amé, S., Lutz, P., Dufour, P., Bergerat, J.P., Candolfi, E. J. Clin. Oncol. (2002) [Pubmed]
  17. Cerebral aspergillosis in a liver transplant recipient: a case report of long-term survival after combined treatment with liposomal amphotericin B and surgery. Iemmolo, R.M., Rossanese, A., Rotilio, A., Mattisi, G., Gerunda, G.E., Merenda, R., Neri, D., Crepaldi, G., Strazzabosco, M. J. Hepatol. (1998) [Pubmed]
  18. Efficacy, safety, and plasma pharmacokinetics of escalating dosages of intravenously administered ravuconazole lysine phosphoester for treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits. Petraitiene, R., Petraitis, V., Lyman, C.A., Groll, A.H., Mickiene, D., Peter, J., Bacher, J., Roussillon, K., Hemmings, M., Armstrong, D., Avila, N.A., Walsh, T.J. Antimicrob. Agents Chemother. (2004) [Pubmed]
  19. Effect of granulocyte colony-stimulating factor combination therapy on efficacy of posaconazole (SCH56592) in an inhalation model of murine pulmonary aspergillosis. Patera, A.C., Menzel, F., Jackson, C., Brieland, J.K., Halpern, J., Hare, R., Cacciapuoti, A., Loebenberg, D. Antimicrob. Agents Chemother. (2004) [Pubmed]
  20. Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosis. Becker, M.J., de Marie, S., Fens, M.H., Verbrugh, H.A., Bakker-Woudenberg, I.A. J. Antimicrob. Chemother. (2003) [Pubmed]
  21. Effect of elimination of phagocytic cells by liposomal dichloromethylene diphosphonate on aspergillosis virulence and toxicity of liposomal amphotericin B in mice. Moonis, M., Ahmad, I., Bachhawat, B.K. J. Antimicrob. Chemother. (1994) [Pubmed]
  22. Th1 and Th2 cytokines in mice with invasive aspergillosis. Cenci, E., Perito, S., Enssle, K.H., Mosci, P., Latgé, J.P., Romani, L., Bistoni, F. Infect. Immun. (1997) [Pubmed]
  23. Successful treatment of subcutaneously disseminated aspergillosis with caspofungin acetate in an allogeneic peripheral blood stem cell transplantation patient. Chamuleau, M.E., Deenik, W., Zweegman, S., Jonkhoff, A.R., Zaaijer, H.L., Janssen, J.J. Haematologica (2003) [Pubmed]
  24. Progressive disseminated aspergillosis in a bone marrow transplant recipient: response with a high-dose lipid formulation of amphotericin B. Kontoyiannis, D.P., Andersson, B.S., Lewis, R.E., Raad, I.I. Clin. Infect. Dis. (2001) [Pubmed]
  25. Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis. Viscoli, C., Machetti, M., Gazzola, P., De Maria, A., Paola, D., Van Lint, M.T., Gualandi, F., Truini, M., Bacigalupo, A. J. Clin. Microbiol. (2002) [Pubmed]
  26. Cystic fibrosis transmembrane conductance regulator (CFTR) gene defects in patients with primary sclerosing cholangitis. Girodon, E., Sternberg, D., Chazouillères, O., Cazeneuve, C., Huot, D., Calmus, Y., Poupon, R., Goossens, M., Housset, C. J. Hepatol. (2002) [Pubmed]
  27. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Balloy, V., Si-Tahar, M., Takeuchi, O., Philippe, B., Nahori, M.A., Tanguy, M., Huerre, M., Akira, S., Latgé, J.P., Chignard, M. Infect. Immun. (2005) [Pubmed]
  28. Selective induction of pentraxin 3, a soluble innate immune pattern recognition receptor, in infectious episodes in patients with haematological malignancy. al-Ramadi, B.K., Ellis, M., Pasqualini, F., Mantovani, A. Clin. Immunol. (2004) [Pubmed]
  29. Role of collectins in innate immunity against aspergillosis. Madan, T., Kaur, S., Saxena, S., Singh, M., Kishore, U., Thiel, S., Reid, K.B., Sarma, P.U. Med. Mycol. (2005) [Pubmed]
  30. Cytokines in host defense against Aspergillus: recent advances. Phadke, A.P., Mehrad, B. Med. Mycol. (2005) [Pubmed]
  31. Low-dose amphotericin B prophylaxis against invasive Aspergillus infections in allogeneic marrow transplantation. Rousey, S.R., Russler, S., Gottlieb, M., Ash, R.C. Am. J. Med. (1991) [Pubmed]
  32. Intranasal amphotericin B reduces the frequency of invasive aspergillosis in neutropenic patients. Jeffery, G.M., Beard, M.E., Ikram, R.B., Chua, J., Allen, J.R., Heaton, D.C., Hart, D.N., Schousboe, M.I. Am. J. Med. (1991) [Pubmed]
  33. Current approaches to diagnosis and treatment of invasive aspergillosis. Segal, B.H., Walsh, T.J. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  34. Ultrastructural demonstration of specific IgG and IgE antibodies binding to Aspergillus fumigatus from patients with aspergillosis. Reijula, K.E., Kurup, V.P., Fink, J.N. J. Allergy Clin. Immunol. (1991) [Pubmed]
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