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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Schuchmann, M. et al.

Schuchmann, Ruckert, Garcia-Lazaro, Karg, Burg, Knorr, Siebler, Varfolomeev, Wallach, Schreiber, Lohse, Galle,

MORT1/FADD is involved in liver regeneration.

AIM:To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining. RESULTS: Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A expression was only detectable in wild-type animals. Consequently, the onset of liver mass restoration was retarded as measured by MRI volumetry and mortality was significantly higher in the transgenic group. CONCLUSION: Our data demonstrate for the first time an involvement of the death receptor molecule MORT1/FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.[1]

References

MORT1/FADD is involved in liver regeneration. Schuchmann, M., Ruckert, F., Garcia-Lazaro, J.F., Karg, A., Burg, J., Knorr, N., Siebler, J., Varfolomeev, E.E., Wallach, D., Schreiber, W., Lohse, A.W., Galle, P.R. World J. Gastroenterol. (2005) [Pubmed]

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