- Specific and sustained down-regulation of genes involved in fatty acid metabolism is not a hallmark of progression to cardiac failure in mice. de Brouwer, K.F., Degens, H., Aartsen, W.M., Lindhout, M., Bitsch, N.J., Gilde, A.J., Willemsen, P.H., Janssen, B.J., van der Vusse, G.J., van Bilsen, M. J. Mol. Cell. Cardiol. (2006)