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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion.

AIM: To investigate the neuroprotective effect and mechanisms of scutellarin, a flavonoid extracted from Erigeron breviscapus Hand Mazz, against neuronal damage following cerebral ischemia/reperfusion. METHODS: Rats were pretreated ig with scutellarin for 7 d and then subjected to cerebral ischemia/reperfusion (I/R) injury induced by a middle cerebral artery occlusion (MCAO). The infarct volume and neurological deficit were determined by TTC staining and Longa's score. The permeability of the blood-brain barrier was evaluated by measurement of the Evans blue (EB) content in the brain with a spectrophotometer. The total NOx content was determined. Nitric oxide synthase (NOS) isoforms ( iNOS, eNOS, nNOS) and the key angiogenic molecules, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor ( bFGF), were detected by Western blotting. RESULTS: Scutellarin significantly reduced infarct volume (P<0.05 or P<0.01), ameliorated the neurological deficit and reduced the permeability of the blood-brain barrier (BBB) (P<0.05). When rats were pretreated with scutellarin (50 or 75 mg/kg), upregulation of eNOS expression and downregulation of VEGF, bFGF, and iNOS expression was observed, whereas scutellarin had no effect on nNOS expression. CONCLUSION: Scutellarin has protective effects for cerebral injury through regulating the expression of NOS isoforms and angiogenic molecules.[1]


  1. Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion. Hu, X.M., Zhou, M.M., Hu, X.M., Zeng, F.D. Acta Pharmacol. Sin. (2005) [Pubmed]
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