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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Developmentally regulated expression of MSX1, MSX2 and fgfs in the developing mouse cranial base.

Objective: To examine the expression pattern of the Fgf and Msx genes in cranial base development. Materials and Methods: To detect the expression of these genes, antisense riboprobes were synthesized by in vitro transcription. Radioactive in situ hybridization was performed on parasagittal sections of embryonic mouse heads. Results: Msx2 was observed in the underlying perichondrium at restricted stages. Msx1 was not observed in cranial base development. Fgf1 was localized in osteogenic cells from the time of ossification; Fgf10 was highly expressed in the occipital-vertebral joint during E13 to E14; Fgf2, Fgf7, and Fgf18 were localized in the perichondria; Fgf12 was transitorily expressed at early chondrocranium; Fgf9 was seen in the hypertrophic chondrocytes. Conclusions: The Fgf and Msx gene expression in the cranial base was different from that of other skeletons.[1]


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