The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

CD8(+)CD28(-) Regulatory T Lymphocytes Prevent Experimental Inflammatory Bowel Disease in Mice.

Background & Aims: Immune responses to innocuous intestinal antigens appear tightly controlled by regulatory T lymphocytes. While CD4(+) T lymphocytes have recently attracted the most attention, CD8(+) regulatory T-cell populations are also believed to play an important role in control of mucosal immunity. However, CD8(+) regulatory T-cell function has mainly been studied in vitro and no direct in vivo evidence exists that they can control mucosal immune responses. We investigated the capacity of CD8(+)CD28(-) T cells to prevent experimental inflammatory bowel disease (IBD) in mice. Methods: CD8(+)CD28(-) regulatory T cells were isolated from unmanipulated mice and tested for their capacity to inhibit T-cell activation in allogeneic mixed lymphocyte cultures in vitro and to prevent IBD induced by injection of CD4(+)CD45RB(high) cells into syngeneic immunodeficient RAG-2 mutant mice. Results: CD8(+)CD28(-) T lymphocytes inhibited proliferation and interferon gamma production by CD4(+) responder T cells in vitro. CD8(+)CD28(-) regulatory T cells freshly isolated from spleen or gut efficiently prevented IBD induced by transfer of colitogenic T cells into immunodeficient hosts. Regulatory CD8(+)CD28(-) T cells incapable of producing interleukin-10 did not prevent colitis. Moreover, IBD induced with colitogenic T cells incapable of responding to transforming growth factor beta could not be prevented with CD8(+)CD28(-) regulatory T cells. CD8(+)CD28(+) T cells did not inhibit in vitro or in vivo immune responses. Conclusions: Our findings show that naturally occurring CD8(+)CD28(-) regulatory T lymphocytes can prevent experimental IBD in mice and suggest that these cells may play an important role in control of mucosal immunity.[1]

References

  1. CD8(+)CD28(-) Regulatory T Lymphocytes Prevent Experimental Inflammatory Bowel Disease in Mice. M??nager-Marcq, I., Pomi??, C., Romagnoli, P., van Meerwijk, J.P. Gastroenterology (2006) [Pubmed]
 
WikiGenes - Universities