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Katori, H. et al.

Katori, Tsukuda, Taguchi,

Analysis of efficacy and toxicity of chemotherapy with cisplatin, 5-fluorouracil, methotrexate and leucovorin (PFML) and radiotherapy in the treatment of locally advanced squamous cell carcinoma of the head and neck.

PURPOSE: The aim of this study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy using cisplatin ( CDDP), 5-fluorouracil (5-FU), methotrexate (MTX) and leucovorin (LV) (PFML) in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). METHODS: Seventy-seven patients with previously untreated stages III-IV SCCHN were included in this trial. Patients received two cycles of chemotherapy repeated every 4 weeks. The chemotherapy regimen consisted CDDP (60 mg/m(2), day 4), 5-FU (600 mg/m(2) given over 24 h for 5 days, days 1-5), MTX (30 mg/m(2), day 1) and LV (20 mg/m(2), days 1-5). Radiation was targeted to begin on the starting day of chemotherapy, day 1. The total radiation dose to the primary site and neck lymph nodes was 70.0 Gy. When grade >/=3 toxicities were observed frequently, radiotherapy and/or chemotherapy were delayed or reduced. RESULTS: The main toxicities were mucositis (grade >/=3, 39%), leukocytopenia (grade >/=3, 34%) and neutropenia (grade >/=3, 30%). The overall clinical response rate and the pathological complete response (CR) were 94% (72/77) and 71% (55/77). The primary site CR and neck lymph node CR were 79% (61/77) and 85% (44/52), and 3-year survival rate was 73%. CONCLUSIONS: This concurrent chemoradiotherapy with PFML was safe and well tolerated. The high CR rate justifies further evaluation of this chemoradiotherapy modality in locally advanced SCCHN patients.[1]

References

Analysis of efficacy and toxicity of chemotherapy with cisplatin, 5-fluorouracil, methotrexate and leucovorin (PFML) and radiotherapy in the treatment of locally advanced squamous cell carcinoma of the head and neck. Katori, H., Tsukuda, M., Taguchi, T. Cancer Chemother. Pharmacol. (2007) [Pubmed]

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