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Chemical Compound Review

ACMC-1BF9L     sodium perchlorate

Synonyms: CPL 46, AG-H-03225, CHEMBL1644700, HSDB 5038, AC1LAX54, ...
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Disease relevance of sodium perchlorate


High impact information on sodium perchlorate

  • Two of the three major outer layers of the Chlamydomonas reinhardtii cell wall (W6 and W4) can be solubilized from living cells with sodium perchlorate or other chaotropes and will repolymerize in vitro to form milligram amounts of wall crystals [5].
  • The 52-kDa-labeled protein was the only isotopically labeled protein extracted from the labeled membranes with the chaotrope sodium perchlorate [6].
  • In vivo specific inhibition of NIS by sodium perchlorate led to a rapid iodine efflux from the liver, indicating that the sustained uptake was not attributable to an active retention mechanism but to permanent recycling of the effluent radioiodine via the high hepatic blood flow [7].
  • Lipoproteins in serum were separated on a column containing diethylaminoethyl-ligand nonporous polymer-based gel by elution with a step gradient of sodium perchlorate concentration, and detected by post-column reaction with a reagent containing cholesterol esterase and cholesterol oxidase [8].
  • We evaluated a method of measuring lactate dehydrogenase isoenzyme 1 (LD-1) selectively (Clin Chem 1987;33:991-2), in which all other LD isoenzymes were inhibited by adding sodium perchlorate to the reaction medium to a final concentration of 0.825 mol/L [9].

Chemical compound and disease context of sodium perchlorate


Biological context of sodium perchlorate

  • Prevention of overt metamorphosis by sodium perchlorate blockade prevented the development of noradrenergic (NA) splenic innervation in some, but not all, tadpoles examined [12].
  • The addition of salt (100 mM sodium perchlorate) to the aqueous environment surrounding the binding site of receptor and ligand was also shown to have a profound effect on side-chain hydrophilicity/hydrophobicity in the binding interface [13].
  • Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology [14].
  • Whereas acylation leads to a decrease of the alpha-helix content by 10% at the expense of the beta-sheet content, addition of sodium perchlorate results in the conversion of 10% of the protein secondary structure from beta-sheet to unordered [15].
  • Percent proximate composition, amino acid composition, and protein nutritive value were determined for the yeast cell biomass (YC), a sodium perchlorate extracted and isoelectrically precipitated protein concentrate (P-PC), and a sodium trimetaphosphate treated extract followed by isoelectrical precipitation (TMP-PC) [16].

Anatomical context of sodium perchlorate


Associations of sodium perchlorate with other chemical compounds


Gene context of sodium perchlorate


Analytical, diagnostic and therapeutic context of sodium perchlorate


  1. Identification of the transcribing DNA strand for the deoxynucleotide kinase gene of bacteriophage T2. Trimble, R.B., Maley, F. Biochemistry (1978) [Pubmed]
  2. Immunization against experimental Chagas' disease by using culture forms of Trypanosoma cruzi killed with a solution of sodium perchlorate. Kierszenbaum, F., Budzko, D.B. Infect. Immun. (1975) [Pubmed]
  3. Thyrotoxicity of sodium arsenate, sodium perchlorate, and their mixture in zebrafish Danio rerio. Liu, F.J., Wang, J.S., Theodorakis, C.W. Environ. Sci. Technol. (2006) [Pubmed]
  4. The thyroid endocrine disruptor perchlorate affects reproduction, growth, and survival of mosquitofish. Park, J.W., Rinchard, J., Liu, F., Anderson, T.A., Kendall, R.J., Theodorakis, C.W. Ecotoxicol. Environ. Saf. (2006) [Pubmed]
  5. Crystals of the Chlamydomonas reinhardtii cell wall: polymerization, depolymerization, and purification of glycoprotein monomers. Goodenough, U.W., Gebhart, B., Mecham, R.P., Heuser, J.E. J. Cell Biol. (1986) [Pubmed]
  6. NADPH-binding protein of the neutrophil superoxide-generating oxidase of guinea pigs. Ge, F., Guillory, R.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats. Faivre, J., Clerc, J., Gérolami, R., Hervé, J., Longuet, M., Liu, B., Roux, J., Moal, F., Perricaudet, M., Bréchot, C. Cancer Res. (2004) [Pubmed]
  8. Measurement of cholesterol of major serum lipoprotein classes by anion-exchange HPLC with perchlorate ion-containing eluent. Hirowatari, Y., Yoshida, H., Kurosawa, H., Doumitu, K.I., Tada, N. J. Lipid Res. (2003) [Pubmed]
  9. Inhibition of lactate dehydrogenase isoenzymes by sodium perchlorate evaluated. Sanders, G.T., van der Neut, E., van Straalen, J.P. Clin. Chem. (1990) [Pubmed]
  10. Filter-supported preparation of lambda phage DNA. Jakobi, R., Wiemann, S., Pyerin, W. Anal. Biochem. (1988) [Pubmed]
  11. Expression of sodium-iodide symporter mRNA in the thyroid gland of Xenopus laevis tadpoles: developmental expression, effects of antithyroidal compounds, and regulation by TSH. Opitz, R., Trubiroha, A., Lorenz, C., Lutz, I., Hartmann, S., Blank, T., Braunbeck, T., Kloas, W. J. Endocrinol. (2006) [Pubmed]
  12. Sympathetic innervation of the amphibian spleen: developmental studies in Xenopus laevis. Kinney, K.S., Felten, S.Y., Cohen, N. Dev. Comp. Immunol. (1996) [Pubmed]
  13. Reversed-phase liquid chromatography as a tool in the determination of the hydrophilicity/hydrophobicity of amino acid side-chains at a ligand-receptor interface in the presence of different aqueous environments. I. Effect of varying receptor hydrophobicity. Mant, C.T., Hodges, R.S. Journal of chromatography. A. (2002) [Pubmed]
  14. Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology. Tietge, J.E., Holcombe, G.W., Flynn, K.M., Kosian, P.A., Korte, J.J., Anderson, L.E., Wolf, D.C., Degitz, S.J. Environ. Toxicol. Chem. (2005) [Pubmed]
  15. Conformational changes upon dissociation of a globular protein from pea: a Fourier transform infrared spectroscopy study. Subirade, M., Gueguen, J., Pézolet, M. Biochim. Biophys. Acta (1994) [Pubmed]
  16. Composition and nutritive value of yeast biomass and yeast protein concentrates. Pacheco, M.T., Caballero-Córdoba, G.M., Sgarbieri, V.C. J. Nutr. Sci. Vitaminol. (1997) [Pubmed]
  17. The effect of sodium perchlorate and ionizing irradiation on the thyroid parenchymal and pituitary thyrotropic cells. Pajer, Z., Kalisnik, M. Oncology (1991) [Pubmed]
  18. Effects of thyroid hormone deprivation on immunity in postmetamorphic frogs. Rollins-Smith, L.A., Davis, A.T., Blair, P.J. Dev. Comp. Immunol. (1993) [Pubmed]
  19. Contribution of ammonium ions to the lethality and antimetamorphic effects of ammonium perchlorate. Goleman, W.L., Carr, J.A. Environ. Toxicol. Chem. (2006) [Pubmed]
  20. Expression of the human sodium/iodide symporter (hNIS) in xenotransplanted human thyroid carcinoma. Smit, J.W., Schröder-van der Elst, J.P., Karperien, M., Que, I., Romijn, J.A., van der Heide, D. Exp. Clin. Endocrinol. Diabetes (2001) [Pubmed]
  21. Expression of class II major histocompatibility complex antigens on adult T cells in Xenopus is metamorphosis-dependent. Rollins-Smith, L.A., Blair, P. Dev. Immunol. (1990) [Pubmed]
  22. High-performance liquid chromatography of imipramine and six metabolites in human plasma and urine. Nielsen, K.K., Brøsen, K. J. Chromatogr. (1993) [Pubmed]
  23. Investigation of perchlorate, phosphate and ion-pairing eluent modifiers for the separation of cephalosporin epimers. Kennedy, J.H., Olsen, B.A. J. Chromatogr. (1987) [Pubmed]
  24. Thyroid gland function and growth in IGF binding protein-1 transgenic mice. Modric, T., Rajkumar, K., Murphy, L.J. Eur. J. Endocrinol. (1999) [Pubmed]
  25. Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations. Bradford, C.M., Rinchard, J., Carr, J.A., Theodorakis, C. Environ. Sci. Technol. (2005) [Pubmed]
  26. Effect of perchlorate treatment on mitochondrial MAO-A and -B activities. Arai, Y., Oreland, L., Kinemuchi, H. Med. Biol. (1984) [Pubmed]
  27. Rapid isolation of RNA using proteinase K and sodium perchlorate. Lizardi, P.M., Engelberg, A. Anal. Biochem. (1979) [Pubmed]
  28. Equilibrium unfolding of dimeric and engineered monomeric forms of lambda Cro (F58W) repressor and the effect of added salts: evidence for the formation of folded monomer induced by sodium perchlorate. Maity, H., Mossing, M.C., Eftink, M.R. Arch. Biochem. Biophys. (2005) [Pubmed]
  29. Determination of pyronaridine in whole blood by automated solid phase extraction and high-performance liquid chromatography. Blessborn, D., Lindegårdh, N., Ericsson, O., Hellgren, U., Bergqvist, Y. Therapeutic drug monitoring. (2003) [Pubmed]
  30. Evidence of molten globule like state(s) of interferon gamma in acidic and sodium perchlorate solutions. Nandi, P.K. Int. J. Biol. Macromol. (1998) [Pubmed]
  31. Salt-induced formation of the molten globule state of cytochrome c studied by isothermal titration calorimetry. Hamada, D., Kidokoro, S., Fukada, H., Takahashi, K., Goto, Y. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  32. Rat mammary gland atypia produced by iodine blockade with perchlorate. Eskin, B.A., Shuman, R., Krouse, T., Merion, J.A. Cancer Res. (1975) [Pubmed]
  33. Cell wall lytic enzyme released by mating gametes of Chlamydomonas reinhardtii is a metalloprotease and digests the sodium perchlorate-insoluble component of cell wall. Matsuda, Y., Saito, T., Yamaguchi, T., Kawase, H. J. Biol. Chem. (1985) [Pubmed]
  34. B to Z transitions of the short DNA hairpins formed from the oligomer sequences: d[(CG)3X4(CG)3] (X = A, T, G, C). Amaratunga, M., Pancoska, P., Paner, T.M., Benight, A.S. Nucleic Acids Res. (1990) [Pubmed]
  35. Rectal perchlorate for unconscious patients prior to brain scintigraphy with pertechnetate: concise communication. Turner, D.A., Ali, A.A., Ochart, M.G., Sukerkar, A.N., Fordham, E.W., Rayudu, G.V. J. Nucl. Med. (1977) [Pubmed]
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