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Savaraj, N. et al.

Savaraj, Wu, Landy, Wangpaijit, Wei, Kuo, Robles, Furst, Lampidis, Feun,

Procollagen alpha 1 type 1: a potential aide in histopathological grading of glioma.

Collagen type I production has been shown to play a role in malignant transformation. We examined procollagen type I expression in brain tumors and with histopathological grading. Expression levels of procollagen alpha 1 type 1 were determined in 5 glioma cell lines by RT-PCR, Northern, and Western blot analysis. In addition, 41 primary brain tumors and 2 metastatic lung cancers to the brain were examined by PCR. Of the 5 glioma cell line analyzed, 3 (glioma 1, SW-1783 and U-118) expressed procollagen alpha 1 type I and were sensitive to vitamin D3 (VD3). In contrast, 2 of the cell lines (U-373 and T-98G) lacked procollagen alpha 1 type 1 expression. In patients' samples, 14 of 15 anaplastic and low grade gliomas expressed procollagen alpha 1 type I, and 12 of the 14 expressed high levels. In contrast, only 12 of 21 high grade gliomas from patients expressed procollagen alpha 1 type1 and among these, only 4 of the 12 expressed high levels. Thus, there is an inversed correlation between procollagen alpha 1 type 1 expression and histopathological grading (R2=- 0.56, p=0.0005). Our data suggest that procollagen alpha 1 type I expression occurs more commonly in intermediate and low grade gliomas and may assist in histopathological grading.[1]

References

Procollagen alpha 1 type 1: a potential aide in histopathological grading of glioma. Savaraj, N., Wu, C., Landy, H., Wangpaijit, M., Wei, Y., Kuo, M.T., Robles, C., Furst, A.J., Lampidis, T., Feun, L. Cancer Invest. (2005) [Pubmed]

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