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Chemical Compound Review

Myxothiazol     (2E,4R,5R,6E)-3,5-dimethoxy- 4-methyl-7-[2...

Synonyms: CHEBI:25461, LS-74196, CPD0-1244, AC1O5NJ4, C25H33N3O3S2, ...
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Disease relevance of Myxothiazol

  • Several spontaneous mutants of the photosynthetic bacterium Rhodobacter capsulatus resistant to myxothiazol, stigmatellin and mucidin--inhibitors of the ubiquinol: cytochrome c oxidoreductase (cyt bc1 complex)--were isolated [1].
  • ROS generation during hypoxia was attenuated by myxothiazol, but not by diphenyleneiodonium or the nitric-oxide synthase inhibitor L-nitroarginine [2].
  • Myxothiazol, an antibiotic from Myxococcus fulvus, which inhibits mitochondrial respiration in the bc1 complex of the respiratory chain, has effects on the redox components of isolated succinate-cytochrome c reductase complex which suggest that it interacts with both cytochrome b and the iron-sulfur protein of the bc1 complex [3].
  • The biosynthetic mta gene cluster responsible for myxothiazol formation from the fruiting body forming myxobacterium Stigmatella aurantiaca DW4/3-1 was sequenced and analyzed [4].
  • Myxothiazol (0.6 microM), a site III mitochondrial inhibitor, blocked the protection of menadione and significantly increased infarction to 25.2 +/- 3.8% [5].

High impact information on Myxothiazol

  • The positions of the four iron centers within the bc1 complex and the binding sites of the two specific respiratory inhibitors antimycin A and myxothiazol were identified [6].
  • Myxothiazol-resistant transformants have been created by introducing a nucleotide substitution into the cob gene [7].
  • To activate the involved proteins posttranslationally, they were coexpressed with the phosphopantetheinyltransferase MtaA from the myxothiazol biosynthetic gene cluster [8].
  • Furthermore, cells treated with mitochondrial inhibitors, such as rotenone and myxothiazol, provided direct evidence that PHDs remain active in hypoxic cells lacking functional mitochondria [9].
  • Furthermore, the hypoxic activation of p38alpha and HIF-1 was abolished by myxothiazol, a mitochondrial complex III inhibitor, and glutathione peroxidase 1 (GPX1), a scavenger of hydrogen peroxide [10].

Chemical compound and disease context of Myxothiazol


Biological context of Myxothiazol


Anatomical context of Myxothiazol


Associations of Myxothiazol with other chemical compounds


Gene context of Myxothiazol


Analytical, diagnostic and therapeutic context of Myxothiazol


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  2. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. Vanden Hoek, T.L., Becker, L.B., Shao, Z., Li, C., Schumacker, P.T. J. Biol. Chem. (1998) [Pubmed]
  3. An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex. von Jagow, G., Ljungdahl, P.O., Graf, P., Ohnishi, T., Trumpower, B.L. J. Biol. Chem. (1984) [Pubmed]
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  13. Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes. Kulisz, A., Chen, N., Chandel, N.S., Shao, Z., Schumacker, P.T. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  14. A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria. Mahmud, T., Bode, H.B., Silakowski, B., Kroppenstedt, R.M., Xu, M., Nordhoff, S., Höfle, G., Müller, R. J. Biol. Chem. (2002) [Pubmed]
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  17. Metabolic Engineering of Pseudomonas putida for Methylmalonyl-CoA Biosynthesis to Enable Complex Heterologous Secondary Metabolite Formation. Gross, F., Ring, M.W., Perlova, O., Fu, J., Schneider, S., Gerth, K., Kuhlmann, S., Stewart, A.F., Zhang, Y., M??ller, R. Chem. Biol. (2006) [Pubmed]
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  19. The control of mitochondrial oxidations by complex III in rat muscle and liver mitochondria. Implications for our understanding of mitochondrial cytopathies in man. Taylor, R.W., Birch-Machin, M.A., Bartlett, K., Lowerson, S.A., Turnbull, D.M. J. Biol. Chem. (1994) [Pubmed]
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