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Chemical Compound Review

CHEMBL1644029     potassium nitrate

Synonyms: CHEBI:1158777, E252
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Disease relevance of potassium nitrate


High impact information on potassium nitrate


Chemical compound and disease context of potassium nitrate


Biological context of potassium nitrate


Anatomical context of potassium nitrate


Associations of potassium nitrate with other chemical compounds

  • To demonstrate the utility of the method, we measured over the course of 18 days, the total area of neovascularization in rabbit corneas cauterized with silver/potassium nitrate, and treated topically with either normal saline (control) or 1% prednisolone acetate (100 microliters four times daily for 10 days) [23].
  • The cyano content in the sample is distilled as hydrocyanic acid, trapped in 0.1 M potassium nitrate at pH 12-13, and determined by means of the cyanide ion-selective electrode [24].
  • A total of 405 lactic acid bacteria (LAB) isolated from spoiled, vacuum-packaged, salted, sodium nitrite- or potassium nitrate-treated, cold-smoked rainbow trout stored at 4 degrees C or 8 degrees C were characterised and identified using a molecular method [25].
  • Nitrates added in the form of a 1 M potassium nitrate solution were observed to completely disappear in conjunction with significant recovery of pH and alkalinity (i.e. biological denitrification) [26].
  • The purpose of this study was to evaluate the effectiveness of a patient-applied 10% potassium nitrate glycerine-based gel in decreasing dentinal sensitivity on cold on teeth with exposed dentin apical to the cemento-enamel junction, 12 patients, each having 3 hypersensitive teeth, were tested [27].

Gene context of potassium nitrate

  • Using potassium nitrate as N source in mixtures of 0.04 g N/g substrate (0.04% wt./vol.) at pH 4.5, it was found that incubation periods of 3, 4, and 5 days were optimal for protein production on cellulose and holocellulose fractions, and whole straw, respectively [28].

Analytical, diagnostic and therapeutic context of potassium nitrate

  • The subjects were divided into 2 groups, with 18 being given a 5% potassium nitrate dentifrice (treated group) and the other 18 a vehicle paste (control group) [29].
  • The effectiveness of a 5% potassium nitrate dentifrice as a daily home treatment for dentinal hypersensitivity was evaluated in a double-blind study in 36 Japanese subjects who complained of cold and/or tactile hypersensitivity [29].
  • Four studies were included in the meta-analysis which showed statistically significant effect of potassium nitrate toothpaste on air blast and tactile sensitivity, e.g. the meta analysis of air blast sensitivity showed a standardized mean difference in sensitivity score of -1.51 (95% CI: -2.09 to -0.94) in favour of treatment [30].
  • The results of this serological test were very satisfactory with respect to accuracy and rapidity, particularly when performed in combination with concomitant physiological tests only for assimilation of inositol and potassium nitrate [31].
  • In this study, a 4% potassium nitrate-zinc oxide eugenol temporary cement was used to secure provisional crowns over recently prepared teeth and it significantly reduced the incidence and severity of pain after tooth preparation and impression taking [32].


  1. Quantitation of corneal neovascularization using computerized image analysis. Proia, A.D., Chandler, D.B., Haynes, W.L., Smith, C.F., Suvarnamani, C., Erkel, F.H., Klintworth, G.K. Lab. Invest. (1988) [Pubmed]
  2. Clinical evaluation of a new treatment for dentinal hypersensitivity. Tarbet, W.J., Silverman, G., Stolman, J.M., Fratarcangelo, P.A. J. Periodontol. (1980) [Pubmed]
  3. Treatment of nitrate intoxication in a cow. Van Dijk, S., Lobsteyn, A.J., Wensing, T., Breukink, H.J. Vet. Rec. (1983) [Pubmed]
  4. Sodium nitrite and potassium nitrate in control of nonproteolytic Clostridium botulinum outgrowth and toxigenesis in vacuum-packed cold-smoked rainbow trout. Hyytiä, E., Eerola, S., Hielm, S., Korkeala, H. Int. J. Food Microbiol. (1997) [Pubmed]
  5. Potassium nitrate: an effective treatment for pulpitis. Hodosh, M., Hodosh, S.H., Shklar, G., Hodosh, A.J. Oral Surg. Oral Med. Oral Pathol. (1983) [Pubmed]
  6. Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans. McKnight, G.M., Smith, L.M., Drummond, R.S., Duncan, C.W., Golden, M., Benjamin, N. Gut (1997) [Pubmed]
  7. Silver nitrate cauterization: characterization of a new model of corneal inflammation and hyperalgesia in rat. Wenk, H.N., Honda, C.N. Pain (2003) [Pubmed]
  8. Potassium-specific effects of levosimendan on heart mitochondria. Kopustinskiene, D.M., Pollesello, P., Saris, N.E. Biochem. Pharmacol. (2004) [Pubmed]
  9. Role of the Bradyrhizobium japonicum ntrC gene product in differential regulation of the glutamine synthetase II gene (glnII). Martin, G.B., Chapman, K.A., Chelm, B.K. J. Bacteriol. (1988) [Pubmed]
  10. Nitrate improves growth in salt-stressed citrus seedlings through effects on photosynthetic activity and chloride accumulation. Iglesias, D.J., Levy, Y., Gómez-Cadenas, A., Tadeo, F.R., Primo-Millo, E., Talon, M. Tree Physiol. (2004) [Pubmed]
  11. The efficacy of three desensitizing agents in treatment of dentine hypersensitivity. Pamir, T., Ozyazici, M., Baloğlu, E., Onal, B. Journal of clinical pharmacy and therapeutics. (2005) [Pubmed]
  12. Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastes. West, N.X., Addy, M., Jackson, R.J., Ridge, D.B. Journal of clinical periodontology. (1997) [Pubmed]
  13. Efficacy of a dentifrice containing 5% potassium nitrate and 1500 PPM sodium monofluorophosphate in a precipitated calcium carbonate base on dentinal hypersensitivity. Schiff, T., Dos Santos, M., Laffi, S., Yoshioka, M., Baines, E., Brasil, K.D., McCool, J.J., De Vizio, W. The Journal of clinical dentistry. (1998) [Pubmed]
  14. Comparative efficacy of two dentifrices containing 5% potassium nitrate on dentinal sensitivity: a twelve-week clinical study. Ayad, F., Berta, R., De Vizio, W., McCool, J., Petrone, M.E., Volpe, A.R. The Journal of clinical dentistry. (1994) [Pubmed]
  15. Effectiveness of desensitizing agents. Kishore, A., Mehrotra, K.K., Saimbi, C.S. Journal of endodontics. (2002) [Pubmed]
  16. The effect of exercise associated with acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats. Grudziński, I., Szymański, A., Chomiczewski, K. Arch. Environ. Contam. Toxicol. (1991) [Pubmed]
  17. Studies on the muscle-paralyzing components of the juice of the banana plant. Singh, Y.N., Inman, W.D., Johnson, A., Linnell, E.J. Archives internationales de pharmacodynamie et de thérapie. (1993) [Pubmed]
  18. Dimorphism of Scopulariopsis brevicaulis: morphogenesis of the mould to yeast phase. Paula, C.R., Purchio, A., Gambale, W., Corrêa, B. Mycopathologia (1987) [Pubmed]
  19. Reduction of oxidized cytochrome c by ascorbate ion. Williams, N.H., Yandell, J.K. Biochim. Biophys. Acta (1985) [Pubmed]
  20. Physiological characters of Sporothrix schenckii isolates. Ghosh, A., Maity, P.K., Hemashettar, B.M., Sharma, V.K., Chakrabarti, A. Mycoses (2002) [Pubmed]
  21. Efficacy of a potassium nitrate mouthwash in alleviating cervical dentine sensitivity (CDS). Gillam, D.G., Bulman, J.S., Jackson, R.J., Newman, H.N. Journal of clinical periodontology. (1996) [Pubmed]
  22. Clinical dentin hypersensitivity: understanding the causes and prescribing a treatment. Jacobsen, P.L., Bruce, G. The journal of contemporary dental practice [electronic resource]. (2001) [Pubmed]
  23. In vivo measurement of corneal angiogenesis with video data acquisition and computerized image analysis. Conrad, T.J., Chandler, D.B., Corless, J.M., Klintworth, G.K. Lab. Invest. (1994) [Pubmed]
  24. Determination of cyanocobalamin by thermal decomposition of the cyano group using an ion-selective electrode. Goldstein, S., Duca, A. Journal of pharmaceutical sciences. (1976) [Pubmed]
  25. Characterisation of lactic acid bacteria from spoiled, vacuum-packaged, cold-smoked rainbow trout using ribotyping. Lyhs, U., Björkroth, J., Korkeala, H. Int. J. Food Microbiol. (1999) [Pubmed]
  26. Use of volatile fatty acids from an acid-phase digester for denitrification. Elefsiniotis, P., Wareham, D.G., Smith, M.O. J. Biotechnol. (2004) [Pubmed]
  27. The effectiveness of a patient-applied tooth desensitizing gel. A pilot study. Reinhart, T.C., Killoy, W.J., Love, J., Overman, P.R., Sakumura, J.S. Journal of clinical periodontology. (1990) [Pubmed]
  28. Bioconversion of wheat straw and wheat straw components into single-cell protein. Chahal, D.S., Moo-Young, M., Dhillon, G.S. Can. J. Microbiol. (1979) [Pubmed]
  29. Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. Nagata, T., Ishida, H., Shinohara, H., Nishikawa, S., Kasahara, S., Wakano, Y., Daigen, S., Troullos, E.S. Journal of clinical periodontology. (1994) [Pubmed]
  30. Potassium nitrate toothpaste for dentine hypersensitivity. Poulsen, S., Errboe, M., Hovgaard, O., Worthington, H.W. Cochrane database of systematic reviews (Online) (2001) [Pubmed]
  31. Rapid identification of yeasts by serological methods: a combined serological and biological method. Taguchi, M., Tsukiji, M., Tsuchiya, T. Sabouraudia. (1979) [Pubmed]
  32. Potassium nitrate-zinc oxide eugenol temporary cement for provisional crowns to diminish postpreparation tooth pain. Hodosh, A.J., Hodosh, S., Hodosh, M. The Journal of prosthetic dentistry. (1993) [Pubmed]
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