Disease relevance of Aspergillosis

• Amphotericin B nasal spray as prophylaxis against aspergillosis in patients with neutropenia [1].
• Toxicity included cytomegalovirus reactivation in 6 patients, which was successfully treated with ganciclovir or foscarnet; pulmonary aspergillosis in 2 patients; and pancytopenia in 4 patients [2].
• Analysis of compassionate use itraconazole therapy for invasive aspergillosis by the NIAID Mycoses Study Group criteria [3].
• Invasive aspergillosis in a patient with ticlopidine-induced agranulocytosis [4].
• Two patients with Cushing's syndrome and notably elevated levels of circulating cortisol had invasive aspergillosis develop [5].

Psychiatry related information on Aspergillosis

• He had heroin addiction, AIDS in advanced stage C3, neutropenia and received antifungal prophyllaxis as predisposing factors to aspergillosis [6].

High impact information on Aspergillosis

• Invasive pulmonary aspergillosis associated with high-dose inhaled fluticasone [7].
• Ptx3-null mice were susceptible to invasive pulmonary aspergillosis [8].
• We found a rapid and marked induction of MCP-1/CCL2 in the lungs of neutropenic mice with invasive aspergillosis [9].
• Aspergillus antigen latex test for diagnosis of invasive aspergillosis [10].
• Disseminated aspergillosis in high dose steroid therapy [11].

Chemical compound and disease context of Aspergillosis

• The frequency of aspergillosis was decreased by 54% in the cyclosporine-treated group, but half of these infections disseminated beyond the lung and such dissemination was always fatal [12].
• Carbenicillin was used for a longer period among cases and patients with predictive nose cultures than among patients without aspergillosis [13].
• Cases and controls received similar chemotherapeutic regimens, and exposure to aminoglycosides, carbenicillin, trimethoprim-sulfamethoxazole, or corticosteroids was not significantly associated with development of invasive pulmonary aspergillosis [14].
• We evaluated, retrospectively, the outcome and survival of 81 patients who were treated with voriconazole for definite (n = 48) or probable (n = 33) CNS aspergillosis [15].
• Aspergillus galactomannan detection in the diagnosis of invasive aspergillosis in cancer patients [16].

Biological context of Aspergillosis

• This first report of long-term complication-free survival in a liver transplant recipient suggests that therapy with liposomal amphotericin B may reduce the risk of recurrence of cerebral aspergillosis in these immunocompromised patients [17].
• Efficacy, safety, and plasma pharmacokinetics of escalating dosages of intravenously administered ravuconazole lysine phosphoester for treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits [18].
• Effect of granulocyte colony-stimulating factor combination therapy on efficacy of posaconazole (SCH56592) in an inhalation model of murine pulmonary aspergillosis [19].
• Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosis [20].
• Effect of elimination of phagocytic cells by liposomal dichloromethylene diphosphonate on aspergillosis virulence and toxicity of liposomal amphotericin B in mice [21].

Anatomical context of Aspergillosis

• Improved outcome in central nervous system aspergillosis, using voriconazole treatment [15].
• With a murine model of invasive aspergillosis we investigated cytokine production by CD4+ T helper cells and the effects of cytokine administration or neutralization on the course and outcome of infection [22].
• Disseminated aspergillosis after stem cell transplantation has a high mortality despite treatment with amphotericin B or one of the azoles [23].
• Progressive disseminated aspergillosis in a bone marrow transplant recipient: response with a high-dose lipid formulation of amphotericin B [24].
• Cerebrospinal fluid galactomannan levels were significantly higher in aspergillosis patients, and most galactomannan was produced intrathecally [25].

Gene context of Aspergillosis

• Unusual clinical features including a severe outcome in childhood, with a lethal outcome at age 22, and biliary aspergillosis were recorded in patients with a CFTR mutation.CONCLUSIONS: The proportion of CF carriers is not significantly higher in PSC patients than in the general population [26].
• Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis [27].
• Our findings indicate that serum PTX3 was elevated in only 1/11 afebrile episodes, despite evidence of mucositis (median 1.39), in 10/10 episodes of blood stream or target organ infections (median 7.2) but, surprisingly, was normal in 5/5 episodes of invasive aspergillosis (median 1.39) [28].
• Therapeutic administration of SP-D and MBL proteins in a murine model of pulmonary invasive aspergillosis rescued mice from death [29].
• TNF, a recognition cytokine, has been shown to be required for initiation of the innate response in the mouse model of invasive aspergillosis [30].

Analytical, diagnostic and therapeutic context of Aspergillosis

• CONCLUSION: These data suggest that the risks of invasive aspergillosis in allogeneic marrow transplant recipients can be reduced by administration of prophylactic amphotericin B during the pretransplant and peritransplant periods [31].
• CONCLUSION: Intranasal aerosolized amphotericin B may protect against invasive aspergillosis, even when neutropenic patients are cared for in conventional wards without HEPA filtration [32].
• RESULTS: There was a significant reduction in both the incidence (p = 0.003) and mortality (p = 0.03) of invasive aspergillosis in patients receiving amphotericin B chemoprophylaxis as compared with those not receiving chemoprophylaxis [31].
• Chest computed tomography scans and new non-culture-based assays such as antigen detection and polymerase chain reaction may facilitate the early diagnosis of invasive aspergillosis, but have limitations [33].
• This method therefore demonstrates localization of antigens binding to different isotypes in the sera from different clinical forms of aspergillosis and may be useful in purifying specific antigens for immunodiagnosis [34].

References