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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The stain removal performance of a new anti-hypersensitivity dentifrice.

OBJECTIVE: To investigate the stain removal potential in vitro of a new anti-hypersensitivity dentifrice. The dentifrice contains a low level of abrasive, the zwitterionic surfactant cocamidopropyl betaine, and potassium nitrate. It has been developed to be as gentle as possible to tooth surfaces and oral soft tissues, while effectively treating dentinal hypersensitivity. METHODOLOGY: The Relative Dentine Abrasivity (RDA) method was used to measure abrasivity. The Pellicle Cleaning Ratio (PCR) and the Natural Extrinsic Stain Removal (NESR) methods were used to test stain removal performance against suitable controls. RESULTS: The RDA value for the formulation was 34 +/- 2 (Mean +/- S.E.). The PCR value was 46 +/- 4, comparable with Elmex Sensitive. The NESR test, which has previously been shown to give better clinical correlation than the PCR, demonstrated that the new formulation gave superior stain removal performance compared with both Sensodyne MultiCare and a conventional nonsensitivity formulation, and similar stain removal performance to Elmex Sensitive. CONCLUSION: The new formulation has been shown, in these studies, to combine low abrasivity with an in vitro stain removal performance comparable with that of benchmark marketed pastes.[1]


  1. The stain removal performance of a new anti-hypersensitivity dentifrice. Creeth, J.E., Price, K.S., Wicks, M.A. The Journal of clinical dentistry (2006) [Pubmed]
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