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Itoh, K. et al.

Itoh, Sawasaki, Takeuchi, Kato, Imai, Kato, Shibata, Kobayashi, Moriguchi, Higuchi, Ishihata, Sudoh, Miura,

Erythropoietin-induced proliferation of gastric mucosal cells.

AIM: To analyze the localization of erythropoietin receptor on gastric specimens and characterize the effects of erythropoietin on the normal gastric epithelial proliferation using a porcine gastric epithelial cell culture model. METHODS: Erythropoietin receptor was detected by RT-PCR, Western blotting and immunohistochermistry. Growth stimulation effects of erythropoietin on cultured gastric mucosal cells were determined by ELISA using bromodeoxyuridine (BrdU). RESULTS: Erythropoietin receptor was detected on cultured porcine gastric mucosal epithelial cells. Erythropoietin receptor was also detected histochemically at the base of gastric mucosal epithelium. BrdU assay demonstrated a dose-dependent increase in growth potential of cultured porcine gastric mucosal epithelial cells by administration of erythropoietin, as well as these effects were inhibited by administration of anti- erythropoietin antibody (P<0.01). CONCLUSION: These findings indicate that erythropoietin has a potential to proliferate gastric mucosal epithelium via erythropoietin receptor.[1]

References

Erythropoietin-induced proliferation of gastric mucosal cells. Itoh, K., Sawasaki, Y., Takeuchi, K., Kato, S., Imai, N., Kato, Y., Shibata, N., Kobayashi, M., Moriguchi, Y., Higuchi, M., Ishihata, F., Sudoh, Y., Miura, S. World J. Gastroenterol. (2006) [Pubmed]

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