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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Auraptene Decreases the Activity of Matrix Metalloproteinases in Dextran Sulfate Sodium- Induced Ulcerative Colitis in ICR Mice.

Previously we reported that auraptene was a potent suppressant for matrix metalloproteinase (MMP)-7 expression in HT-29 human colon cancer cells. In the present study, we examined the effects of auraptene on MMP-2, -7, and -9 expression in colonic mucosa from dextran sulfate sodium (DSS)-induced ulcerative colitis mice. Auraptene remarkably suppressed the DSS-induced gelatinolytic activity of MMP-7 as well as the expression of MMP-2 and -9, suggesting that it might be useful in anti-metastatic therapies via the targeting of MMPs.[1]

References

  1. Auraptene Decreases the Activity of Matrix Metalloproteinases in Dextran Sulfate Sodium-Induced Ulcerative Colitis in ICR Mice. Kawabata, K., Murakami, A., Ohigashi, H. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
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