Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Steiner, H. et al.

Regulation of growth of prostate cancer cells selected in the presence of interleukin-6 by the anti-interleukin-6 antibody CNTO 328.

BACKGROUND: Interleukin-6 ( IL-6) is a multifunctional regulator of cellular events in prostate cancer. LNCaP- IL-6+ cells selected in the presence of IL-6 were taken for assessment of effects of the chimeric monoclonal anti- IL-6 antibody CNTO 328. METHODS: Cell viability was assessed after treatment with CNTO 328 by the ATP assay. Expression of Bcl-2 and Bax and activation of signaling pathways were evaluated by Western analysis. Nude mice were inoculated with LNCaP- IL-6+ cells and treated with CNTO 328. The tumors were analyzed by immunohistochemistry for expression of Ki-67, tissue transglutaminase, and vascular endothelial growth factor. RESULTS: CNTO 328 caused a statistically significant inhibition of cell viability. The protein levels of Bcl-2 and the phosphorylation of ERK1/2 mitogen- activated protein kinases were decreased by the anti- IL-6 antibody. Treatment with CNTO 328 yielded an increase in the phosphorylation of signal transducers and activators of transcription factor 3. The mean tumor volume in animals inoculated with LNCaP- IL-6+ cells and treated with CNTO 328 was insignificantly lower than that in animals treated with the control antibody. There was a statistically significant decrease in the percentage of Ki-67-positive cells in CNTO 328-treated tumors. CONCLUSION: CNTO 328 has a potential in prostate cancer therapy and could be further tested in various combination experimental treatments. Prostate (c) 2006 Wiley-Liss, Inc.[1]

References

Regulation of growth of prostate cancer cells selected in the presence of interleukin-6 by the anti-interleukin-6 antibody CNTO 328. Steiner, H., Cavarretta, I.T., Moser, P.L., Berger, A.P., Bektic, J., Dietrich, H., Zaki, M.H., Nakada, M., Hobisch, A., Nemeth, J.A., Culig, Z. Prostate (2006) [Pubmed]

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