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Gene Review

Fgf7  -  fibroblast growth factor 7

Mus musculus

Synonyms: FGF-7, Fgf-7, Fibroblast growth factor 7, HBGF-7, Heparin-binding growth factor 7, ...
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Disease relevance of Fgf7


Psychiatry related information on Fgf7

  • KGF expression was also detected in tissues isolated from human embryos, suggesting similar functions for KGF in human development [4].

High impact information on Fgf7

  • It is shown here that activated gamma delta T cells obtained from skin and intestine express the epithelial cell mitogen keratinocyte growth factor (KGF) [5].
  • In contrast, intraepithelial alpha beta T cells, as well as all lymphoid alpha beta and gamma delta T cell populations tested, did not produce KGF or promote the growth of cultured epithelial cells [5].
  • The pattern of binding competition by related fibroblast growth factors (FGFs) indicated that this receptor had high affinity for acidic FGF as well as KGF [6].
  • Among several transformed foci identified, one demonstrated the acquisition of specific high-affinity KGF binding sites [6].
  • The KGF transcript was present in stromal cells derived from epithelial tissues [7].

Chemical compound and disease context of Fgf7


Biological context of Fgf7

  • Keratinocyte growth factor is required for hair development but not for wound healing [13].
  • Over time, their fur developed a matted appearance, very similar to that of the rough mouse, whose recessive mutation maps at or near the KGF locus on mouse chromosome 2 [13].
  • The upregulation of KGF after epithelial injury suggested it had an important role in tissue repair [1].
  • These results demonstrate that the peptide binds directly and specifically to KGF and argue that this region of the receptor constitutes part or all of the KGF binding site [14].
  • KGF also stimulated the rapid tyrosine phosphorylation of a 90-kDa protein in Balb/MK cells but not in NIH/3T3 fibroblasts [15].

Anatomical context of Fgf7


Associations of Fgf7 with chemical compounds

  • Mutant proteins, produced in bacteria, were tested for their ability to bind heparin, bind and activate the KGF receptor, and induce DNA synthesis [20].
  • However, deletion of 29 residues resulted in significantly reduced ability to stimulate KGF receptor tyrosine-kinase activity and DNA synthesis, although this mutant bound the receptor at high affinity [20].
  • Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor [21].
  • Pretreatment of tumor cells with suramin or neutralizing antibodies to bFGF or keratinocyte growth factor (KGF) circumvented resistance in one of the tumor lines, confirming autocrine-mediated resistance [22].
  • In addition, KGF is apparently interacting with an as yet unidentified type of low affinity binding site that is not affected by chlorate or heparan sulfate-degrading enzymes [23].

Physical interactions of Fgf7


Regulatory relationships of Fgf7


Other interactions of Fgf7

  • No difference could be observed between transgenic and control lungs in either the level or distribution of Bmp4, Wnt2 and Fgf7 RNA [31].
  • Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors [15].
  • Altogether, our results suggest that the amino-terminal part of KGF and bFGF plays an important role in determining their receptor binding specificity [32].
  • High affinity binding of KGF was acquired only when also domain 2 in this chimera was replaced by its homologous domain from FGFR2 [33].
  • To further evaluate the roles of FGFs in tooth development, we analyzed the roles of FGF-3, FGF-7, and FGF-10 in developing mouse teeth [34].

Analytical, diagnostic and therapeutic context of Fgf7

  • Preclinical data from several animal models demonstrated that recombinant human KGF could enhance the regenerative capacity of epithelial tissues and protect them from a variety of toxic exposures [1].
  • In situ hybridization studies revealed highest levels of KGF mRNA expression in the dermis at the wound edge and in the hypodermis below the wound [19].
  • Furthermore, after approximately 24 h, KGF as well as TGF alpha induced EGFR down-regulation based on Western blot analysis and 125I-EGF binding [35].
  • Treatment with both KGF and stem cell factor (previously shown to enhance intestinal crypt survival after total-body irradiation) increased the number of surviving crypt cells after irradiation to levels similar to that in animals treated with KGF alone [2].
  • Moreover, functional assays in organ culture and in vivo and analysis of agents regulating KGF expression reinforced the idea that KGF acts predominantly on epithelial cells [36].


  1. Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Finch, P.W., Rubin, J.S. Adv. Cancer Res. (2004) [Pubmed]
  2. Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor. Khan, W.B., Shui, C., Ning, S., Knox, S.J. Radiat. Res. (1997) [Pubmed]
  3. Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Kitsberg, D.I., Leder, P. Oncogene (1996) [Pubmed]
  4. Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions. Finch, P.W., Cunha, G.R., Rubin, J.S., Wong, J., Ron, D. Dev. Dyn. (1995) [Pubmed]
  5. Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Boismenu, R., Havran, W.L. Science (1994) [Pubmed]
  6. Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Miki, T., Fleming, T.P., Bottaro, D.P., Rubin, J.S., Ron, D., Aaronson, S.A. Science (1991) [Pubmed]
  7. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Finch, P.W., Rubin, J.S., Miki, T., Ron, D., Aaronson, S.A. Science (1989) [Pubmed]
  8. Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse. Yang, H., Antony, P.A., Wildhaber, B.E., Teitelbaum, D.H. J. Immunol. (2004) [Pubmed]
  9. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. Tichelaar, J.W., Lu, W., Whitsett, J.A. J. Biol. Chem. (2000) [Pubmed]
  10. Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents. Braun, S., Krampert, M., Bod??, E., K??min, A., Born-Berclaz, C., Paus, R., Werner, S. J. Cell. Sci. (2006) [Pubmed]
  11. Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice. Panoskaltsis-Mortari, A., Lacey, D.L., Vallera, D.A., Blazar, B.R. Blood (1998) [Pubmed]
  12. Keratinocyte growth factor increases fatty acid mobilization and hepatic triglyceride secretion in rats. Nonogaki, K., Pan, X.M., Moser, A.H., Staprans, I., Feingold, K.R., Grunfeld, C. Endocrinology (1995) [Pubmed]
  13. Keratinocyte growth factor is required for hair development but not for wound healing. Guo, L., Degenstein, L., Fuchs, E. Genes Dev. (1996) [Pubmed]
  14. A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site. Bottaro, D.P., Fortney, E., Rubin, J.S., Aaronson, S.A. J. Biol. Chem. (1993) [Pubmed]
  15. Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. Bottaro, D.P., Rubin, J.S., Ron, D., Finch, P.W., Florio, C., Aaronson, S.A. J. Biol. Chem. (1990) [Pubmed]
  16. Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. Revest, J.M., Suniara, R.K., Kerr, K., Owen, J.J., Dickson, C. J. Immunol. (2001) [Pubmed]
  17. Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle. Rosenquist, T.A., Martin, G.R. Dev. Dyn. (1996) [Pubmed]
  18. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. Guo, L., Yu, Q.C., Fuchs, E. EMBO J. (1993) [Pubmed]
  19. Large induction of keratinocyte growth factor expression in the dermis during wound healing. Werner, S., Peters, K.G., Longaker, M.T., Fuller-Pace, F., Banda, M.J., Williams, L.T. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  20. Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants. Ron, D., Bottaro, D.P., Finch, P.W., Morris, D., Rubin, J.S., Aaronson, S.A. J. Biol. Chem. (1993) [Pubmed]
  21. Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor. LaRochelle, W.J., Sakaguchi, K., Atabey, N., Cheon, H.G., Takagi, Y., Kinaia, T., Day, R.M., Miki, T., Burgess, W.H., Bottaro, D.P. Biochemistry (1999) [Pubmed]
  22. Targeting human prostatic carcinoma through basic fibroblast growth factor receptors in an animal model: characterizing and circumventing mechanisms of tumor resistance. Davol, P.A., Frackelton, A.R. Prostate (1999) [Pubmed]
  23. Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor. Reich-Slotky, R., Bonneh-Barkay, D., Shaoul, E., Bluma, B., Svahn, C.M., Ron, D. J. Biol. Chem. (1994) [Pubmed]
  24. Induction of urothelial cell proliferation by fibroblast growth factor-7 in RAG1-deficient mice. Bassuk, J.A., Cochrane, K., Mitchell, M.E. Adv. Exp. Med. Biol. (2003) [Pubmed]
  25. Analysis of growth factor and receptor mRNA levels during development of the rat seminal vesicle and prostate. Thomson, A.A., Foster, B.A., Cunha, G.R. Development (1997) [Pubmed]
  26. Ribosomal S6 kinase as a mediator of keratinocyte growth factor-induced activation of Akt in epithelial cells. Pan, Z.Z., Devaux, Y., Ray, P. Mol. Biol. Cell (2004) [Pubmed]
  27. Keratinocyte growth factor and acidic fibroblast growth factor are mitogens for primary cultures of mammary epithelium. Imagawa, W., Cunha, G.R., Young, P., Nandi, S. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  28. A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Botchkareva, N.V., Botchkarev, V.A., Chen, L.H., Lindner, G., Paus, R. Dev. Biol. (1999) [Pubmed]
  29. Pattern of expression of the KGF receptor and its ligands KGF and FGF-10 during postnatal mouse mammary gland development. Pedchenko, V.K., Imagawa, W. Mol. Reprod. Dev. (2000) [Pubmed]
  30. Keratinocyte growth factor decreases total parenteral nutrition-induced apoptosis in mouse intestinal epithelium via Bcl-2. Wildhaber, B.E., Yang, H., Teitelbaum, D.H. J. Pediatr. Surg. (2003) [Pubmed]
  31. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Bellusci, S., Furuta, Y., Rush, M.G., Henderson, R., Winnier, G., Hogan, B.L. Development (1997) [Pubmed]
  32. Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities. Reich-Slotky, R., Shaoul, E., Berman, B., Graziani, G., Ron, D. J. Biol. Chem. (1995) [Pubmed]
  33. Multiple structural elements determine ligand binding of fibroblast growth factor receptors. Evidence that both Ig domain 2 and 3 define receptor specificity. Zimmer, Y., Givol, D., Yayon, A. J. Biol. Chem. (1993) [Pubmed]
  34. Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Kettunen, P., Laurikkala, J., Itäranta, P., Vainio, S., Itoh, N., Thesleff, I. Dev. Dyn. (2000) [Pubmed]
  35. Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes. Dlugosz, A.A., Cheng, C., Denning, M.F., Dempsey, P.J., Coffey, R.J., Yuspa, S.H. Cell Growth Differ. (1994) [Pubmed]
  36. Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction. Rubin, J.S., Bottaro, D.P., Chedid, M., Miki, T., Ron, D., Cunha, G.R., Finch, P.W. EXS. (1995) [Pubmed]
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