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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The thyroid endocrine disruptor perchlorate affects reproduction, growth, and survival of mosquitofish.

The perchlorate anion--an oxidizer found in rockets, missiles, some ammunition, flares, airbags, and fireworks--occurs as a contaminant in ground and surface water in many parts of the United States. Its toxic effects include inhibition of thyroid hormone synthesis. To investigate its chronic toxicity, mosquitofish (Gambusia holbrooki) adults and fry were exposed to aqueous sodium perchlorate at 1, 10, and 100mg/L, and growth and reproductive performance (fecundity, eggs/embryos mass, and gonadosomatic index [GSI]) were determined. Five-day acute toxicity tests were also performed. Perchlorate had a stimulatory effect on fecundity, GSI, and egg/embryo mass, at least for some treatments. The LC50 of sodium perchlorate was 404 mg/L. Growth was enhanced at 1mg/L but inhibited at 10mg/L. These results suggest that, at environmentally relevant concentrations, perchlorate does not induce acutely toxic effects but may have mild stimulatory or hormetic effects on fitness parameters in this species.[1]


  1. The thyroid endocrine disruptor perchlorate affects reproduction, growth, and survival of mosquitofish. Park, J.W., Rinchard, J., Liu, F., Anderson, T.A., Kendall, R.J., Theodorakis, C.W. Ecotoxicol. Environ. Saf. (2006) [Pubmed]
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