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Gene Review

Fgf18  -  fibroblast growth factor 18

Mus musculus

Synonyms: D130055P09Rik, FGF-18, Fibroblast growth factor 18, zFGF5
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Disease relevance of Fgf18


High impact information on Fgf18


Biological context of Fgf18


Anatomical context of Fgf18


Regulatory relationships of Fgf18


Other interactions of Fgf18

  • Fgf17 is expressed later and broader than either Fgf8 or Fgf18 [14].
  • Here, we report the expression from early streak stage to midgestation of two newly-identified murine genes, Fgf17 and Fgf18, that are most closely related to Fgf8 (63.7% and 56.8% identical, respectively, at the amino acid level) [8].
  • TGF-beta also stimulated expression of FGF18 mRNA in the cultures and the effects of TGF-beta on metatarsal development were blocked or partially blocked by pretreatment with FGF signaling inhibitors [15].
  • All these effects of FGF-18 bore a close resemblance to those of FGF-2, whereas FGF-10 affects none of these cells [3].
  • This suggests that the regulation of FGF18 expression is a major function of GSK3 during endochondral bone development [13].

Analytical, diagnostic and therapeutic context of Fgf18

  • In this study we used a chick electroporation assay and in vitro mouse brain explant experiments to compare the activity of FGF17b and FGF18 to FGF8a and FGF8b [5].
  • The two tissues which appeared to be the primary targets of FGF-18 were the liver and small intestine, both of which exhibited histologic evidence of proliferation and showed significant gains in organ weight following 7 (sometimes 3) days of FGF-18 treatment [11].
  • This work, thus, identifies FGF18 and FGFR3 as potential molecular targets for intervention in tissue engineering aimed at cartilage repair and regeneration of damaged cartilage [16].
  • In further experiments, T(3) enhanced FGF2 and FGF18 activation of the MAPK-signaling pathway but inhibited their activation of signal transducer and activator of transcription-1 [17].
  • FGF4 and FGF18 are detected at highest levels by RT-PCR and microarrays [18].


  1. FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Liu, Z., Lavine, K.J., Hung, I.H., Ornitz, D.M. Dev. Biol. (2007) [Pubmed]
  2. Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. Ohbayashi, N., Hoshikawa, M., Kimura, S., Yamasaki, M., Fukui, S., Itoh, N. J. Biol. Chem. (1998) [Pubmed]
  3. Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10. Shimoaka, T., Ogasawara, T., Yonamine, A., Chikazu, D., Kawano, H., Nakamura, K., Itoh, N., Kawaguchi, H. J. Biol. Chem. (2002) [Pubmed]
  4. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Liu, Z., Xu, J., Colvin, J.S., Ornitz, D.M. Genes Dev. (2002) [Pubmed]
  5. FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Liu, A., Li, J.Y., Bromleigh, C., Lao, Z., Niswander, L.A., Joyner, A.L. Development (2003) [Pubmed]
  6. FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Ohbayashi, N., Shibayama, M., Kurotaki, Y., Imanishi, M., Fujimori, T., Itoh, N., Takada, S. Genes Dev. (2002) [Pubmed]
  7. Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  8. Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Maruoka, Y., Ohbayashi, N., Hoshikawa, M., Itoh, N., Hogan, B.L., Furuta, Y. Mech. Dev. (1998) [Pubmed]
  9. Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors. Ellsworth, J.L., Berry, J., Bukowski, T., Claus, J., Feldhaus, A., Holderman, S., Holdren, M.S., Lum, K.D., Moore, E.E., Raymond, F., Ren, H., Shea, P., Sprecher, C., Storey, H., Thompson, D.L., Waggie, K., Yao, L., Fernandes, R.J., Eyre, D.R., Hughes, S.D. Osteoarthr. Cartil. (2002) [Pubmed]
  10. Fgf18 is required for embryonic lung alveolar development. Usui, H., Shibayama, M., Ohbayashi, N., Konishi, M., Takada, S., Itoh, N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. Hu, M.C., Qiu, W.R., Wang, Y.P., Hill, D., Ring, B.D., Scully, S., Bolon, B., DeRose, M., Luethy, R., Simonet, W.S., Arakawa, T., Danilenko, D.M. Mol. Cell. Biol. (1998) [Pubmed]
  12. FGF18 represses noggin expression and is induced by calcineurin. Reinhold, M.I., Abe, M., Kapadia, R.M., Liao, Z., Naski, M.C. J. Biol. Chem. (2004) [Pubmed]
  13. Glycogen synthase kinase 3 controls endochondral bone development: contribution of fibroblast growth factor 18. Kapadia, R.M., Guntur, A.R., Reinhold, M.I., Naski, M.C. Dev. Biol. (2005) [Pubmed]
  14. Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Xu, J., Liu, Z., Ornitz, D.M. Development (2000) [Pubmed]
  15. Co-ordination of TGF-beta and FGF signaling pathways in bone organ cultures. Mukherjee, A., Dong, S.S., Clemens, T., Alvarez, J., Serra, R. Mech. Dev. (2005) [Pubmed]
  16. Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. Davidson, D., Blanc, A., Filion, D., Wang, H., Plut, P., Pfeffer, G., Buschmann, M.D., Henderson, J.E. J. Biol. Chem. (2005) [Pubmed]
  17. Thyroid hormones regulate fibroblast growth factor receptor signaling during chondrogenesis. Barnard, J.C., Williams, A.J., Rabier, B., Chassande, O., Samarut, J., Cheng, S.Y., Bassett, J.H., Williams, G.R. Endocrinology (2005) [Pubmed]
  18. FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells. Zhong, W., Wang, Q.T., Sun, T., Wang, F., Liu, J., Leach, R., Johnson, A., Puscheck, E.E., Rappolee, D.A. Mol. Reprod. Dev. (2006) [Pubmed]
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