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Pletjushkina, O.Y. et al.

Pletjushkina, Lyamzaev, Popova, Nepryakhina, Ivanova, Domnina, Chernyak, Skulachev,

Effect of oxidative stress on dynamics of mitochondrial reticulum.

Fission of the mitochondrial reticulum (the thread-grain transition) and following gathering of mitochondria in the perinuclear area are induced by oxidative stress. It is shown that inhibitors of the respiratory chain (piericidin and myxothiazol) cause fission of mitochondria in HeLa cells and fibroblasts, whereas a mitochondria-targeted antioxidant (MitoQ) inhibits this effect. Hydrogen peroxide also induced the fission, which was stimulated by the inhibitors of respiration and suppressed by MitoQ. In untreated cells, the mitochondrial reticulum consisted of numerous electrically-independent fragments. Prolonged treatment with MitoQ resulted in drastic increase in size and decrease in number of these fragments. Local photodamage of mitochondria caused immediate depolarization of a large fraction of the mitochondrial network in MitoQ-treated cells. Our data indicate that the thread-grain transition of mitochondria depends on production of reactive oxygen species (ROS) in initial segments of the respiratory chain and is a necessary step in the process of elimination of mitochondria (mitoptosis).[1]

References

Effect of oxidative stress on dynamics of mitochondrial reticulum. Pletjushkina, O.Y., Lyamzaev, K.G., Popova, E.N., Nepryakhina, O.K., Ivanova, O.Y., Domnina, L.V., Chernyak, B.V., Skulachev, V.P. Biochim. Biophys. Acta (2006) [Pubmed]

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