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Disease relevance of Cyprinodontiformes


High impact information on Cyprinodontiformes

  • Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus [4].
  • Electrophoretic variations ascribable to three enzyme loci coding for esterase-1 and -4 (ES1 and ES4) and a malate dehydrogenase-2 isozyme (MDH2) were studied in interspecific backcrosses of fishes of the genus Xiphophorus (Poeciliidae) [5].
  • Fluence response relationships for the induction of DNA damage in the skin of UV-irradiated Xiphophorus fish were obtained by quantitative gel electrophoresis of unlabeled DNA following extraction and treatment with an enzyme preparation that makes single strand breaks next to cyclobutane pyrimidine dimers [6].
  • Our findings may indicate that c-src activity in Xiphophorus is modulated by the Tu gene product or that Tu and c-src are regulated coordinately [7].
  • We have cloned, sequenced, and characterized the RNA expression properties of a fish CDKN2 gene from Xiphophorus helleri and X. maculatus [8].

Chemical compound and disease context of Cyprinodontiformes


Biological context of Cyprinodontiformes


Anatomical context of Cyprinodontiformes


Associations of Cyprinodontiformes with chemical compounds

  • Certain populations of mosquitofish (Gambusia affinis) are highly resistant to endrin (42-fold), but are not cross-resistant to cypermethrin [24].
  • Male mosquitofish (Gambusia holbrooki) were collected monthly from December 2000 through May 2001 from Lake Apopka and two nearby reference lakes, Orange Lake and Lake Woodruff National Wildlife Refuge [25].
  • Estrogen target cells in the pituitary of platyfish, Xiphophorus maculatus [26].
  • This report focuses on the impact of low concentrations of two purported endocrine-disrupting xenobiotic compounds, nonylphenol and methoxychlor, on two freshwater teleosts of the genus Xiphophorus, X. maculatus, commonly known as the platyfish, and X. helleri, commonly known as the swordtail [27].
  • The blood androgen and glucocorticoid levels of male Haplochromis burtoni and Xiphophorus helleri were measured in socially isolated individuals (8 and 4 weeks, respectively) and nonisolated controls [28].

Gene context of Cyprinodontiformes

  • Previously we assigned the Xiphophorus homologue of the human ERCC2 gene to linkage group U5 in tight association with the CKM locus [29].
  • Specific activation of a STAT family member in Xiphophorus melanoma cells [30].
  • To study their structural and functional conservation during evolution, we have compared NGF and BDNF from a lower vertebrate, the teleost fish Xiphophorus, with the mammalian homologues [31].
  • The cumulative evidence indicates that in Xiphophorus, Xmrk suppresses differentiation signals relayed by MITF as part of the transformation process finally resulting in melanoma formation [32].
  • Assignment of the TP53 orthologue to a new linkage group (LG XIV) in fish of the genus Xiphophorus (Teleostei: Poeciliidae) [33].

Analytical, diagnostic and therapeutic context of Cyprinodontiformes


  1. The Xmrk oncogene promoter is derived from a novel amplified locus of unusual organization. Förnzler, D., Altschmied, J., Nanda, I., Kolb, R., Baudler, M., Schmid, M., Schartl, M. Genome Res. (1996) [Pubmed]
  2. The thyroid endocrine disruptor perchlorate affects reproduction, growth, and survival of mosquitofish. Park, J.W., Rinchard, J., Liu, F., Anderson, T.A., Kendall, R.J., Theodorakis, C.W. Ecotoxicol. Environ. Saf. (2006) [Pubmed]
  3. Genetics of susceptibility in the platyfish/swordtail tumor system to develop fibrosarcoma and rhabdomyosarcoma following treatment with N-methyl-N-nitrosourea (MNU). Schwab, M., Abdo, S., Ahuja, M.R., Kollinger, G., Anders, A., Anders, F., Frese, K. Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology. (1978) [Pubmed]
  4. Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Wittbrodt, J., Adam, D., Malitschek, B., Mäueler, W., Raulf, F., Telling, A., Robertson, S.M., Schartl, M. Nature (1989) [Pubmed]
  5. Linkage group V of platyfishes and Swordtails of the genus Xiphophorus (Poeciliidae): linkage of loci for malate dehydrogenase-2 and esterase-1 and esterase-4 with a gene controlling the severity of hybrid melanomas. Morizot, D.C., Siciliano, M.J. J. Natl. Cancer Inst. (1983) [Pubmed]
  6. Ultraviolet radiation-induced DNA damage and its photorepair in the skin of the platyfish Xiphophorus. Ahmed, F.E., Setlow, R.B. Cancer Res. (1993) [Pubmed]
  7. Correlations of inheritance and expression between a tumor gene and the cellular homolog of the Rous sarcoma virus-transforming gene in Xiphophorus. Schartl, M., Barnekow, A., Bauer, H., Anders, F. Cancer Res. (1982) [Pubmed]
  8. Comparative structure and characterization of a CDKN2 gene in a Xiphophorus fish melanoma model. Kazianis, S., Morizot, D.C., Coletta, L.D., Johnston, D.A., Woolcock, B., Vielkind, J.R., Nairn, R.S. Oncogene (1999) [Pubmed]
  9. Virus-like particles induced by bromodeoxyuridine in melanoma and neuroblastoma of Xiphophorus. Kollinger, G., Schwab, M., Anders, F. J. Cancer Res. Clin. Oncol. (1979) [Pubmed]
  10. In vivo evaluation of three biomarkers in the mosquitofish (Gambusia yucatana) exposed to pesticides. Rendón-von Osten, J., Ortíz-Arana, A., Guilhermino, L., Soares, A.M. Chemosphere (2005) [Pubmed]
  11. A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides. De Rosa, S., Crispino, A., De Giulio, A., Iodice, C., Benrezzouk, R., Terencio, M.C., Ferrándiz, M.L., Alcaraz, M.J., Payá, M. J. Nat. Prod. (1998) [Pubmed]
  12. Acute toxicity of widely used pharmaceuticals in aquatic species: Gambusia holbrooki, Artemia parthenogenetica and Tetraselmis chuii. Nunes, B., Carvalho, F., Guilhermino, L. Ecotoxicol. Environ. Saf. (2005) [Pubmed]
  13. Laboratory evaluation of dimilin on growth and glutathione activity in mosquitofish, a non-target species. Draredja-Beldi, H., Soltani, N. Communications in agricultural and applied biological sciences. (2003) [Pubmed]
  14. Jule from the fish Xiphophorus is the first complete vertebrate Ty3/Gypsy retrotransposon from the Mag family. Volff, J.N., Körting, C., Altschmied, J., Duschl, J., Sweeney, K., Wichert, K., Froschauer, A., Schartl, M. Mol. Biol. Evol. (2001) [Pubmed]
  15. Immunocytochemical changes in serotonin in the forebrain and pituitary of aging fish. Margolis-Nunno, H., Halpern-Sebold, L., Schreibman, M.P. Neurobiol. Aging (1986) [Pubmed]
  16. Identification and mapping of two divergent, unlinked major histocompatibility complex class II B genes in Xiphophorus fishes. McConnell, T.J., Godwin, U.B., Norton, S.F., Nairn, R.S., Kazianis, S., Morizot, D.C. Genetics (1998) [Pubmed]
  17. Construction and initial analysis of bacterial artificial chromosome (BAC) contigs from the sex-determining region of the platyfish Xiphophorus maculatus. Froschauer, A., Körting, C., Katagiri, T., Aoki, T., Asakawa, S., Shimizu, N., Schartl, M., Volff, J.N. Gene (2002) [Pubmed]
  18. Triplet repeat variability in the signal peptide sequence of the Xmrk receptor tyrosine kinase gene in Xiphophorus fish. Schartl, M., Wilde, B., Hornung, U. Gene (1998) [Pubmed]
  19. Immunoreactive tyrosine hydroxylase in the brain and pituitary gland of the platyfish. Halpern-Sebold, L.R., Margolis-Kazan, H., Schreibman, M.P., Joh, T.H. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  20. Effects of nonylphenol and 17beta-estradiol on vitellogenin synthesis and testis morphology in male platyfish Xiphophorus maculatus. Kinnberg, K., Korsgaard, B., Bjerregaard, P., Jespersen, A. J. Exp. Biol. (2000) [Pubmed]
  21. Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations. Bradford, C.M., Rinchard, J., Carr, J.A., Theodorakis, C. Environ. Sci. Technol. (2005) [Pubmed]
  22. Topographical distribution of estrogen target cells in the forebrain of platyfish, Xiphophorus maculatus, studied by autoradiography. Kim, Y.S., Stumpf, W.E., Sar, M. Brain Res. (1979) [Pubmed]
  23. Use of immunocytochemical staining of somatostatin for correlative light and electron microscopic investigation of D cells in the pancreatic islet of Xiphophorus helleri H. (Teleostei). Klein, C., Van Noorden, S. Cell Tissue Res. (1978) [Pubmed]
  24. Role of the brain t-butylbicyclophosphorothionate receptor in vertebrate resistance to endrin, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane and cypermethrin. Bonner, J.C., Yarbrough, J.D. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  25. Disturbed sexual characteristics in male mosquitofish (Gambusia holbrooki) from a lake contaminated with endocrine disruptors. Toft, G., Edwards, T.M., Baatrup, E., Guillette, L.J. Environ. Health Perspect. (2003) [Pubmed]
  26. Estrogen target cells in the pituitary of platyfish, Xiphophorus maculatus. Kim, Y.S., Sar, M., Stumpf, W.E. Cell Tissue Res. (1979) [Pubmed]
  27. Endocrine disruption caused by two common pollutants at "acceptable" concentrations. Magliulo, L., Schreibman, M.P., Cepriano, J., Ling, J. Neurotoxicology and teratology. (2002) [Pubmed]
  28. The effect of social isolation on androgen and corticosteroid levels in a cichlid fish (Haplochromis burtoni) and in swordtails (Xiphophorus helleri). Hannes, R.P., Franck, D. Hormones and behavior. (1983) [Pubmed]
  29. Cloning and gene map assignment of the Xiphophorus DNA ligase 1 gene. Walter, R.B., Rolig, R.L., Kozak, K.A., McEntire, B., Morizot, D.C., Nairn, R.S. Mol. Biol. Evol. (1993) [Pubmed]
  30. Specific activation of a STAT family member in Xiphophorus melanoma cells. Baudler, M., Schartl, M., Altschmied, J. Exp. Cell Res. (1999) [Pubmed]
  31. Brain-derived neurotrophic factor is more highly conserved in structure and function than nerve growth factor during vertebrate evolution. Götz, R., Raulf, F., Schartl, M. J. Neurochem. (1992) [Pubmed]
  32. MITF-M plays an essential role in transcriptional activation and signal transduction in Xiphophorus melanoma. Delfgaauw, J., Duschl, J., Wellbrock, C., Froschauer, C., Schartl, M., Altschmied, J. Gene (2003) [Pubmed]
  33. Assignment of the TP53 orthologue to a new linkage group (LG XIV) in fish of the genus Xiphophorus (Teleostei: Poeciliidae). Nairn, R.S., Coletta, L.D., McEntire, B.B., Walter, R.B., Morizot, D.C. Cancer Genet. Cytogenet. (1996) [Pubmed]
  34. Cloning and comparative sequence analysis of TP53 in Xiphophorus fish hybrid melanoma models. Kazianis, S., Gan, L., Della Coletta, L., Santi, B., Morizot, D.C., Nairn, R.S. Gene (1998) [Pubmed]
  35. A universal assay for vitellogenin in fish mucus and plasma. Van Veld, P.A., Rutan, B.J., Sullivan, C.A., Johnston, L.D., Rice, C.D., Fisher, D.F., Yonkos, L.T. Environ. Toxicol. Chem. (2005) [Pubmed]
  36. Sexually dimorphic age-related differences in the immunocytochemical distribution of somatostatin in the platyfish. Margolis-Nunno, H., Schreibman, M.P., Halpern-Sebold, L. Mech. Ageing Dev. (1987) [Pubmed]
  37. Sexually dimorphic effects of NMDA receptor antagonism on brain-pituitary-gonad axis development in the platyfish. Flynn, K.M., Miller, S.A., Sower, S.A., Schreibman, M.P. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2002) [Pubmed]
  38. Localization of cellular src mRNA during development and in the differentiated bipolar neurons of the adult neural retina in Xiphophorus. Raulf, F., Mäueler, W., Robertson, S.M., Schartl, M. Oncogene Res. (1989) [Pubmed]
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