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Gene Review

Casp14  -  caspase 14

Mus musculus

Synonyms: CASP-14, Caspase-14, MICE, Mini-ICE, mini-ICE
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Disease relevance of Casp14


Psychiatry related information on Casp14

  • Long-Term Memory Deficits in Pavlovian Fear Conditioning in Ca2+/Calmodulin Kinase Kinase {alpha}-Deficient Mice [6].
  • METHODS: Mice treated with either methionine (MET) (5.2 mmol/kg/SC/twice daily) or valproate (1.5 mmol/kg/SC/twice daily) or MET+ valproate combination were tested for prepulse inhibition of startle (PPI) and social interaction (SI) [7].
  • 1. Mice were subjected to gastrectomy (GX) or food deprivation (24 h) [8].
  • MEASUREMENTS AND RESULTS: Mice homozygous for the BMAL1/Mop3 deletion showed an attenuated rhythm of sleep and wakefulness distribution across the 24-hr period [9].
  • METHODS: Mice were tested using locomotor activity as well as a functional observational battery (FOB) both before and after a regimen of daily exposures to various concentrations of TCE [10].

High impact information on Casp14


Chemical compound and disease context of Casp14


Biological context of Casp14


Anatomical context of Casp14


Associations of Casp14 with chemical compounds

  • Calcium Channel Blocker Azelnidipine Reduces Glucose Intolerance in Diabetic Mice via Different Mechanism Than Angiotensin Receptor Blocker Olmesartan [30].
  • METHODS: Mice were randomly assigned to receive oxygen or isoflurane for 30 min with 15 min of washout [31].
  • METHODS: Mice were treated with cisplatin with or without administration of OTC [32].
  • Purification of caspase-14 from native skin with subsequent N-terminal sequencing of the small subunit and tryptic digest analysis of the large subunit revealed an atypical processing site between Ile152 and Lys153, which distinguishes it from other caspases described to date that are processed at aspartate residues [33].
  • METHODS: Mice fed a diet containing 10% creatine, came to accumulate phosphocreatine and to enhance hepatic ATP levels and mitochondrial oxidative phosphorylation activities [34].

Regulatory relationships of Casp14

  • Caspase-14 is a developmentally regulated and tissue restricted member of the caspase family present in mammals [35].

Other interactions of Casp14

  • Herein we report the characterization of a novel caspase, MICE (for mini-ICE), also designated caspase-14, that possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from all adult tissues examined [36].
  • Transient overexpression of murine caspase-14 in mammalian cells did not elicit cell death and did not interfere with caspase-8-induced apoptosis [24].
  • These observations suggest that caspase-14 may play a role in death receptor and granzyme B-induced apoptosis [23].
  • Demonstration of in vitro cleavage of recombinant mouse caspase-14 by calpain I in the present study lends support to this hypothesis, further implicating cross-talk between different protease families in the pathophysiology of ischemic neural cell death [37].
  • On non-denaturing protein gels, native caspase-14 has a relative electrophoretic mobility of approximately 80kDa, which resolves into caspase-14 proform, large and small subunit in SDS-polyacrylamide [33].

Analytical, diagnostic and therapeutic context of Casp14


  1. Comparison of ischemic preconditioning and intermittent and continuous inflow occlusion in the murine liver. Rüdiger, H.A., Kang, K.J., Sindram, D., Riehle, H.M., Clavien, P.A. Ann. Surg. (2002) [Pubmed]
  2. Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia. Emanueli, C., Van Linthout, S., Salis, M.B., Monopoli, A., Del Soldato, P., Ongini, E., Madeddu, P. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  3. Increased Myeloid Cell Responses to M-CSF and RANKL Cause Bone Loss and Inflammation in SH3BP2 "Cherubism" Mice. Ueki, Y., Lin, C.Y., Senoo, M., Ebihara, T., Agata, N., Onji, M., Saheki, Y., Kawai, T., Mukherjee, P.M., Reichenberger, E., Olsen, B.R. Cell (2007) [Pubmed]
  4. Hapten-specific responses to the phenyltrimethylamino hapten. III. Mice whose delayed-type hypersensitivity responses cannot be abrogated by the presence of anti-idiotypic suppressor T cells lack a critical modulatory T cell function. Jayaraman, S., Bellone, C.J. J. Exp. Med. (1982) [Pubmed]
  5. Mammary tumors, hepatocellular carcinomas, and pancreatic islet changes in C3H-Avy Mice. Sass, B., Vernon, M.L., Peters, R.L., Kelloff, G.J. J. Natl. Cancer Inst. (1978) [Pubmed]
  6. Long-Term Memory Deficits in Pavlovian Fear Conditioning in Ca2+/Calmodulin Kinase Kinase {alpha}-Deficient Mice. Blaeser, F., Sanders, M.J., Truong, N., Ko, S., Wu, L.J., Wozniak, D.F., Fanselow, M.S., Zhuo, M., Chatila, T.A. Mol. Cell. Biol. (2006) [Pubmed]
  7. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Tremolizzo, L., Doueiri, M.S., Dong, E., Grayson, D.R., Davis, J., Pinna, G., Tueting, P., Rodriguez-Menendez, V., Costa, E., Guidotti, A. Biol. Psychiatry (2005) [Pubmed]
  8. Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice. Salehi, A., Chen, D., Håkanson, R., Nordin, G., Lundquist, I. J. Physiol. (Lond.) (1999) [Pubmed]
  9. Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation. Laposky, A., Easton, A., Dugovic, C., Walisser, J., Bradfield, C., Turek, F. Sleep. (2005) [Pubmed]
  10. Tolerance and sensitization to inhaled 1,1,1-trichloroethane in mice: results from open-field behavior and a functional observational battery. Bowen, S.E., Balster, R.L. Psychopharmacology (Berl.) (2006) [Pubmed]
  11. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D.Y., Nakayama, K. Cell (1996) [Pubmed]
  12. Developmental biology. Mice with half a mind. Holder, N., Maden, M. Nature (1992) [Pubmed]
  13. Perspectives: microbiology. Mice are not furry petri dishes. Bull, J., Levin, B. Science (2000) [Pubmed]
  14. Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin Mice. Berland, R., Fernandez, L., Kari, E., Han, J.H., Lomakin, I., Akira, S., Wortis, H.H., Kearney, J.F., Ucci, A.A., Imanishi-Kari, T. Immunity (2006) [Pubmed]
  15. Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-beta Receptor. Marie, J.C., Liggitt, D., Rudensky, A.Y. Immunity (2006) [Pubmed]
  16. Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Maurer, K.J., Ihrig, M.M., Rogers, A.B., Ng, V., Bouchard, G., Leonard, M.R., Carey, M.C., Fox, J.G. Gastroenterology (2005) [Pubmed]
  17. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Sugimoto, K., Hanai, H., Tozawa, K., Aoshi, T., Uchijima, M., Nagata, T., Koide, Y. Gastroenterology (2002) [Pubmed]
  18. Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction. Verdú, E.F., Bercík, P., Bergonzelli, G.E., Huang, X.X., Blennerhasset, P., Rochat, F., Fiaux, M., Mansourian, R., Corthésy-Theulaz, I., Collins, S.M. Gastroenterology (2004) [Pubmed]
  19. Transgenic Mice Expressing the p75 CCAAT-Displacement Protein/Cut Homeobox Isoform Develop a Myeloproliferative Disease-Like Myeloid Leukemia. Cadieux, C., Fournier, S., Peterson, A.C., B??dard, C., Bedell, B.J., Nepveu, A. Cancer Res. (2006) [Pubmed]
  20. Recombinant Soluble Forms of Extracellular TLR4 Domain and MD-2 Inhibit Lipopolysaccharide Binding on Cell Surface and Dampen Lipopolysaccharide-Induced Pulmonary Inflammation in Mice. Mitsuzawa, H., Nishitani, C., Hyakushima, N., Shimizu, T., Sano, H., Matsushima, N., Fukase, K., Kuroki, Y. J. Immunol. (2006) [Pubmed]
  21. Caspase-14 but not caspase-3 is processed during the development of fetal mouse epidermis. Fischer, H., Rossiter, H., Ghannadan, M., Jaeger, K., Barresi, C., Declercq, W., Tschachler, E., Eckhart, L. Differentiation (2005) [Pubmed]
  22. Tolerance of Mice to Lipopolysaccharide is Correlated with Inhibition of Caspase-3-mediated Apoptosis in Mouse Liver Cells. Luan, J., Zhou, B., Ding, H., Qi, Z. Acta Biochim. Biophys. Sin. (Shanghai) (2007) [Pubmed]
  23. Identification and characterization of murine caspase-14, a new member of the caspase family. Ahmad, M., Srinivasula, S.M., Hegde, R., Mukattash, R., Fernandes-Alnemri, T., Alnemri, E.S. Cancer Res. (1998) [Pubmed]
  24. Identification of a new caspase homologue: caspase-14. Van de Craen, M., Van Loo, G., Pype, S., Van Criekinge, W., Van den brande, I., Molemans, F., Fiers, W., Declercq, W., Vandenabeele, P. Cell Death Differ. (1998) [Pubmed]
  25. Subcutaneous Fat Modulates Insulin Sensitivity in Mice by Regulating TNF-alpha Expression in Visceral Fat. Ishikawa, K., Takahashi, K., Bujo, H., Hashimoto, N., Yagui, K., Saito, Y. Horm. Metab. Res. (2006) [Pubmed]
  26. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. Lippens, S., Kockx, M., Knaapen, M., Mortier, L., Polakowska, R., Verheyen, A., Garmyn, M., Zwijsen, A., Formstecher, P., Huylebroeck, D., Vandenabeele, P., Declercq, W. Cell Death Differ. (2000) [Pubmed]
  27. COX-2 inhibitor celecoxib suppresses tumor growth and lung metastasis of a murine mammary cancer. Yoshinaka, R., Shibata, M.A., Morimoto, J., Tanigawa, N., Otsuki, Y. Anticancer Res. (2006) [Pubmed]
  28. CD8(+)CD28(-) Regulatory T Lymphocytes Prevent Experimental Inflammatory Bowel Disease in Mice. M??nager-Marcq, I., Pomi??, C., Romagnoli, P., van Meerwijk, J.P. Gastroenterology (2006) [Pubmed]
  29. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Takaishi, S., Cui, G., Frederick, D.M., Carlson, J.E., Houghton, J., Varro, A., Dockray, G.J., Ge, Z., Whary, M.T., Rogers, A.B., Fox, J.G., Wang, T.C. Gastroenterology (2005) [Pubmed]
  30. Calcium Channel Blocker Azelnidipine Reduces Glucose Intolerance in Diabetic Mice via Different Mechanism Than Angiotensin Receptor Blocker Olmesartan. Iwai, M., Li, H.S., Chen, R., Shiuchi, T., Wu, L., Min, L.J., Li, J.M., Tsuda, M., Suzuki, J., Tomono, Y., Tomochika, H., Mogi, M., Horiuchi, M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  31. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. Tsutsumi, Y.M., Patel, H.H., Lai, N.C., Takahashi, T., Head, B.P., Roth, D.M. Anesthesiology (2006) [Pubmed]
  32. Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury. Lee, S., Moon, S.O., Kim, W., Sung, M.J., Kim, D.H., Kang, K.P., Jang, Y.B., Lee, J.E., Jang, K.Y., Lee, S.Y., Park, S.K. Nephrol. Dial. Transplant. (2006) [Pubmed]
  33. Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation. Chien, A.J., Presland, R.B., Kuechle, M.K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  34. Inhibition of tumor necrosis factor-induced apoptosis in transgenic mouse liver expressing creatine kinase. Hatano, E., Tanaka, A., Kanazawa, A., Tsuyuki, S., Tsunekawa, S., Iwata, S., Takahashi, R., Chance, B., Yamaoka, Y. Liver Int. (2004) [Pubmed]
  35. Activation and substrate specificity of caspase-14. Mikolajczyk, J., Scott, F.L., Krajewski, S., Sutherlin, D.P., Salvesen, G.S. Biochemistry (2004) [Pubmed]
  36. Caspase-14 is a novel developmentally regulated protease. Hu, S., Snipas, S.J., Vincenz, C., Salvesen, G., Dixit, V.M. J. Biol. Chem. (1998) [Pubmed]
  37. Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Krajewska, M., Rosenthal, R.E., Mikolajczyk, J., Stennicke, H.R., Wiesenthal, T., Mai, J., Naito, M., Salvesen, G.S., Reed, J.C., Fiskum, G., Krajewski, S. Exp. Neurol. (2004) [Pubmed]
  38. Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis. Okada, K., Minamino, T., Tsukamoto, Y., Liao, Y., Tsukamoto, O., Takashima, S., Hirata, A., Fujita, M., Nagamachi, Y., Nakatani, T., Yutani, C., Ozawa, K., Ogawa, S., Tomoike, H., Hori, M., Kitakaze, M. Circulation (2004) [Pubmed]
  39. Interleukin 1-dependent and -independent mouse melanoma metastases. Anasagasti, M.J., Olaso, E., Calvo, F., Mendoza, L., Martin, J.J., Bidaurrazaga, J., Vidal-Vanaclocha, F. J. Natl. Cancer Inst. (1997) [Pubmed]
  40. Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. Fickert, P., Zollner, G., Fuchsbichler, A., Stumptner, C., Weiglein, A.H., Lammert, F., Marschall, H.U., Tsybrovskyy, O., Zatloukal, K., Denk, H., Trauner, M. Gastroenterology (2002) [Pubmed]
  41. Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism. Riehl, T., Cohn, S., Tessner, T., Schloemann, S., Stenson, W.F. Gastroenterology (2000) [Pubmed]
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